Catalog No.
PHK79401
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human HCN2 (Gly524-Leu713).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
HCN2, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, BCNG-2, Brain cyclic nucleotide-gated channel 2, BCNG2
Purification
Purified by antigen affinity column.
Accession
Q9UL51
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Peripheral Voltage-Gated Cation Channels in Neuropathic Pain and Their Potential as Therapeutic Targets., PMID:35295464
HCN3 ion channels: roles in sensory neuronal excitability and pain., PMID:31290157
Expression and cellular localization of HCN channels in rat cerebellar granule neurons., PMID:27569278
Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's disease., PMID:25987789
Myocardial expression of hyperpolarization-activated, cyclic nucleotide-gated proteins in healthy cats and cats with hypertrophic cardiomyopathy., PMID:23385073
The distribution of HCN2-positive cells in the gastrointestinal tract of mice., PMID:22803609
Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart., PMID:21945247
The hyperpolarization-activated cyclic nucleotide-gated HCN2 channel transports ammonium in the distal nephron., PMID:21796099
Diabetes alters protein expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits in rat nodose ganglion cells., PMID:19815055
Proteolytic processing of HCN2 and co-assembly with HCN4 in the generation of cardiac pacemaker channels., PMID:19574228
Transcriptional control of pacemaker channel genes HCN2 and HCN4 by Sp1 and implications in re-expression of these genes in hypertrophied myocytes., PMID:19471099
In situ co-distribution and functional interactions of SAP97 with sinoatrial isoforms of HCN channels., PMID:19336273
Involvement of hyperpolarization-activated, cyclic nucleotide-gated cation channels in dorsal root ganglion in neuropathic pain., PMID:18958363
Hyperpolarization-activated cyclic nucleotide-gated channel mRNA and protein expression in large versus small diameter dorsal root ganglion neurons: correlation with hyperpolarization-activated current gating., PMID:18450385
Proteasome inhibitors increase tubulin polymerization and stabilization in tissue culture cells: a possible mechanism contributing to peripheral neuropathy and cellular toxicity following proteasome inhibition., PMID:18414063
A subpopulation of capsaicin-sensitive porcine dorsal root ganglion neurons is lacking hyperpolarization-activated cyclic nucleotide-gated channels., PMID:18218331
A hyperpolarization-activated, cyclic nucleotide-gated, (Ih-like) cationic current and HCN gene expression in renal inner medullary collecting duct cells., PMID:18199706
Activity-dependent regulation of h channel distribution in hippocampal CA1 pyramidal neurons., PMID:17848552
Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2., PMID:17074978
Expression of hyperpolarization-activated cyclic nucleotide-gated cation channels in rat dorsal root ganglion neurons innervating urinary bladder., PMID:16979600
Hyperpolarization-activated cation channels are expressed in rat hypothalamic gonadotropin-releasing hormone (GnRH) neurons and immortalized GnRH neurons., PMID:16879992
The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides., PMID:15923185
Distribution of HCN1 and HCN2 in rat auditory brainstem nuclei., PMID:15245481
Hyperpolarization-activated, cyclic nucleotide-gated cation channels: roles in the differential electrophysiological properties of rat primary afferent neurons., PMID:15139030
A comparative study of the effect of oxidative stress on the cytoskeleton in human cortical neurons., PMID:15050405
For research use only. Not for human or drug use.
