Catalog No.
YHN51501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr14-Arg372
Predicted molecular weight
43.61 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
B2RXH2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Lysine-specific demethylase 4E, 1.14.11.66, KDM4D-like protein, Lysine-specific demethylase 4D-like, [histone H3]-trimethyl-L-lysine(9) demethylase 4E, KDM4E, KDM4DL
JmjC catalysed histone H2a N-methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships., PMID:39604683
Structural simulation and selective inhibitor discovery study for histone demethylases KDM4E/6B from a computational perspective., PMID:38636391
Baicalein promotes KDM4E to induce BICD1 and inhibit triple-negative breast cancer progression by blocking PAR1 signaling., PMID:38607237
Sex-biased genome-editing effects of CRISPR-Cas9 across cancer cells dependent on p53 status., PMID:37636042
Kinetic and inhibition studies on human Jumonji-C (JmjC) domain-containing protein 5., PMID:37292060
The catalytic domains of all human KDM5 JmjC demethylases catalyse N-methyl arginine demethylation., PMID:36700827
Inhibition of histone demethylase KDM4 by ML324 induces apoptosis through the unfolded protein response and Bim upregulation in hepatocellular carcinoma cells., PMID:34999051
Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer., PMID:34555281
What Is the Catalytic Mechanism of Enzymatic Histone N-Methyl Arginine Demethylation and Can It Be Influenced by an External Electric Field?, PMID:33989435
Relationship of DUX4 and target gene expression in FSHD myocytes., PMID:33502067
Single-cell RNA-seq identifies unique transcriptional landscapes of human nucleus pulposus and annulus fibrosus cells., PMID:32943704
Characterization of Squamous Cell Lung Cancers from Appalachian Kentucky., PMID:30377206
Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis., PMID:29927684
Inhibitors of both the N-methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases., PMID:29685975
Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons., PMID:28459457
Protein arginine methylation: a prominent modification and its demethylation., PMID:28364192
Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells., PMID:28346812
The Activity of JmjC Histone Lysine Demethylase KDM4A is Highly Sensitive to Oxygen Concentrations., PMID:28051298
KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review., PMID:25468267
Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase., PMID:23092293
Kinetic analysis of iron-dependent histone demethylases: α-ketoglutarate substrate inhibition and potential relevance to the regulation of histone demethylation in cancer cells., PMID:23067339
Enabling lead discovery for histone lysine demethylases by high-throughput RapidFire mass spectrometry., PMID:21859681
Inhibition of histone demethylases by 4-carboxy-2,2'-bipyridyl compounds., PMID:21412984
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors., PMID:21124847
Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates., PMID:21076780
Development of homogeneous luminescence assays for histone demethylase catalysis and binding., PMID:20435012
Monitoring the activity of 2-oxoglutarate dependent histone demethylases by NMR spectroscopy: direct observation of formaldehyde., PMID:20095001
For research use only. Not for human or drug use.
