Anti-DRP1/DNM1L Polyclonal Antibody

Catalog No.

PHA11501

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human DRP1/DNM1L (Met1-Arg516).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Dynamin family member proline-rich carboxyl-terminal domain less,DVLP,Dynamin-like protein IV,Dynamin-related protein 1,Dynamin-like protein,DLP1,Dymple,Dynamin-1-like protein,HdynIV,Dnm1p/Vps1p-like protein,DRP1,DNM1L,Dynamin-like protein 4

Purification

Purified by antigen affinity column.

Accession

O00429

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Ginsenoside Compound K Mitigates Mitochondrial Fission Through Bile Acid Receptors/YAP Signaling to Counteract Podocyte Injury in Lupus Nephritis., PMID:40528637

Yellow fever virus infection alters mitochondrial network dynamics and trigger IFN-I response via TLR2 pathway., PMID:40300356

Enhancing anti-CD3 mAb-mediated diabetes remission in autoimmune diabetes through regulation of dynamin-related protein 1(Drp1)-mediated mitochondrial dynamics in exhausted CD8+T-cell subpopulations., PMID:40165248

[Mechanism of the pretreatment with electroacupuncture of "biaoben acupoint combination" for regulating cardiomyocyte mitochondrial fission in the rats of myocardial ischemia-reperfusion injury]., PMID:40097217

MEHP induced mitochondrial damage by promoting ROS production in CIK cells, leading to apoptosis, autophagy, cell cycle arrest., PMID:39586385

MSCs-derived HGF alleviates senescence by inhibiting unopposed mitochondrial fusion-based elongation in post-acute kidney injury., PMID:39563422

Nanobodies as novel tools to monitor the mitochondrial fission factor Drp1., PMID:38816213

APOE and Alzheimer's disease: Pathologic clues from transgenic Drosophila melanogaster., PMID:38537387

NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia., PMID:38480688

Photobiomodulation therapy with light-emitting diode in stimulating adipose tissue mitochondria., PMID:37851070

Dynamin-like Protein 1 (DNML1) as a Molecular Target for Antibody-Based Immunotherapy to Treat Glaucoma., PMID:36362420

Panax notoginseng saponin R1 attenuates allergic rhinitis through AMPK/Drp1 mediated mitochondrial fission., PMID:35623408

Analysis of hemisphere-dependent effects of unilateral intrastriatal injection of α-synuclein pre-formed fibrils on mitochondrial protein levels, dynamics, and function., PMID:35606853

Transcriptomic and ultrastructural evidence indicate that anti-HMGB1 antibodies rescue organic dust-induced mitochondrial dysfunction., PMID:35244775

Necroptosis Inhibition by Hydrogen Sulfide Alleviated Hypoxia-Induced Cardiac Fibroblasts Proliferation via Sirtuin 3., PMID:34769322

Activation of CD137 signaling promotes macrophage apoptosis dependent on p38 MAPK pathway-mediated mitochondrial fission., PMID:33971320

MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell Exocytosis., PMID:33941653

Mitochondrial Dynamics and VMP1-Related Selective Mitophagy in Experimental Acute Pancreatitis., PMID:33816487

Ganglioside GD3 regulates dendritic growth in newborn neurons in adult mouse hippocampus via modulation of mitochondrial dynamics., PMID:32743804

Imaging Dynamin-Related Protein 1 (Drp1)-Mediated Mitochondrial Fission in Living Cells., PMID:32529374

Quantifying Drp1-Mediated Mitochondrial Fission by Immunostaining in Fixed Cells., PMID:32529373

Apolipoprotein E negatively regulates murine allergic airway inflammation via suppressing the activation of NLRP3 inflammasome and oxidative stress., PMID:32062073

Two distinct actin filament populations have effects on mitochondria, with differences in stimuli and assembly factors., PMID:31413070

Hyperbaric oxygen promotes mitophagy by activating CaMKKβ/AMPK signal pathway in rats of neuropathic pain., PMID:31382832

Emerging views of mitophagy in immunity and autoimmune diseases., PMID:30951392

Expression of mitochondrial dynamics markers during melanoma progression: Comparative study of head and neck cutaneous and mucosal melanomas., PMID:30916813

Calcineurin/P38MAPK/HSP27-dependent pathways are involved in the attenuation of postischemic mitochondrial injury afforded by sodium bicarbonate co-transporter (NBCe1) inhibition., PMID:30615862

Effect of Qiangji Jianli decoction on mitochondrial respiratory chain activity and expression of mitochondrial fusion and fission proteins in myasthenia gravis rats., PMID:29872094

Novel Therapeutic Targets in Cutaneous Squamous Cell Carcinoma., PMID:29629337

BI1 is associated with microvascular protection in cardiac ischemia reperfusion injury via repressing Syk-Nox2-Drp1-mitochondrial fission pathways., PMID:29623489

Evolution of cytokinesis-related protein localization during the emergence of multicellularity in volvocine green algae., PMID:29212441

Overcoming Resistance to Cetuximab with Honokiol, A Small-Molecule Polyphenol., PMID:29054984

ALS-associated mutation SOD1G93A leads to abnormal mitochondrial dynamics in osteocytes., PMID:29030231

Advanced glycation end products influence mitochondrial fusion-fission dynamics through RAGE in human aortic endothelial cells., PMID:31966653

Ang-(1-7) inhibited mitochondrial fission in high-glucose-induced podocytes by upregulation of miR-30a and downregulation of Drp1 and p53., PMID:27789249

Mitochondrial Dysfunction in the Liver and Antiphospholipid Antibody Production Precede Disease Onset and Respond to Rapamycin in Lupus-Prone Mice., PMID:27332042

Relocation of p25α/tubulin polymerization promoting protein from the nucleus to the perinuclear cytoplasm in the oligodendroglia of sporadic and COQ2 mutant multiple system atrophy., PMID:25208467

Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission., PMID:24515348

The neuroprotective effect of carnosine (β-alanyl-L-histidine) on retinal ganglion cell following ischemia-reperfusion injury., PMID:24206188

Atypical mitochondrial fission upon bacterial infection., PMID:24043775

HRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE., PMID:23897774

The mitochondrial elongation factors MIEF1 and MIEF2 exert partially distinct functions in mitochondrial dynamics., PMID:23880462

Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c., PMID:23821750

Declines in Drp1 and parkin expression underlie DNA damage-induced changes in mitochondrial length and neuronal death., PMID:23345212

Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress., PMID:23015593

Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q(10) treatment., PMID:22529290

Dynamic changes of mitochondrial fission proteins after transient cerebral ischemia in mice., PMID:22498177

Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction., PMID:22428580

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage., PMID:22367970

Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission., PMID:21701560

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