T-cell surface glycoprotein CD3 epsilon chain, also known as CD3E, is a single-pass type I membrane protein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
Host species: Humanized
Isotype: IgG1-Kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: Mammalian Cells
Accession: P07766
Protein length: Met1-Asp126
Host species: Humanized
Isotype: Ig(G4-kappa_G4-lambda)
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Host species: Humanized
Isotype: IgG1-kappa/scFv-h-CH2-CH3
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Host species: Chimeric
Isotype: IgG4-lambda
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Host species: Chimeric
Isotype: IgG1-kappa/scFv-h-CH2-CH3
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Host species: Humanized
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Host species: Humanized
Isotype: IgG1-kappa-lambda
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Host species: Humanized
Isotype: scFv-TCR
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Host species: Human
Isotype: IgG1-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
