Catalog No.
RHH20001
Species reactivity
Human, Mouse, Rat, Bovine, Sumatran orangutan, Zebrafish
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Applications
IHC, IP, WB
Target
Mothers against decapentaplegic homolog 2, SMAD 2, SMAD2, JV18-1, Mad-related protein 2, hMAD-2, MADR2, Mothers against DPP homolog 2, SMAD family member 2, MADH2, Smad2, hSMAD2, MAD homolog 2
Concentration
1.98 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q15796
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
P4.B9
Note
For research use only.
Endogenous patterns of TGFbeta superfamily signaling during early Xenopus development., PMID:10851136
Sustained activation of fibroblast transforming growth factor-beta/Smad signaling in a murine model of scleroderma., PMID:12839562
Profile of transforming growth factor-beta responses during the murine hair cycle., PMID:14708594
Acute allergen-induced airway remodeling in atopic asthma., PMID:15333330
BMP and activin receptor expression in lens development., PMID:15346106
Pioglitazone induces vascular smooth muscle cell apoptosis through a peroxisome proliferator-activated receptor-gamma, transforming growth factor-beta1, and a Smad2-dependent mechanism., PMID:15734860
Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct., PMID:16643884
The synthetic triterpenoid CDDO-imidazolide induces monocytic differentiation by activating the Smad and ERK signaling pathways in HL60 leukemia cells., PMID:16818503
Extracellular matrix-mediated membrane-type 1 matrix metalloproteinase expression in pancreatic ductal cells is regulated by transforming growth factor-beta1., PMID:16849548
TGF-beta-neutralizing antibodies improve pulmonary alveologenesis and vasculogenesis in the injured newborn lung., PMID:17400601
RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells., PMID:17638924
Thrombospondin-1 is an endogenous activator of TGF-beta in experimental diabetic nephropathy in vivo., PMID:17878288
A sensitive detection of phospho-Smad1/5/8 and Smad2 in Western blot analyses., PMID:17976733
Induction of initial heart alpha-actin, smooth muscle alpha-actin, in chick pregastrula epiblast: the role of hypoblast and fibroblast growth factor-8., PMID:18312428
Role of increased penile expression of transforming growth factor-beta1 and activation of the Smad signaling pathway in erectile dysfunction in streptozotocin-induced diabetic rats., PMID:18778311
Transforming growth factor-beta signaling at the tumor-bone interface promotes mammary tumor growth and osteoclast activation., PMID:19038005
Inhibitory effect of blocking TGF-beta/Smad signal on injury-induced fibrosis of corneal endothelium., PMID:19081766
Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts., PMID:19171760
Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling., PMID:19351925
Palifermin induces alveolar maintenance programs in emphysematous mice., PMID:20007933
Transforming growth factor (TGF)-β type I receptor kinase (ALK5) inhibitor alleviates profibrotic TGF-β1 responses in fibroblasts derived from Peyronie's plaque., PMID:20233292
Tranilast modulates fibrosis, epithelial-mesenchymal transition and peritubular capillary injury in unilateral ureteral obstruction rats., PMID:20854076
Increased cavernous expression of transforming growth factor-β1 and activation of the Smad signaling pathway affects erectile dysfunction in men with spinal cord injury., PMID:20946170
TSC-22 promotes transforming growth factor β-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity., PMID:21791611
Spatiotemporal disorder in the axial skeleton development of the Mesp2-null mouse: a model of spondylocostal dysostosis and spondylothoracic dysostosis., PMID:23238123
IgG4-related skin disease successfully treated by thalidomide: a report of 2 cases with emphasis on pathological aspects., PMID:23572226
Mammary epithelial cell interactions with fibronectin stimulate epithelial-mesenchymal transition., PMID:23624917
Smad7 foci are present in micronuclei induced by heavy particle radiation., PMID:23643526
Inhibition of histone deacetylase 2 mitigates profibrotic TGF-β1 responses in fibroblasts derived from Peyronie's plaque., PMID:23770939
HRG-β1-driven ErbB3 signaling induces epithelial-mesenchymal transition in breast cancer cells., PMID:23937725
A novel epidermal growth factor receptor-signaling platform and its targeted translation in pancreatic cancer., PMID:23993964
Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-β., PMID:25707005
Reactive Oxygen Species and p38MAPK Have a Role in the Smad2 Linker Region Phosphorylation Induced by TGF-β., PMID:30046209
KLF4 Regulates Corneal Epithelial Cell Cycle Progression by Suppressing Canonical TGF-β Signaling and Upregulating CDK Inhibitors P16 and P27., PMID:30786277
Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation., PMID:31290007
Activin A overexpression promotes rat follicular development through SCF-kit-mediated cell signals., PMID:32133888
Anti-epileptic drug topiramate upregulates TGFβ1 and SOX9 expression in primary embryonic palatal mesenchyme cells: Implications for teratogenicity., PMID:33577554
Endoplasmic reticulum stress inhibits 3D Matrigel-induced vasculogenic mimicry of breast cancer cells via TGF-β1/Smad2/3 and β-catenin signaling., PMID:34320274
Endothelin-1 Induced Phosphorylation of Caveolin-1 and Smad2C in Human Vascular Smooth Muscle Cells: Role of NADPH Oxidases, c-Abl, and Caveolae Integrity in TGF-β Receptor Transactivation., PMID:37727643
Endothelin-1 Stimulates PAI-1 Protein Expression via Dual Transactivation Pathway Dependent ROCK and Phosphorylation of Smad2L., PMID:36093806
For research use only. Not for human or drug use.
