Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Study of the Penetration of a Monoclonal Antibody Combination (ASN100) Targeting Staphylococcus aureus Cytotoxins in the Lung Epithelial Lining Fluid of Healthy Volunteers., PMID:31138568
Role and plasticity of Th1 and Th17 responses in immunity to Staphylococcus aureus., PMID:31149870
Candida albicans Augments Staphylococcus aureus Virulence by Engaging the Staphylococcal agr Quorum Sensing System., PMID:31164467
Rational Design of Toxoid Vaccine Candidates for Staphylococcus aureus Leukocidin AB (LukAB)., PMID:31207937
Sono-Immunotherapeutic Nanocapturer to Combat Multidrug-Resistant Bacterial Infections., PMID:31222947
Survival during influenza-associated bacterial superinfection improves following viral- and bacterial-specific monoclonal antibody treatment., PMID:31341107
Associations of pathogen-specific and host-specific characteristics with disease outcome in patients with Staphylococcus aureus bacteremic pneumonia., PMID:31360464
Efficacy of Active Immunization With Attenuated α-Hemolysin and Panton-Valentine Leukocidin in a Rabbit Model of Staphylococcus aureus Necrotizing Pneumonia., PMID:31504652
Effects of isosorbide mononitrate loaded nanoparticles conjugated with anti-Staphylococcus aureus α-toxin on Staphylococcus aureus biofilms., PMID:32010298
Design of Staphylococcus aureus New Vaccine Candidates with B and T Cell Epitope Mapping, Reverse Vaccinology, and Immunoinformatics., PMID:32286190
Vaccination with VLPs Presenting a Linear Neutralizing Domain of S. aureus Hla Elicits Protective Immunity., PMID:32664481
Antibody-Mediated Protection against Staphylococcus aureus Dermonecrosis: Synergy of Toxin Neutralization and Neutrophil Recruitment., PMID:32946878
Development of a mechanism of action reflective and robust potency assay for a therapeutic antibody against alpha toxin using rabbit erythrocytes., PMID:33075362
IBT-V02: A Multicomponent Toxoid Vaccine Protects Against Primary and Secondary Skin Infections Caused by Staphylococcus aureus., PMID:33777005
Identification and application of a neutralizing epitope within alpha-hemolysin using human serum antibodies elicited by vaccination., PMID:33873093
Efficacy and safety of suvratoxumab for prevention of Staphylococcus aureus ventilator-associated pneumonia (SAATELLITE): a multicentre, randomised, double-blind, placebo-controlled, parallel-group, phase 2 pilot trial., PMID:33894131
Multimechanistic Monoclonal Antibody Combination Targeting Key Staphylococcus aureus Virulence Determinants in a Rabbit Model of Prosthetic Joint Infection., PMID:33903108
Immunodominance of Epitopes and Protective Efficacy of HI Antigen Are Differentially Altered Using Different Adjuvants in a Mouse Model of Staphylococcus aureus Bacteremia., PMID:34122448
Impaired T-Lymphocyte Responses During Childhood Staphylococcus aureus Infection., PMID:34145461
Development of Combination Vaccine Conferring Optimal Protection against Six Pore-Forming Toxins of Staphylococcus aureus., PMID:34227839
Identification of a Human Anti-Alpha-Toxin Monoclonal Antibody Against Staphylococcus aureus Infection., PMID:34335518
Bacterial Type I Toxins: Folding and Membrane Interactions., PMID:34357962
Antibiotic Combined with Epitope-Specific Monoclonal Antibody Cocktail Protects Mice Against Bacteremia and Acute Pneumonia from Methicillin-Resistant Staphylococcus aureus Infection., PMID:34511967
Immunoinformatics analysis and evaluation of recombinant chimeric triple antigen toxoid (r-HAB) against Staphylococcus aureus toxaemia in mouse model., PMID:34609523
[Preparation and functional identification of human single chain recombinant antibody targeting α-hemolysin of Staphylococcus aureus]., PMID:34906299
Efficacy of immunization with a recombinant S. aureus vaccine formulated with liposomes and ODN-CpG against natural S. aureus intramammary infections in heifers and cows., PMID:35219182
Antibiotic Treatment of Staphylococcus aureus Infection Inhibits the Development of Protective Immunity., PMID:35266822
Capture and identification of bacteria from fish muscle based on immunomagnetic beads and MALDI-TOF MS., PMID:35498980
Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin., PMID:35587511
Neutralizing Staphylococcus aureus Virulence with AZD6389, a Three mAb Combination, Accelerates Closure of a Diabetic Polymicrobial Wound., PMID:35642538
A novel fully human recombinant antibody neutralizing α-hemolysin of Staphylococcus aureus., PMID:35751523
Performance of the Cepheid Methicillin-Resistant Staphylococcus aureus/S. aureus Skin and Soft Tissue Infection PCR Assay on Respiratory Samples from Mechanically Ventilated Patients for S. aureus Screening during the Phase 2 Double-Blind SAATELLITE Study., PMID:35758652
Staphylococcus aureus Alpha-Toxin in Deep Tracheal Aspirates-Preliminary Evidence for Its Presence in the Lungs of Sepsis Patients., PMID:35878188
A novel gyrase inhibitor from toxin-antitoxin system expressed by Staphylococcus aureus., PMID:36148483
Identification of two neutralizing human single-chain variable fragment antibodies targeting Staphylococcus aureus alpha-hemolysin., PMID:36311199
New Molecular and Biological Markers in Cutaneous T Cell Lymphoma: Therapeutic Implications., PMID:37017872
Anti-Alpha-Toxin Antibody Responses and Clinical Outcomes of Staphylococcus aureus Bacteremia., PMID:37096312
Mechanism of Action for an All-in-One Monoclonal Antibody Against Staphylococcus aureus Infection., PMID:37335928
Monoclonal antibodies neutralizing alpha-hemolysin, bicomponent leukocidins, and clumping factor A protected against Staphylococcus aureus-induced acute circulatory failure in a mechanically ventilated rabbit model of hyperdynamic septic shock., PMID:37781371
A randomised, double-blind, placebo-controlled, first-in-human phase I study to characterise the safety, pharmacokinetics and immunogenicity of 9MW1411 in healthy Chinese subjects., PMID:38157918
Toxin-neutralizing Abs are associated with improved T cell function following recovery from Staphylococcus aureus infection., PMID:38236641
Investigation of Staphylococcus aureus Biofilm-Associated Toxin as a Potential Squamous Cell Carcinoma Therapeutic., PMID:38399697
Facile construction of sandwich ELISA based on double-nanobody for specific detection of α-hemolysin in food samples., PMID:38569370
In Vivo Detection of Staphylococcus aureus Infections Using Radiolabeled Antibodies Specific for Bacterial Toxins., PMID:38665417
A High-Homology Region Provides the Possibility of Detecting β-Barrel Pore-Forming Toxins from Various Bacterial Species., PMID:38791367
In vivo mRNA expression of a multi-mechanistic mAb combination protects against Staphylococcus aureus infection., PMID:38822525
α-Hemolysin-mediated endothelial injury contributes to the development of Staphylococcus aureus-induced dermonecrosis., PMID:38953668
Enhanced Staphylococcus aureus protection by uncoupling of the α-toxin-ADAM10 interaction during murine neonatal vaccination., PMID:39379345
Highly sensitive detection of Staphylococcus aureus α-hemolysin protein (Hla or α-toxin) by apta-qPCR., PMID:39742925
Imaging oligomers of alpha-toxin (Hla) variants using high-speed AFM and neutralizing Hla hemolytic activity with their antisera., PMID:40147500
For research use only. Not for human or drug use.
