Research Grade Pateclizumab (DHB94301)

Catalog No.

DHB94301

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG1-kappa

Clonality

Monoclonal

Target

TNF-beta, TNFSF1, Tumor necrosis factor ligand superfamily member 1, LTA, Lymphotoxin-alpha, LT-alpha, TNFB

Concentration

1.74 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P01374

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

MLTA3698A, PRO283698, RG7416, CAS: 1202526-59-7

Clone ID

Pateclizumab

A novel immunoassay to measure total serum lymphotoxin-α levels in the presence of an anti-LTα therapeutic antibody, PMID: 26009247

Assessment of placental transfer and the effect on embryo-fetal development of a humanized monoclonal antibody targeting lymphotoxin-alpha in non-human primates, PMID: 27211603

Efficacy and safety of pateclizumab (anti-lymphotoxin-α) compared to adalimumab in rheumatoid arthritis: a head-to-head phase 2 randomized controlled study (The ALTARA Study), PMID: 25359150

Safety, pharmacokinetics, and biologic activity of pateclizumab, a novel monoclonal antibody targeting lymphotoxin α: results of a phase I randomized, placebo-controlled trial, PMID: 22225620

The role of lymphotoxin-α in rheumatoid arthritis, PMID: 29541795

Document Download

Research Grade Pateclizumab.pdf