Catalog No.
DHD42201
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Applications
Research Grade Biosimilar
Target
Adipogenesis inhibitory factor, AGIF, IL11, IL-11, Interleukin-11, Oprelvekin
Concentration
3.12 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P20809
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
EnX203, EnX 203, EnX-203, X203
Clone ID
X203
Note
For research use only. Not suitable for clinical or therapeutic use.
The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling., PMID:34435951
WNT/β-Catenin Signaling Promotes TGF-β-Mediated Activation of Human Cardiac Fibroblasts by Enhancing IL-11 Production., PMID:34576234
Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts., PMID:34651016
A neutralizing IL-11 antibody reduces vessel hyperplasia in a mouse carotid artery wire injury model., PMID:34667238
Exclusive inhibition of IL-6 trans-signaling by soluble gp130FlyRFc., PMID:34927050
Therapeutic opportunities for senolysis in cardiovascular disease., PMID:35015342
Inhibition of IL11 Signaling Reduces Aortic Pathology in Murine Marfan Syndrome., PMID:35135328
A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome., PMID:35140116
IL-11 Is Elevated and Drives the Profibrotic Phenotype Transition of Orbital Fibroblasts in Thyroid-Associated Ophthalmopathy., PMID:35273577
Interleukin-11 drives human and mouse alcohol-related liver disease., PMID:35365572
IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis., PMID:35408908
[Analysis of immune inflammation-related proteins in serum of patients with rheumatoid arthritis and the regulatory effect of Xinfeng Capsule on cytokines]., PMID:35603652
[Correlation between Serum miR-34a Level and Thrombocytopenia after Chemotherapy in Patients with Diffuse Large B-Cell Lymphoma]., PMID:35680806
Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge., PMID:35731866
Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury., PMID:35806094
Development of novel ultra-sensitive IL-11 target engagement assays to support mechanistic PK/PD modeling for an anti-IL-11 antibody therapeutic., PMID:35916739
IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells., PMID:35992082
IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues., PMID:36012165
Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease., PMID:36470928
Neutralization of interleukin-11 attenuates silica particles-induced pulmonary inflammation and fibrosis in vivo., PMID:36503802
IL-11 drives the phenotypic transformation of tracheal epithelial cells and fibroblasts to enhance abnormal repair after tracheal injury., PMID:36758859
IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome., PMID:36924234
Targeting carcinoma-associated mesothelial cells with antibody-drug conjugates in ovarian carcinomatosis., PMID:37555348
Efficacy, safety, and biomarker analysis of nivolumab in combination with abemaciclib plus endocrine therapy in patients with HR-positive HER2-negative metastatic breast cancer: a phase II study (WJOG11418B NEWFLAME trial)., PMID:37709297
Interleukin-11 and its eminent role in tissue fibrosis: a possible therapeutic target., PMID:37724596
Targeting IL-11 system as a treatment of pulmonary arterial hypertension., PMID:37949331
Bazedoxifene Suppresses the Growth of Osteosarcoma Cells by Inhibiting IL-6 and IL-11/GP130 Signaling Pathway., PMID:37962127
Cytokines of the interleukin-6 family as emerging targets in inflammatory bowel disease., PMID:38217849
Protein kinase D drives the secretion of invasion mediators in triple-negative breast cancer cell lines., PMID:38323010
Nonspecific Inhibition of IL6 Family Cytokine Signalling by Soluble gp130., PMID:38338642
Cardiac and Renal Fibrosis, the Silent Killer in the Cardiovascular Continuum: An Up-to-Date., PMID:38392276
IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFβ., PMID:38455057
Potential therapeutic targets of fibrosis in inflammatory rheumatic diseases., PMID:38627168
Targeting IL-11R/EZH2 signaling axis as a therapeutic strategy for osteosarcoma lung metastases., PMID:38886296
Bevacizumab-induced immune thrombocytopenia in an ovarian cancer patient with mixed connective tissue disease: case report and literature review., PMID:38903494
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan., PMID:39020175
Analytical and Clinical Validation of an Automated Microfluidic Interleukin-6 Immunoassay., PMID:39048159
Anti-IL-11 antibody shows anti-ageing properties., PMID:39090176
Optimized inhaled LNP formulation for enhanced treatment of idiopathic pulmonary fibrosis via mRNA-mediated antibody therapy., PMID:39122711
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing., PMID:39381601
Interleukin-11 receptor is an alternative α-receptor for interleukin-6 and the chimeric cytokine IC7., PMID:39473075
Prevent and Reverse Metabolic Dysfunction-Associated Steatohepatitis and Hepatic Fibrosis via mRNA-Mediated Liver-Specific Antibody Therapy., PMID:39639502
De novo discovery of cyclic peptide inhibitors of IL-11 signaling., PMID:39756345
Long-term increase in soluble interleukin-6 receptor levels in convalescents after mild COVID-19 infection., PMID:39835136
Site-specific immunoglobulin G N-glycosylation is associated with gastric cancer progression., PMID:39920693
Interleukin-11 expressed in the polyp-enriched fibroblast subset is a potential therapeutic target in Peutz-Jeghers syndrome., PMID:40070038
AHR Agonist ITE Boosted PD1 Antibody's Effects by Inhibiting Myeloid-Derived Cells Suppressive Cells in an Orthotopic Mouse Glioma Model., PMID:40283908
IL-11/IL-11R signal inhibition by 9MW3811 remodels immune tumor microenvironment and enhances anti-tumor efficacy of PD-1 blockade., PMID:40355638
Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity., PMID:40399681
The Use of Biologics for Thyroid Eye Disease., PMID:40478400
Targeting VSIG4+ tissue-resident macrophages enhances T cell cytotoxicity and immunotherapy efficacy in cancer. [DHD42201]
For research use only. Not for human or drug use.
