Catalog No.
YHN52001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn32-Tyr148
Predicted molecular weight
29.97 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H1Z8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Augurin, Esophageal cancer-related gene 4 protein, ECRG4, ECRG4, C2orf40, UNQ761/PRO1508
ECRG4 mediates host response to cutaneous infection by regulating neutrophil recruitment and adhesion receptor expression., PMID:39509414
Restoring social deficits in IRSp53-deleted mice: chemogenetic inhibition of ventral dentate gyrus Emx1-expressing cells., PMID:39375329
Complex and pleiotropic signaling pathways regulated by the secreted protein augurin., PMID:37041625
Esophageal cancer-related gene 4 inhibits gastric cancer growth and metastasis by upregulating Krüppel-like factor 2 expression., PMID:36923086
Esophageal cancer-related gene 4 and solid tumors: a brief literature review., PMID:36696238
UBR5 promotes migration and invasion of glioma cells by regulating the ECRG4/NF-ҡB pathway., PMID:36226349
The ECRG4 cleavage product augurin binds the endotoxin receptor and influences the innate immune response during otitis media., PMID:36092940
C2orf40 inhibits metastasis and regulates chemo-resistance and radio-resistance of nasopharyngeal carcinoma cells by influencing cell cycle and activating the PI3K/AKT/mTOR signaling pathway., PMID:35676661
Cardiac Expression of Esophageal Cancer-Related Gene-4 is Regulated by Sp1 and is a Potential Early Target of Doxorubicin-Induced Cardiotoxicity., PMID:35129819
Dysregulation of ECRG4 is associated with malignant properties and of prognostic importance in human gastric cancer., PMID:34657878
Brain endothelial cells-derived extracellular vesicles overexpressing ECRG4 inhibit glioma proliferation through suppressing inflammation and angiogenesis., PMID:34551201
C2orf40 inhibits hepatocellular carcinoma through interaction with UBR5., PMID:33576531
MicroRNA-196b promotes gastric cancer progression by targeting ECRG4., PMID:33417325
Efficacy of nedaplatin combined with docetaxel in patients with nasopharyngeal carcinoma and its influence on ECRG4 and VEGF expressions., PMID:33099941
ECRG4 Represses Cell Proliferation and Invasiveness via NFIC/OGN/NF-κB Signaling Pathway in Bladder Cancer., PMID:32922434
ECRG4 regulates neutrophil recruitment and CD44 expression during the inflammatory response to injury., PMID:32195341
ITIH5 and ECRG4 DNA Methylation Biomarker Test (EI-BLA) for Urine-Based Non-Invasive Detection of Bladder Cancer., PMID:32046186
Towards the early detection of ductal carcinoma (a common type of breast cancer) using biomarkers linked to the PPAR(γ) signaling pathway., PMID:31902979
Potential functions of esophageal cancer-related gene-4 in the cardiovascular system., PMID:31468282
Open reading frame mining identifies a TLR4 binding domain in the primary sequence of ECRG4., PMID:31190084
Esophageal cancer related gene-4 inhibits the migration and proliferation of oral squamous cell carcinoma through BC200 lncRNA/MMP-9 and -13 signaling pathway., PMID:31152845
ECRG4 acts as a tumor suppressor gene frequently hypermethylated in human breast cancer., PMID:30918105
Ecrg4 deficiency extends the replicative capacity of neural stem cells in a Foxg1-dependent manner., PMID:30745428
ECRG4: a new potential target in precision medicine., PMID:30003403
Serum exosomes contain ECRG4 mRNA that suppresses tumor growth via inhibition of genes involved in inflammation, cell proliferation, and angiogenesis., PMID:29983418
Rare genetic mutations in Pakistani patients with dilated cardiomyopathy., PMID:29886034
Ecrg4 peptide is the ligand of multiple scavenger receptors., PMID:29511297
Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease., PMID:29458411
UBE2C is involved in the functions of ECRG4 on esophageal squamous cell carcinoma., PMID:29268240
The unrecognized role of tumor suppressor genes in atrial fibrillation., PMID:29126922
Downregulation of esophageal cancer-related gene 4 promotes proliferation and migration of hepatocellular carcinoma., PMID:28927132
Counter regulation of ECRG4 gene expression by hypermethylation-dependent inhibition and the Sp1 transcription factor-dependent stimulation of the c2orf40 promoter., PMID:28870864
Association of ECRG4 with PLK1, CDK4, PLOD1 and PLOD2 in esophageal squamous cell carcinoma., PMID:28861165
UBR5 Contributes to Colorectal Cancer Progression by Destabilizing the Tumor Suppressor ECRG4., PMID:28856538
A Potential Role of Esophageal Cancer Related Gene-4 for Atrial Fibrillation., PMID:28578429
A short synthetic peptide fragment of human C2ORF40 has therapeutic potential in breast cancer., PMID:28410214
The Orphan C2orf40 Gene is a Neuroimmune Factor in Alzheimer's Disease., PMID:27990492
Beclin 1 promotes apoptosis and decreases invasion by upregulating the expression of ECRG4 in A549 human lung adenocarcinoma cells., PMID:27175789
Downregulated ECRG4 is correlated with lymph node metastasis and predicts poor outcome for nasopharyngeal carcinoma patients., PMID:27119734
Expression of esophageal carcinoma related gene 4 (ECRG4) and its clinical significance in prognosis of esophageal carcinoma., PMID:26823803
ECRG4 as a novel tumor suppressor gene inhibits colorectal cancer cell growth in vitro and in vivo., PMID:26762416
[Expression and function of ECRG4 in hepatocellular carcinoma]., PMID:26705039
Down-regulated ECRG4 expression in breast cancer and its correlation with tumor progression and poor prognosis--A short Report., PMID:26631111
Monitoring Neutrophil-Expressed Cell Surface Esophageal Cancer Related Gene-4 after Severe Burn Injury., PMID:26460850
Downregulated ECRG4 is associated with poor prognosis in renal cell cancer and is regulated by promoter DNA methylation., PMID:26276361
A preliminary study of the effect of ECRG4 overexpression on the proliferation and apoptosis of human laryngeal cancer cells and the underlying mechanisms., PMID:26165988
ECRG4 expression in normal rat tissues: expression study and literature review., PMID:26150152
Synthesis of β-Thiol Phenylalanine for Applications in One-Pot Ligation-Desulfurization Chemistry., PMID:25860301
ECRG4 acts as a tumor suppressor and as a determinant of chemotherapy resistance in human nasopharyngeal carcinoma., PMID:25707757
Esophageal cancer-related gene 4 at the interface of injury, inflammation, infection, and malignancy., PMID:25580077
For research use only. Not for human or drug use.
