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Research Spotlight

30
2026-09

ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer

ZFP36L2 couples stress sensing with phenotypic plasticity via RNA-dependent biomolecular condensates, driving dedifferentiation into LGR5+ stem cell states during intestinal regeneration and CRC metastasis.

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22
2026-09

Synthetic transcription factors designed by domain recombination enhance CAR T cell antitumor function

DESynR: domain recombination generates synthetic AP-1, ETS and FOX transcription factors that reprogram CAR T cells into non-natural states, enhancing persistence, cytotoxicity and antitumor function.

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14
2026-09

A serpin–myeloid axis in pancreatic cancer heterogeneity and immune evasion

Cancer-derived SERPINE1 and SERPINB2 organize fibrin-rich niches that retain immunosuppressive macrophages and exclude CD8+ T cells in PDAC, driving immunotherapy resistance.

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07
2026-09

Tabula Sapiens 2.0: A comprehensive transcriptomic atlas of human cell types

Tabula Sapiens 2.0: 1.1M single-cell transcriptomes across 28 human tissues, revealing transcription factor specificity and heterogeneous senescence programs.

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02
2026-09

Neurodegeneration as a dysregulation of neuroimmune crosstalk

Cell perspective on neurodegeneration as neuroimmune crosstalk failure. Microglia–T cell interactions, immune checkpoints, and therapeutic strategies for AD, PD, ALS.

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24
2026-08

Shared principles of human and bacterial antiviral immunity

Nature review on shared antiviral immunity across kingdoms: cGAS-STING, inflammasomes, viperin, CRISPR and interferon-stimulated genes in human and bacterial defence.

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17
2026-08

MIF mediates monocyte-dependent inhibition of natural killer cell cytotoxicity in triple-negative breast cancer

Monocyte-derived MIF suppresses NK cell cytotoxicity via CXCR4 in TNBC. MIF inhibition restores NK cell killing and reduces metastasis, highlighting a therapeutic target.

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10
2026-08

Antigen presentation by CD40+MHC-II+ astrocytes promotes CNS autoimmunity

CD40+MHC-II+ astrocytes present antigen to CD4+ T cells via CD40L, inducing lipid droplets and NF-κB acetylation to drive CNS autoimmunity in EAE and MS.

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03
2026-08

Spatial atlas of the human brain vasculature reveals specialized cell ensembles

Spatial atlas of 1.5M human cerebrovascular cells reveals specialized endothelial, mural, fibroblast and macrophage ensembles along arteriovenous axis, linking vascular organization to neurological disease susceptibility.

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27
2026-07

CD98hc-targeted antibody shuttles for central nervous system delivery with broad cross-species reactivity

Active learning generates anti-CD98hc antibodies with broad mouse, cyno, human cross-reactivity for efficient brain delivery, eliminating need for transgenic models.

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