EGFR/ERBB1/HER1_AntibodySystem

The epidermal growth factor receptor (EGFR, HER-1, c-erbB-1) is one of the four transmembrane growth factor receptor proteins that share similarities in structure and function. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).