Catalog No.
YHA50901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gln376
Predicted molecular weight
45.18 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15379
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HD3, SMAP45, RPD3-2, Histone deacetylase 3, HDAC3
Hepatitis B virus core protein promotes liver cancer progression by stabilizing CANX and suppressing IRF7 transcription., PMID:40514420
HDAC7 influences ER-⍺ transcription via NCoR-HDAC3 dissociation., PMID:40513928
Histone Acetylation Modifications and HDACs are Associated with Resilience or Susceptibility to Stress in a Rat Model of Major Depressive Disorder., PMID:40504297
Targeting HDAC3 Suppresses Ferroptosis and Demyelination in White Matter Injury by Restoring PDK4-Mediated Iron Homeostasis., PMID:40485011
Gobal crotonylome reveals that HNRNPC and its crotonylation promote p53-deficient tumor growth by stabilizing CCND1 and MCM3 mRNAs., PMID:40482911
Dual Targeting EZH2 and Histone Deacetylases in Human Uterine Sarcoma Cells Under Both 2D and 3D Culture Conditions., PMID:40464712
Gastrointestinal exposure to silica nanoparticles induced Alzheimer's disease-like neurotoxicity in mice relying on gut microbiota and modulation through TLR4/NF-κB and HDAC., PMID:40457432
Inhibition of histone deacetylases 3 attenuates imiquimod-induced psoriatic dermatitis via targeting cGAS-STING signaling in keratinocytes., PMID:40457335
Macrophage activation determines muscle wasting in pancreatic cancer., PMID:40442475
Ketogenic diet attenuates microglia-mediated neuroinflammation by inhibiting NLRP3 inflammasome activation via HDAC3 inhibition to activate mitophagy in experimental autoimmune encephalomyelitis., PMID:40421817
Design, synthesis, and biological evaluation of N-(2-amino-phenyl)-5-(4-aryl- pyrimidin-2-yl) amino)-1H-indole-2-carboxamide derivatives as novel inhibitors of CDK9 and class I HDACs for cancer treatment., PMID:40383016
Nonproteolytic ubiquitination regulates chromatin occupancy by the NCoR/SMRT/HDAC3 corepressor complex in MCF-7 breast cancer cells., PMID:40305047
Intestinal Butyrate Ameliorates Rheumatoid Arthritis Through Promoting the Expression of Cortistatin in Ileum via HDAC3-Vitamin D Receptor Pathway., PMID:40304573
MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis., PMID:40271828
Design and synthesis of pyridine-based benzamides as potent HDAC3 inhibitors as an armament against breast cancer with in vivo validation., PMID:40267875
[Electroacupuncture improves synaptic plasticity and cognitive dysfunction via down-regulating HDAC3 in mice of Alzheimer's disease]., PMID:40262935
Ji-Ming-San enhances intestinal circadian rhythms and mitigates colitis in mice: The role of epithelial RORα., PMID:40252431
Cold atmospheric plasma drives USP49/HDAC3 axis mediated ferroptosis as a novel therapeutic strategy in endometrial cancer via reinforcing lactylation dependent p53 expression., PMID:40234906
Discovery of Dual PD-L1/HDAC3 Inhibitors for Tumor Immunotherapy., PMID:40230281
Acetylation suppresses breast cancer progression by sustaining CLYBL stability., PMID:40211376
Senkyunolide A interrupts TRAF6-HDAC3 interaction to epigenetically suppress c-MYC and attenuate cholestatic liver injury., PMID:40187727
Reversal of epithelial to mesenchymal transition in triple negative breast cancer through epigenetic modulations by dietary flavonoid Galangin and its combination with SAHA., PMID:40176095
Synthesis and biological evaluation of novel 4-Arylaminoquinolines derivatives as EGFR/HDAC inhibitors., PMID:40164393
Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3., PMID:40140585
Protein post-translational modification crotonylation of TXN and GLO1 in artery and vein grafts for coronary artery surgery., PMID:40138913
Lactylation increases the stability of RBM15 to drives m6A modification in non-small-cell lung cancer cells., PMID:40135634
HDAC3 as an Emerging Therapeutic Target for Alzheimer's Disease and other Neurological Disorders., PMID:40126601
Xinyin tablets affect mitophagy and cardiomyocyte apoptosis to alleviate chronic heart failure by regulating histone deacetylase 3(HDAC3)-mediated PTEN induced putative kinase 1(PINK1)/Parkin signaling pathway., PMID:40122315
The combined effects of HSV-1 glycoprotein D and aluminum hydroxide on human neuroblastoma cells: Insights into oxidative DNA damage, apoptosis, and epigenetic modifications., PMID:40112954
The Role of HDAC3 in Pulmonary Diseases., PMID:40097842
Enhancer Profiling Reveals a Protective Role of RXRα Against Calcium Oxalate-Induced Crystal Deposition and Kidney Injury., PMID:40091688
METTL7B-induced histone lactylation prevents heart failure by ameliorating cardiac remodelling., PMID:40068772
E3 ligase MIB1 regulates STAT1/P21 signaling via regulation of FGFR1 in colorectal cancer., PMID:40063182
The Potential Role of HDAC1 and HDAC3 Immunoexpression in P53 Downregulation and Tumor Aggressiveness of Colon and Rectum Carcinomas Patients., PMID:39985345
Low-dose exposure to microplastics retards meiotic maturation via HDAC3 insufficiency., PMID:39976862
A Feedback Loop Driven by H4K12 Lactylation and HDAC3 in Macrophages Regulates Lactate-Induced Collagen Synthesis in Fibroblasts Via the TGF-β Signaling., PMID:39945346
Regulation of FOXM1 by HDAC3 Inhibition Ameliorates Macrophage Endoplasmic Reticulum stress and Apoptosis in Mycobacterium tuberculosis Infection., PMID:39938455
Discovery of novel biphenyl compounds bearing hydroxamic acid moiety as the first PD-L1/class I HDACs dual inhibitors., PMID:39912413
Anticancer activity of Ilex khasiana, a rare and endemic species of holly in Northeast India, against murine lymphoma., PMID:39885875
RGFP966 inhibits palmitic acid induced VSMCs phenotypic transition by targeting ATGL., PMID:39884383
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation., PMID:39881208
Discovery of Highly Potent and Orally Bioavailable Histone Deacetylase 3 Inhibitors as Immunomodulators and Enhancers of DNA-Damage Response in Cancer Therapy., PMID:39873221
HDAC3 and Snail2 complex promotes melanoma metastasis by epigenetic repression of IGFBP3., PMID:39864688
Discovery of Novel Hydrazide-Based HDAC3 Inhibitors as Epigenetic Immunomodulators for Cancer Immunotherapy., PMID:39847509
MTHFD2 promotes breast cancer cell proliferation through IFRD1 RNA m6A methylation-mediated HDAC3/p53/mTOR pathway., PMID:39832202
PRDX2 induces tumor immune evasion by modulating the HDAC3-Galectin-9 axis in lung adenocarcinoma cells., PMID:39825365
NKAPL facilitates transcription pause-release and bridges elongation to initiation during meiosis exit., PMID:39824811
CPSF6-RARγ interacts with histone deacetylase 3 to promote myeloid transformation in RARG-fusion acute myeloid leukemia., PMID:39805830
Enzyme-independent functions of HDAC3 in the adult heart., PMID:39803453
Proteomic identification of a Toxoplasma gondii sporozoite-specific antigen using HDAC3 inhibitor-treated tachyzoites as surrogate., PMID:39802703
For research use only. Not for human or drug use.
