Cervical cancer ranks as the fourth most common cancer among women globally and is caused by persistent infection with the Human Papillomavirus (HPV), a small DNA virus known to infect the skin, genital areas, and throat. Based on disease severity, HPV is categorized into low-risk and high-risk types. Persistent infection with high-risk HPV, particularly types 16 and 18, is responsible for 70% of cervical cancer cases due to their potential to cause malignant tumors.

Glycosylation is a common post-translational modification in eukaryotic cells that plays a crucial role in protein folding, stability, activity, and intercellular signaling.

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The recent surge in bispecific antibodies

Eastern equine encephalitis virus

Apoptosis is a form of programmed cell death, specifically a regulated cell death process, characterized primarily by nuclear pyknosis, cell shrinkage, membrane blebbing, and DNA fragmentation. Furthermore, caspase family proteases and other key apoptotic regulators play pivotal roles in apoptosis research. Three principal pathways mediate apoptosis: the intrinsic apoptotic pathway, the extrinsic apoptotic pathway, and the endoplasmic reticulum (ER) stress-induced apoptotic pathway.

Intervertebral disc degeneration (IVDD), a prevalent degenerative spinal disorder, is the leading cause of low back pain. Its incidence rises sharply with population aging, imposing not only severe pain, reduced quality of life, and disability on patients, but also an enormous economic burden on healthcare systems. The core pathological mechanisms include mechanical overload–induced annulus fibrosus (AF) rupture triggering nucleus pulposus (NP) herniation and nerve compression, as well as intradiscal oxidative stress (ROS) accumulation driving cell apoptosis, senescence, inflammation, and extracellular matrix (ECM) metabolic imbalance. Current conservative or surgical treatments are limited by high recurrence rates and lack targeted AF repair. The avascular nature of the disc restricts drug delivery, and repeated local injections may even accelerate degeneration. Therefore, developing a strategy that simultaneously targets oxidative stress and ECM imbalance is urgently needed.

July 23, 2025 — Diego V. Bohórquez’s team at Duke University published a landmark study in Nature titled "A gut sense for a microbial pattern regulates feeding," revealing for the first time a neural mechanism for rapid microbial sensing in the gut. Termed "neurobiotic sense," this system enables the brain to receive real-time chemical signals from gut microbiota, acting like a "sixth sense" to regulate feeding behavior.

Weak bands, high background, inconsistent results... Who understands the pain of Phosphorylated Proteins Western Blot (WB)? The "nightmare" status of phosphorylated proteins WB stems from its inherent low abundance, high dynamism, and susceptibility to degradation. Minor operational deviations can cause signal loss or nonspecific amplification. Today, Dr. Connie analyzes these difficulties and shares actionable solutions.

Every researcher dreads two scenarios: being unable to find reliable protocols, or meticulously following steps only to get irreproducible results! Worry no more. These extensively tested protocol repositories cover everything from fundamental techniques to cutting-edge methods – offering free access, downloadable PDFs, and video tutorials. Your PI or lab mates might not have told you about these.

RRID stands for Research Resource Identifier. It is a persistent and unique identifier for research resources, designed to standardize their citation in scientific literature. RRIDs facilitate the identification and tracking of resources, enhancing research transparency, reproducibility, and resource traceability.

Mycoplasma pneumoniae (MP), one of the smallest free-living microorganisms known, occupies an evolutionary niche between bacteria and viruses. This single-celled organism measures 0.2–0.3 μm in diameter and 0.5–1.0 μm in length. Lacking a cell wall, it exhibits intrinsic resistance to penicillin and cephalosporin antibiotics. Its pleomorphic morphology varies with environmental conditions and growth stages. The MP cell comprises a plasma membrane, ribosomes, and double-stranded DNA, but lacks a nucleus, cell wall, flagella, or spores.

In June 2025, AntibodySystem products continued to drive global scientific advancement as research enabled by our high-specificity antibodies and recombinant proteins appeared in leading journals including Advanced Functional Materials, Cancer Research, and Chemical Engineering Journal. These publications represent breakthroughs across five critical domains: extracellular matrix regulation uncovering mechanical signaling in oral development; monkeypox virus immunoescape mechanisms; synthetic lethality approaches for targeted tumor therapy; antioxidant hydrogel-based repair of degenerative disc conditions; and nanotechnology-enhanced precision diagnostics for cardiovascular risk stratification. In each case—from fundamental mechanistic insights to advanced therapeutic and diagnostic platforms—AntibodySystem's core technologies delivered essential detection capabilities underpinning pivotal discoveries. Going forward, we remain dedicated to advancing scientific frontiers thcutting

AntibodySystem as a global leader in protein and antibody research, development, and manufacturing, today announced the official launch and operation of its dedicated Korean website: http://antibodysystem.co.kr. This strategic move marks a significant step in AntibodySystem's efforts to enhance its service for the South Korean market and elevate the experience for local customers.

Exercise is known to delay aging and improve metabolism, but what's the molecular mechanism behind it?

Fructose is ubiquitous in modern diets—from fruits and sweetened beverages to candies and baked goods. However, emerging research reveals a critical concern: excessive fructose consumption during early life may severely disrupt brain development. On June 11, 2025, a team led by Justin S.A. Perry at Memorial Sloan Kettering Cancer Center (MSKCC) published a landmark study in Nature titled "Early life high fructose exposure disrupts microglia function and impedes neurodevelopment". Their findings sound a critical alarm: Exposure to high-fructose environments during pivotal developmental windows (pregnancy and the neonatal period) directly impairs microglia—the brain’s essential "custodian" cells—through a GLUT5-dependent mechanism. This disrupts synaptic pruning and neuronal clearance, compromises neurodevelopment, and significantly elevates lifelong risks of cognitive deficits and anxiety-like behaviors.

A Listeria outbreak initially surfaced in early 2025 across 21 U.S. states, resulting in 38 infections and 12 deaths. The investigation revealed the earliest cases actually date back to 2018, with more than half of all infections occurring in 2024 and 2025. Listeria infections in the U.S. typically peak during the summer months.