Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: Mammalian Cells
Accession: P06731
Protein length: Met1-Ala685
Host species: Mouse
Isotype: IgG2a
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Host species: Humanized
Isotype: IgG1-Kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Host species: Humanized
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Host species: Humanized
Isotype: IgG1-kappa/lambdawithdomaincrossover
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Host species: Chimeric
Isotype: IgG1-Kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
CEACAM5, also known as CEA or D66e, belongs to the large CEACAM subfamily of the immunoglobulin superfamily. CEACAM5 is a member of the carcinoembryonic antigen (CEA) family of 12 glycoproteins, not to be confused with the serum CEA tumor marker for colorectal cancer prognosis that was identified years ago. CEACAM5 cell-surface glycoproteins may play a potential role in tumor progression, metastasis, and cell adhesion-inhibiting differentiation and apoptosis while disrupting tissue architecture. CEACAM5 has been shown to have higher expression in NSQ NSCLC and lower expression in healthy lung tissue. High differential expression may ultimately allow CEACAM5 to become a potential target in NSCLC.
