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Synthesis of an RBM39 Degrader That Downregulates CEP192 and Induces Disorganized Spindle Structures

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Nat Commun. 2025 Mar 2

Targeting the ceramidase ACER3 attenuates cholestasis in mice by mitigating bile acid overload via unsaturated ceramide-mediated LXRβ signaling transduction

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Adv Sci (Weinh). 2025 Feb 25

Reprogramming the Tumor Immune Microenvironment with ICAM-1-Targeted Antibody‒Drug Conjugates and B7-H3-CD3 Bispecific Antibodies

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The regulatory role of the Netrin-1/UNC5H3 pathway in neuronal pyroptosis after stroke

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J. Med. Chem. 2025,January 2

TarIKGC: A Target Identification Tool Using Semantics-Enhanced Knowledge Graph Completion with Application to CDK2 Inhibitor Discovery

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NPJ Vaccines . 2025

A KIF20A-based thermosensitive hydrogel vaccine effectively potentiates immune checkpoint blockade herapy for hepatocellular carcinoma

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Enhanced Immunogenicity and Affinity with A35R-Fc-Based Chimeric Protein Compared to MPXV A35R Protein

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The cryo-EM structure of homotetrameric attachment glycoprotein from langya henipavirus

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Improving combination cancer immunotherapy by manipulating dual immunomodulatory signals with enzyme-triggered, cell-penetrating peptide-mediated biomodulators

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