Catalog No.
EHJ04001
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Thr461
Predicted molecular weight
50.34 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q5ZPR3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD276, B7-H3, Costimulatory molecule, B7H3, 4Ig-B7-H3, B7 homolog 3, CD276 antigen
Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature. PMID: 28399408
Molecular Pathways: Targeting B7-H3 (CD276) for Human Cancer Immunotherapy. PMID: 27208063
CD276 Promotes Vasculogenic Mimicry Formation in Hepatocellular Carcinoma via the PI3K/AKT/MMPs Pathway. PMID: 33204103
CD276-Positive Circulating Endothelial Cells Do Not Predict Response to Systemic Therapy in Advanced Colorectal Cancer. PMID: 31948091
The Role of CD276 in Cancers. PMID: 33842369
Prognostic Significance of CD276 in Non-small Cell Lung Cancer. PMID: 31737785
CD276 (B7-H3) Maintains Proliferation and Regulates Differentiation in Angiogenic Function in Late Endothelial Progenitor Cells. PMID: 30379377
Silencing of CD276 suppresses lung cancer progression by regulating integrin signaling. PMID: 32642118
Clinicopathological and Prognostic Characteristics of CD276 (B7-H3) Expression in Adrenocortical Carcinoma. PMID: 31998416
B7-H3, a checkpoint molecule, as a target for cancer immunotherapy. PMID: 32398947
B7-H3 in Cancer - Beyond Immune Regulation. PMID: 29860983
B7-H3/CD276: An Emerging Cancer Immunotherapy. PMID: 34349762
B7-H3 role in the immune landscape of cancer. PMID: 28695059
The MDM2 ligand Nutlin-3 differentially alters expression of the immune blockade receptors PD-L1 and CD276. PMID: 32874188
PBK phosphorylates MSL1 to elicit epigenetic modulation of CD276 in nasopharyngeal carcinoma. PMID: 33431797
[Next generation of anti-immune checkpoints antibodies]. PMID: 31903901
Cellular-Based Selections Aid Yeast-Display Discovery of Genuine Cell-Binding Ligands: Targeting Oncology Vascular Biomarker CD276. PMID: 30620189
Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells. PMID: 30753824
CD276 suppresses CAR-T cell function by promoting tumor cell glycolysis in esophageal squamous cell carcinoma. PMID: 33708423
CD276 and the gene signature composed of GATA3 and LGALS3 enable prognosis prediction of glioblastoma multiforme. PMID: 31075138
Prognostic value of immune checkpoint molecules in breast cancer. PMID: 32602545
Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors. PMID: 32341579
CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors. PMID: 30655315
The third group of the B7-CD28 immune checkpoint family: HHLA2, TMIGD2, B7x, and B7-H3. PMID: 28258693
A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276. PMID: 31044564
B7H3 ameliorates LPS-induced acute lung injury via attenuation of neutrophil migration and infiltration. PMID: 27515382
CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance. PMID: 33945793
Tumor B7-H3 (CD276) Expression and Survival in Pancreatic Cancer. PMID: 29996538
Endothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells. PMID: 24892449
Potential Therapeutic Targets of B7 Family in Colorectal Cancer. PMID: 32477326
Expression and Clinical Significance of Immune Checkpoint Regulator B7-H3 (CD276) in Human Meningioma. PMID: 31629137
MiR-1253 exerts tumor-suppressive effects in medulloblastoma via inhibition of CDK6 and CD276 (B7-H3). PMID: 32145124
Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors. PMID: 32685008
Targeting CD276 by CAR-T cells induces regression of esophagus squamous cell carcinoma in xenograft mouse models. PMID: 34052626
B7H3 As a Promoter of Metastasis and Promising Therapeutic Target. PMID: 30035102
Ultrasound molecular imaging in a human CD276 expression-modulated murine ovarian cancer model. PMID: 24389327
Expression patterns of the immune checkpoint ligand CD276 in urothelial carcinoma. PMID: 33845814
Temozolomide promotes immune escape of GBM cells via upregulating PD-L1. PMID: 31285949
CD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1. PMID: 34290311
B7-H3-redirected chimeric antigen receptor T cells target glioblastoma and neurospheres. PMID: 31466914
A regulatory loop among CD276, miR-29c-3p, and Myc exists in cancer cells against natural killer cell cytotoxicity. PMID: 33798549
Preclinical Development of MGC018, a Duocarmycin-based Antibody-drug Conjugate Targeting B7-H3 for Solid Cancer. PMID: 32967924
Olive flounder CD276 (B7-H3) a coinhibitory molecule for T cells: Responses during viral hemorrhagic septicemia virus (VHSV) stimulation. PMID: 29253650
Prognostic impact of tumor-infiltrating CD276/Foxp3-positive lymphocytes and associated circulating cytokines in patients undergoing radical nephrectomy for localized renal cell carcinoma. PMID: 30930997
Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function. PMID: 28685773
B7-H3 promotes colorectal cancer angiogenesis through activating the NF-κB pathway to induce VEGFA expression. PMID: 31974361
Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy. PMID: 31611650
Enhancing Anti-PD-1/PD-L1 Immune Checkpoint Inhibitory Cancer Therapy by CD276-Targeted Photodynamic Ablation of Tumor Cells and Tumor Vasculature. PMID: 30452269
For research use only. Not for human or drug use.
