Catalog No.
FHJ26310
Species reactivity
Human
Host species
Mouse
Isotype
IgG1, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
CD85 antigen-like family member K, LIR-5, Leukocyte immunoglobulin-like receptor 5, ILT3, ILT-3, Immunoglobulin-like transcript 3, LILRB4, CD85k, Leukocyte immunoglobulin-like receptor subfamily B member 4, Monocyte inhibitory receptor HM18, LIR5
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q8NHJ6
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
128-3
A Switch Protein Adapter for Anti-LILRB4 CAR-T Cells., PMID:39663681
LILRB4 regulates multiple myeloma development through STAT3-PFKFB1 pathway., PMID:39025844
Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model., PMID:38569016
LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6 pathway during Toxoplasma gondii infection., PMID:37461040
Fibronectin on target cells attenuates natural cytotoxicity of NK cells via myeloid immune checkpoint ILT3/LILRB4/gp49B., PMID:37083755
BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike protein., PMID:35967447
The Fibronectin-ILT3 Interaction Functions as a Stromal Checkpoint that Suppresses Myeloid Cells., PMID:34426457
Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice., PMID:34089617
LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy., PMID:33974041
ILT3 (LILRB4) Promotes the Immunosuppressive Function of Tumor-Educated Human Monocytic Myeloid-Derived Suppressor Cells., PMID:33372059
LILRB4-targeting Antibody-Drug Conjugates for the Treatment of Acute Myeloid Leukemia., PMID:32879051
Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development., PMID:31213474
Augmented ILT3/LILRB4 Expression of Peripheral Blood Antibody Secreting Cells in the Acute Phase of Kawasaki Disease., PMID:30882741
LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration., PMID:30333625
ILT3.Fc-CD166 Interaction Induces Inactivation of p70 S6 Kinase and Inhibits Tumor Cell Growth., PMID:29263213
Ectopic ILT3 controls BCR-dependent activation of Akt in B-cell chronic lymphocytic leukemia., PMID:28931525
Tolerogenic immunoreceptor ILT3/LILRB4 paradoxically marks pathogenic auto-antibody-producing plasmablasts and plasma cells in non-treated SLE., PMID:27742834
Leukocyte immunoglobulin-like receptor B4 regulates key signalling molecules involved in FcγRI-mediated clathrin-dependent endocytosis and phagocytosis., PMID:27725776
Tregitope: Immunomodulation powerhouse., PMID:25454619
ILT3.Fc inhibits the production of exosomes containing inflammatory microRNA in supernatants of alloactivated T cells., PMID:24862932
Allospecific CD8 T suppressor cells induced by multiple MLC stimulation or priming in the presence of ILT3.Fc have similar gene expression profiles., PMID:24220571
Induction of antigen-specific human T suppressor cells by membrane and soluble ILT3., PMID:23018130
Human myeloid dendritic cells are refractory to tryptophan metabolites., PMID:21699942
BCL6 is required for differentiation of Ig-like transcript 3-Fc-induced CD8+ T suppressor cells., PMID:20935202
Immunoglobulin-like transcript 3, an inhibitor of T cell activation, is reduced on blood monocytes during multiple sclerosis relapses and is induced by interferon beta-1b., PMID:20007427
Suppression of xenogeneic graft-versus-host disease by treatment with immunoglobulin-like transcript 3-Fc., PMID:19501624
Changes in the expression of the immunoglobulin-like transcript 3 (ILT3) and ILT4 receptors in renal allograft recipients: effect of donor and recipient aging., PMID:19010139
Immunoglobulin-like transcript 3-Fc suppresses T-cell responses to allogeneic human islet transplants in hu-NOD/SCID mice., PMID:18420485
Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells., PMID:17998301
Pancreas cancer and the role of soluble immunoglobulin-like transcript 3 (ILT3)., PMID:17993722
IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cells., PMID:17163451
Recombinant Ig-like transcript 3-Fc modulates T cell responses via induction of Th anergy and differentiation of CD8+ T suppressor cells., PMID:16493035
Expression, purification, and refolding of the myeloid inhibitory receptor leukocyte immunoglobulin-like receptor-5 for structural and ligand identification studies., PMID:16406677
Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+Foxp3+ regulatory T cells by 1,25-dihydroxyvitamin D3., PMID:16030186
Induction of tolerance by Porphyromonas gingivalis on APCS: a mechanism implicated in periodontal infection., PMID:15111638
A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing., PMID:9151699
For research use only. Not for human or drug use.
