Catalog No.
RHE27701
Description
The signal transducer and activator of transcription 3 (STAT3) is a transcription factor mainly activated by phosphorylation in either tyrosine 705 (Y705, AAP(pY)LKTK) or serine 727 (S727) residues that regulates essential processes such as cell differentiation, apoptosis inhibition, or cell survival.
Species reactivity
Human, Mouse
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Applications
ELISA, IP, WB
Target
Signal transducer and activator of transcription 3, APRF, STAT3, Acute-phase response factor
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P40763
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0302
Note
For research use only.
Cancer-related inflammation and Barrett's carcinogenesis: interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett's cells., PMID:21148399
Anti-dermatitis effects of oak wood vinegar on the DNCB-induced contact hypersensitivity via STAT3 suppression., PMID:21511023
HGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop., PMID:21595927
Nuclear localization of activated STAT6 and STAT3 in epidermis of prurigo nodularis., PMID:21711341
Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma: implications for therapy., PMID:22116549
Dovitinib sensitizes hepatocellular carcinoma cells to TRAIL and tigatuzumab, a novel anti-DR5 antibody, through SHP-1-dependent inhibition of STAT3., PMID:22230479
Cell-type-specific expression of STAT transcription factors in tissue samples from patients with lymphocytic thyroiditis., PMID:22527947
Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12., PMID:22530037
Innate immune responses involving natural killer and natural killer T cells promote liver regeneration after partial hepatectomy in mice., PMID:23086918
Lactobacillus rhamnosus (LGG) regulates IL-10 signaling in the developing murine colon through upregulation of the IL-10R2 receptor subunit., PMID:23272193
STAT3 but not STAT1 is required for astrocyte differentiation., PMID:24466267
The amelioration of phagocytic ability in microglial cells by curcumin through the inhibition of EMF-induced pro-inflammatory responses., PMID:24645646
Interleukin-17 increases the expression of Toll-like receptor 3 via the STAT3 pathway in rheumatoid arthritis fibroblast-like synoviocytes., PMID:24708416
Polarization of prostate cancer-associated macrophages is induced by milk fat globule-EGF factor 8 (MFG-E8)-mediated efferocytosis., PMID:25006249
TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways., PMID:25192910
CCR5 Blockade Suppresses Melanoma Development Through Inhibition of IL-6-Stat3 Pathway via Upregulation of SOCS3., PMID:26047948
Anti-proliferative action of IL-6R-targeted antibody tocilizumab for non-small cell lung cancer cells., PMID:26137057
Bidirectional role of IL-6 signal in pathogenesis of lung fibrosis., PMID:26289430
Obesity decreases B cell responses in young and elderly individuals., PMID:26857091
Expression of biologically active bovine interleukin 7 and evaluating the activity in vitro., PMID:27051202
Modeling anti-IL-6 therapy using breast cancer patient-derived xenografts., PMID:27602583
Role of mTOR signaling pathway in the pathogenesis of subependymal giant cell astrocytoma - A study of 28 cases., PMID:27625244
The immunomodulatory effects of TNF-α inhibitors on human Th17 cells via RORγt histone acetylation., PMID:27926504
IL-6-specific autoantibodies among APECED and thymoma patients., PMID:27957331
The role of local IL6/JAK2/STAT3 signaling in high glucose-induced podocyte hypertrophy., PMID:27957415
Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model., PMID:27980102
The role of STAT3 and AhR in the differentiation of CD4+ T cells into Th17 and Treg cells., PMID:28445259
C-X-C motif chemokine receptor 4 promotes tumor angiogenesis in gastric cancer via activation of JAK2/STAT3., PMID:28544312
Impairment of Hepcidin Upregulation by Lipopolysaccharide in the Interleukin-6 Knockout Mouse Brain., PMID:29163042
Red nucleus interleukin-6 participates in the maintenance of neuropathic pain through JAK/STAT3 and ERK signaling pathways., PMID:29183675
An Interleukin-6 Receptor Antibody Suppresses Atherosclerosis in Atherogenic Mice., PMID:29312959
Up-Regulation of CX3CL1 via STAT3 Contributes to SMIR-Induced Chronic Postsurgical Pain., PMID:29313211
Celastrol mediates Th17 and Treg cell generation via metabolic signaling., PMID:29476742
Interleukin-6 receptor inhibitor suppresses bone metastases in a breast cancer cell line., PMID:29557068
Red nucleus interleukin-1β evokes tactile allodynia through activation of JAK/STAT3 and JNK signaling pathways., PMID:30216497
Leukemia inhibitory factor functions in parallel with interleukin-6 to promote ovarian cancer growth., PMID:30305729
Interleukin-22 Promotes Osteosarcoma Cell Proliferation and Invasion via STAT3 Activation., PMID:30381753
IL-37 attenuates allergic process via STAT6/STAT3 pathways in murine allergic rhinitis., PMID:30665041
IL-6-PAD4 axis in the earliest phase of arthritis in knock-in gp130F759 mice, a model for rheumatoid arthritis., PMID:31321075
Snail expression contributes to temozolomide resistance in glioblastoma., PMID:31396334
Physiological strength electric fields modulate human T cell activation and polarisation., PMID:31772211
TGF-β pathway activation by idiopathic pulmonary fibrosis (IPF) fibroblast derived soluble factors is mediated by IL-6 trans-signaling., PMID:32070329
Phloretin Modulates Human Th17/Treg Cell Differentiation In Vitro via AMPK Signaling., PMID:32802861
LRP8 activates STAT3 to induce PD-L1 expression in osteosarcoma., PMID:33054597
Acute FPIES reactions are associated with an IL-17 inflammatory signature., PMID:33891982
G-CSF and IL-6 may be involved in formation of endometriosis lesions by increasing the expression of angiogenic factors in neutrophils., PMID:34643696
Luteolin suppresses the growth of colon cancer cells by inhibiting the IL-6/STAT3 signaling pathway., PMID:36092354
Activation of STAT3 (signal transducer and activator of transcription 3) in synovial tissues from the hip joint in the early stage of rapidly destructive coxopathy., PMID:36244795
Maternal pre-eclampsia serum increases neurite growth and mitochondrial function through a potential IL-6-dependent mechanism in differentiated SH-SY5Y cells., PMID:36714304
NF-κB and STAT3 activation in CD4 T cells in pediatric MOG antibody-associated disease., PMID:37770354
Emodin inhibits bladder inflammation and fibrosis in mice with interstitial cystitis by regulating JMJD3. [RHE27701]
For research use only. Not for human or drug use.
