Research Grade Foralumab (DHC27705)

Catalog No.

DHC27705

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

T3E, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T-cell surface glycoprotein CD3 epsilon chain

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P07766

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

NI-0401, CAS: 946415-64-1

Clone ID

Foralumab

Therapeutic anti-CD3 monoclonal antibodies: from bench to bedside, PMID: 27161438

Targeting T cells in inflammatory bowel disease, PMID: 32585338

Oral treatment with foralumab, a fully human anti-CD3 monoclonal antibody, prevents skin xenograft rejection in humanized mice, PMID: 28739191

Combination therapies in the context of anti-CD3 antibodies for the treatment of autoimmune diseases, PMID: 23254986

Immunotherapy with oral administration of humanized anti-CD3 monoclonal antibody: a novel gut-immune system-based therapy for metaflammation and NASH, PMID: 29920654

Preclinical efficacy of humanized, non-FcγR-binding anti-CD3 antibodies in T-cell acute lymphoblastic leukemia, PMID: 32483610

Document Download

Research Grade Foralumab.pdf