Polyethylene glycol (PEG) is a polymer which is widely used for covalent modification of biological polymers such as proteins and peptides.

PEG modification can change the physical and chemical properties of drugs, including conformation, electrostatic binding, hydrophobicity, etc. These physical and chemical changes increase the retention time of drugs in vivo, improve the plasma half-life, prolong absorption time, affect the binding affinity of drugs with cell receptors, and improve tumor targeting. PEG modification can reduce dosing times, improve efficacy, improve tolerability, and reduce severity and adverse events. Meanwhile, PEG can increase the solubility and stability of protein, and also facilitate the production and storage of drugs.

PEG is often used in drug delivery and drug modification technologies, which can be directly coupled to the drug, or attached to the drug surface and encapsulated in nanomaterials.

PEG modification of the main structure

PEG modification can be used to modify proteins, peptides, oligonucleotides, antibody fragments, organic small molecules and nanoparticles, etc. A full understanding of the pharmacokinetic characteristics and biological analysis of PEG and PEG drugs is of great significance to evaluate their overall safety and promote the development of related technology.

PEG antibody is a very important tool in the research of PEG-modified drugs.

1. PEG antibodies can be used to detect peg-modified drugs.

2. PEG antibodies play an important role in PK research of PEGylated drugs.

3. PEG antibodies can also be used for immunogenicity analysis of PEG modified drugs. Since PEG modification may lead to the formation of new epitopes, resulting in new immunogenicity and immune responses, among these anti-drug antibodies, anti-PEG IgG and IgM have been shown to cause accelerated drug blood clearance (ABC phenomenon) and severe or even fatal allergic reactions (HSRs). Therefore, correct detection of anti-PEG antibodies may predict adverse reactions of PEG modified drugs, thus improving the safety and efficacy.