Catalog No.
PVV01001
Species reactivity
SARS-CoV-2 (2019-nCoV)
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant SARS-CoV-2 NSP1 (Met1-Gly180).
Tested applications
ELISA: 1:4000-1:8000, WB: 1:2000-1:8000
Target
Host translation inhibitor nsp1,Leader protein,Non-structural protein 1,nsp1,Replicase polyprotein 1ab,pp1ab,ORF1ab polyprotein
Purification
Purified by antigen affinity column.
Accession
P0DTD1
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Differential clearance rate of proteins encoded on a self-amplifying mRNA COVID-19 vaccine in muscle and lymph nodes., PMID:40236291
Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms., PMID:39932490
MDA5 Is a Major Determinant of Developing Symptoms in Critically Ill COVID-19 Patients., PMID:39460899
T Cell Peptide Prediction, Immune Response, and Host-Pathogen Relationship in Vaccinated and Recovered from Mild COVID-19 Subjects., PMID:39456150
A safe, effective and adaptable live-attenuated SARS-CoV-2 vaccine to reduce disease and transmission using one-to-stop genome modifications., PMID:38997518
How does a Saccharomyces cerevisiae extract influence the components of isolated rotavirus particles from stool samples collected in a clinical setting from children?, PMID:38946847
Antibody Binding Captures High Energy State of an Antigen: The Case of Nsp1 SARS-CoV-2 as Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry., PMID:38139170
A Novel Rotavirus Reverse Genetics Platform Supports Flexible Insertion of Exogenous Genes and Enables Rapid Development of a High-Throughput Neutralization Assay., PMID:37896813
Comparative whole genome analysis reveals re-emergence of human Wa-like and DS-1-like G3 rotaviruses after Rotarix vaccine introduction in Malawi., PMID:37305707
Intranasal or airborne transmission-mediated delivery of an attenuated SARS-CoV-2 protects Syrian hamsters against new variants., PMID:37296125
The antiviral activity of a small molecule drug targeting the NSP1-ribosome complex against Omicron, especially in elderly patients., PMID:36960047
Targeting viral proteins for restraining SARS-CoV-2: focusing lens on viral proteins beyond spike for discovering new drug targets., PMID:36723288
Active and Passive Immunization of Syrian Hamsters with An Attenuated SARS-CoV-2 Protects against New Variants of Concern., PMID:36380761
Intranasal delivery of a rationally attenuated SARS-CoV-2 is immunogenic and protective in Syrian hamsters., PMID:36357440
Treatment of Sindbis Virus-Infected Neurons with Antibody to E2 Alters Synthesis of Complete and nsP1-Expressing Defective Viral RNAs., PMID:36069441
Structural investigations of proteins encoded by SARS-CoV-2., PMID:36045569
Expression Profile and Localization of SARS-CoV-2 Nonstructural Replicase Proteins in Infected Cells., PMID:35730969
SARS-CoV-2 accessory proteins reveal distinct serological signatures in children., PMID:35618731
SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies., PMID:35587364
Development of Monoclonal Antibodies to Detect for SARS-CoV-2 Proteins., PMID:35405107
A Detailed Overview of Immune Escape, Antibody Escape, Partial Vaccine Escape of SARS-CoV-2 and Their Emerging Variants With Escape Mutations., PMID:35222380
Collection of Monoclonal Antibodies Targeting SARS-CoV-2 Proteins., PMID:35216036
Anti-SARS-CoV-2 IgG responses are powerful predicting signatures for the outcome of COVID-19 patients., PMID:35116173
Immunogenic and antigenic analysis of recombinant NSP1 and NSP11 of PRRS virus., PMID:35023299
Emerging Mutations in Nsp1 of SARS-CoV-2 and Their Effect on the Structural Stability., PMID:34684233
Replication and single-cycle delivery of SARS-CoV-2 replicons., PMID:34648371
Virus-Like Vesicles Based on Semliki Forest Virus-Containing Rabies Virus Glycoprotein Make a Safe and Efficacious Rabies Vaccine Candidate in a Mouse Model., PMID:34346765
Performance assessment of a multi-epitope chimeric antigen for the serological diagnosis of acute Mayaro fever., PMID:34321560
Antibody landscape against SARS-CoV-2 reveals significant differences between non-structural/accessory and structural proteins., PMID:34242574
The SARS-CoV-2 antibody landscape is lower in magnitude for structural proteins, diversified for accessory proteins and stable long-term in children., PMID:33655259
SARS-CoV-2 Proteins: Are They Useful as Targets for COVID-19 Drugs and Vaccines?, PMID:33622224
New-Onset IgG Autoantibodies in Hospitalized Patients with COVID-19., PMID:33532787
Plasmacytoid Dendritic Cells Mediate Control of Ross River Virus Infection via a Type I Interferon-Dependent, MAVS-Independent Mechanism., PMID:33361425
Generation of recombinant rotaviruses encoding a split NanoLuc peptide tag., PMID:33250174
Inactivating Three Interferon Antagonists Attenuates Pathogenesis of an Enteric Coronavirus., PMID:32554697
Overwhelming mutations or SNPs of SARS-CoV-2: A point of caution., PMID:32445924
Comparative Sequence Analysis of Historic and Current Porcine Rotavirus C Strains and Their Pathogenesis in 3-Day-Old and 3-Week-Old Piglets., PMID:32395116
Field porcine reproductive and respiratory syndrome viruses (PRRSV) attenuated by codon pair deoptimization (CPD) in NSP1 protected pigs from heterologous challenge., PMID:31928999
Specific recombinant proteins of porcine epidemic diarrhea virus are immunogenic, revealing their potential use as diagnostic markers., PMID:31500721
Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate., PMID:31015278
Development of an Enzyme-Linked Immunosorbent Assay To Detect Antibodies Targeting Recombinant Envelope Protein 2 of Mayaro Virus., PMID:30787146
Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based assay., PMID:30639438
Development of Stable Rotavirus Reporter Expression Systems., PMID:30541830
Development of an ELISA assay for screening inhibitors against divalent metal ion dependent alphavirus capping enzyme., PMID:29958924
Nsp1α of Porcine Reproductive and Respiratory Syndrome Virus Strain BB0907 Impairs the Function of Monocyte-Derived Dendritic Cells via the Release of Soluble CD83., PMID:29793955
Type I interferon suppression-negative and host mRNA nuclear retention-negative mutation in nsp1β confers attenuation of porcine reproductive and respiratory syndrome virus in pigs., PMID:29402432
The Nucleocapsid Protein and Nonstructural Protein 10 of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Enhance CD83 Production via NF-κB and Sp1 Signaling Pathways., PMID:28659471
Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1., PMID:28619679
Fingolimod treatment abrogates chikungunya virus-induced arthralgia., PMID:28148838
Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex., PMID:27706223
For research use only. Not for human or drug use.
