Catalog No.
YHG17601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln19-Pro139
Predicted molecular weight
16.03 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q08722
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Leukocyte surface antigen CD47, CD47, Antigenic surface determinant protein OA3, IAP, Integrin-associated protein, Protein MER6, MER6
Aging-associated changes in CD47 arrangement and interaction with thrombospondin-1 on red blood cells visualized by super-resolution imaging. PMID: 32866348
The expression of CD47 and its association with 2,3-DPG levels in stored leuco-reduced blood units. PMID: 30713045
Clinicopathological analysis of immunohistochemical expression of CD47 and SIRPalpha in adult T-cell leukemia/lymphoma. PMID: 32569413
SIRPalpha/CD47 axis controls the maintenance of transplant tolerance sustained by myeloid-derived suppressor cells. PMID: 31207067
Targeting CD47/TNFAIP8 by miR-155 overcomes drug resistance and inhibits tumor growth through induction of phagocytosis and apoptosis in multiple myeloma. PMID: 33256380
CD47 on artificial structures. PMID: 26298418
CD47 blockade alleviates acute rejection of allogeneic mouse liver transplantation by reducing ischemia/reperfusion injury. PMID: 31884341
Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47. PMID: 23101472
Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells. PMID: 32929084
Just eat it: A review of CD47 and SIRP-alpha antagonism. PMID: 32517874
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. PMID: 22451913
Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer. PMID: 31771616
CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development. PMID: 30308165
Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo. PMID: 31676794
CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. PMID: 19632179
Upregulation of CD47 Is a Host Checkpoint Response to Pathogen Recognition. PMID: 32576678
Exosome-SIRPalpha, a CD47 blockade increases cancer cell phagocytosis. PMID: 28086180
The interaction between signal regulatory protein alpha (SIRPalpha) and CD47: structure, function, and therapeutic target. PMID: 24215318
The overall potential of CD47 in cancer immunotherapy: with a focus on gastrointestinal tumors. PMID: 31686549
Engineering macrophages to phagocytose cancer cells by blocking the CD47/SIRP axis. PMID: 31183992
CD47 Promotes Tumor Invasion and Metastasis in Non-small Cell Lung Cancer. PMID: 27411490
CD47 expression in gastric cancer clinical correlates and association with macrophage infiltration. PMID: 33389016
The CD47-SIRPalpha pathway in cancer immune evasion and potential therapeutic implications. PMID: 22310103
CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis. PMID: 31689243
Tumor-selective blockade of CD47 signaling with a CD47/PD-L1 bispecific antibody for enhanced anti-tumor activity and limited toxicity. PMID: 32761423
Functions and molecular mechanisms of the CD47-SIRPalpha signalling pathway. PMID: 19144521
Thrombospondin-1/CD47 Interaction Regulates Th17 and Treg Differentiation in Psoriasis. PMID: 31214201
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells. PMID: 26512116
Monoclonal anti-CD47 interference in red cell and platelet testing. PMID: 30516833
Tumor Microenvironment-Activatable Prodrug Vesicles for Nanoenabled Cancer Chemoimmunotherapy Combining Immunogenic Cell Death Induction and CD47 Blockade. PMID: 30762908
Chemotherapy induces enrichment of CD47(+)/CD73(+)/PDL1(+) immune evasive triple-negative breast cancer cells. PMID: 29367423
Targeted inhibition of CD47-SIRPalpha requires Fc-FcgammaR interactions to maximize activity in T-cell lymphomas. PMID: 31383641
CD47-signal regulatory protein alpha signaling system and its application to cancer immunotherapy. PMID: 29873856
Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPalpha Interaction as a Potential Cancer Immunotherapy. PMID: 32640189
A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer. PMID: 28378740
CD40 Enhances Type I Interferon Responses Downstream of CD47 Blockade, Bridging Innate and Adaptive Immunity. PMID: 31852716
TTI-621 (SIRPalphaFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding. PMID: 27856600
Simultaneous blocking of CD47 and PD-L1 increases innate and adaptive cancer immune responses and cytokine release. PMID: 30878596
Durable antitumor responses to CD47 blockade require adaptive immune stimulation. PMID: 27091975
Phagocytosis checkpoints as new targets for cancer immunotherapy. PMID: 31462760
CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. PMID: 19632178
Blockade of CD47 or SIRPalpha: a new cancer immunotherapy. PMID: 32799682
Targeting the CD47-SIRPalpha signaling axis: current studies on B-cell lymphoma immunotherapy. PMID: 30226089
Recent Advancements in CD47 Signal Transduction Pathways Involved in Vascular Diseases. PMID: 32733941
CD47 is a novel potent immunotherapy target in human malignancies: current studies and future promises. PMID: 29667847
Dysregulated integrin alphaVbeta3 and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis. PMID: 31534047
Targeting CD47 in Sezary syndrome with SIRPalphaFc. PMID: 30962222
Is CD47 a potentially promising therapeutic target in cardiovascular diseases? - Role of CD47 in cardiovascular diseases. PMID: 32061866
CD47: a potential immunotherapy target for eliminating cancer cells. PMID: 26830085
CD47 regulates renal tubular epithelial cell self-renewal and proliferation following renal ischemia reperfusion. PMID: 27259369
miR-128 Regulates Tumor Cell CD47 Expression and Promotes Anti-tumor Immunity in Pancreatic Cancer. PMID: 32536914
Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies. PMID: 28234345
Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPalpha-CD47 axis. PMID: 31089204
CD47 does not mediate amyloid-beta(1-42) protofibril-stimulated microglial cytokine release. PMID: 25451248
Co-engaging CD47 and CD19 with a bispecific antibody abrogates B-cell receptor/CD19 association leading to impaired B-cell proliferation. PMID: 30569825
Targeting CD47 and Autophagy Elicited Enhanced Antitumor Effects in Non-Small Cell Lung Cancer. PMID: 28351890
Donor CD47 controls T cell alloresponses and is required for tolerance induction following hepatocyte allotransplantation. PMID: 27230788
CD47 signaling regulates the immunosuppressive activity of VEGF in T cells. PMID: 25200950
Role of Erythrocyte CD47 in Intracerebral Hematoma Clearance. PMID: 26732568
CD47(high) expression on CD4 effectors identifies functional long-lived memory T cell progenitors. PMID: 22461697
Blocking CD47 shrinks pancreatic tumors. PMID: 25092731
RRx-001, a downregulator of the CD47- SIRPalpha checkpoint pathway, does not cause anemia or thrombocytopenia. PMID: 33432831
Single-cell RNA sequencing study of retinal immune regulators identified CD47 and CD59a expression in photoreceptors-Implications in subretinal immune regulation. PMID: 32166783
Combination of anthracyclines and anti-CD47 therapy inhibit invasive breast cancer growth while preventing cardiac toxicity by regulation of autophagy. PMID: 30056566
Macrophage engulfment of a cell or nanoparticle is regulated by unavoidable opsonization, a species-specific 'Marker of Self' CD47, and target physical properties. PMID: 26172292
Targeting CD47 Enhances the Efficacy of Anti-PD-1 and CTLA-4 in an Esophageal Squamous Cell Cancer Preclinical Model. PMID: 28337964
CD47 blockade as another immune checkpoint therapy for cancer. PMID: 26444633
Restoration of miR-340 controls pancreatic cancer cell CD47 expression to promote macrophage phagocytosis and enhance antitumor immunity. PMID: 32503944
For research use only. Not for human or drug use.
