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The recent surge in bispecific antibodies

Eastern equine encephalitis virus

Marburg virus (MARV), also known as Lake Victoria

The generation of the VBASE2 database was previously described (Retter et al. 2005).

Antibodies are immune system-related proteins called immunoglobulins. Each antibody consists of four polypeptide – two heavy chains and two light chains joined to form a "Y" shaped molecule.

The Kabat numbering scheme is a widely adopted standard for numbering the residues in an antibody in a consistent manner. However the scheme has problems!

The World Health Organization (WHO) has raised concerns about the emergence of Clade 1b in the Democratic Republic of Congo, which is spreading, especially among children. Though Clade 1b is not causing more severe disease, unequal vaccine distribution remains an issue. Understanding MPXV’s structure is key for improving vaccines and global health efforts.Key structural proteins of the Monkeypox virus (MPXV) are crucial for its transmission, host interaction, and immune evasion. A35R aids in transmission and is a vaccine target, while E8L, M1R, and A29L are essential for virus attachment, entry, and assembly. B6R is important for diagnostics, and D14L and H3L help the virus evade the immune system.

A study published in Science Translational Medicine  explores the development and efficacy of two potent neutralizing antibodies targeting the fusion glycoprotein (F protein) of Nipah virus (NiV). This research, conducted by Mapp Biopharmaceuticals in collaboration with multiple research institutions, aims to develop more effective antibody-based therapies against this deadly pathogen.

Recent research published in Nature reveals