Catalog No.
FHC13110
Species reactivity
Human
Host species
Human
Isotype
IgG1
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
ELISA, FCM, IHC, WB
Target
Complement receptor C3 subunit beta, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Integrin beta-2, MFI7, CD18, ITGB2, RHC13101
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P05107
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0815
Note
For research use only.
Monocytes augment inflammatory responses in human aortic valve interstitial cells via β2-integrin/ICAM-1-mediated signaling., PMID:35411432
Using digital RNA counting to establish flow cytometry diagnostic criteria for subtypes of CD34+ canine acute leukaemia., PMID:35491468
Humanized β2 Integrin-Expressing Hoxb8 Cells Serve as Model to Study Integrin Activation., PMID:35563841
A humanized β2 integrin knockin mouse reveals localized intra- and extravascular neutrophil integrin activation in vivo., PMID:35649374
CD18 Mediates Neutrophil Imperviousness to the Aggregatibacter actinomycetemcomitans JP2 Clone in Molar-Incisor Pattern Periodontitis., PMID:35663998
Cancer cells resist antibody-mediated destruction by neutrophils through activation of the exocyst complex., PMID:35728876
Flow Cytometric Analysis of Leukocyte Populations in the Lung Tissue of Dromedary Camels., PMID:35737339
Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin., PMID:35977491
β2-Integrin Adhesive Bond Tension under Shear Stress Modulates Cytosolic Calcium Flux and Neutrophil Inflammatory Response., PMID:36139397
B-cell receptor associated protein 31 deficiency decreases the expression of adhesion molecule CD11b/CD18 and PSGL-1 in neutrophils to ameliorate acute lung injury., PMID:36210579
Characterization of microglia/macrophage phenotypes in the spinal cord following intervertebral disc herniation., PMID:36262531
High-Dimensional Cytometry Dissects Immunological Fingerprints of Idiopathic Inflammatory Myopathies., PMID:36291195
Undifferentiated Wing Sarcoma in a Peach-Faced Lovebird (Agapornis roseicollis)., PMID:36335863
Integrin CD11b Contributes to Hypertension and Vascular Dysfunction Through Mediating Macrophage Adhesion and Migration., PMID:36377602
Immunosuppressive Effects of Annona muricata L. Leaf Extract on Cellular and Humoral Immune Responses in Male Wistar Rats., PMID:36545731
In-depth immunophenotyping reveals significant alteration of lymphocytes in buffalo with brucellosis., PMID:36602043
Neutrophil function following treatment of psoriatic arthritis patients with secukinumab: altered cytokine signalling but no impairment of host defence., PMID:36617171
Myo/Nog Cells Give Rise to Myofibroblasts During Epiretinal Membrane Formation in a Mouse Model of Proliferative Vitreoretinopathy., PMID:36723927
The CIS association of CD47 with integrin Mac-1 regulates macrophage responses by stabilizing the extended integrin conformation., PMID:36796515
Phenotyping and Genotyping of HNA: Prevalence, Risk of Alloimmunization, and HNA Incompatibilities in Indians., PMID:36818775
CD11b mediates hypertensive cardiac remodeling by regulating macrophage infiltration and polarization., PMID:36822392
Phagocytosis via complement receptor 3 enables microbes to evade killing by neutrophils., PMID:36882066
Allosteric targeting resolves limitations of earlier LFA-1 directed modalities., PMID:36921634
Modulating CD40 and integrin signaling in the proinflammatory nexus using a 15-amino-acid peptide, KGYY15., PMID:36944397
Mechano-Redox Control of Mac-1 De-Adhesion by PDI Promotes Directional Movement Under Flow., PMID:37021588
Regulation of coagulation activation in newly diagnosed AML by the heme enzyme myeloperoxidase., PMID:37473552
Polymorphonuclear phenotypical expression of CD18, at baseline and after in vitro activation, in several clinical disorders: Revision of our case series., PMID:37482987
Neutrophil attachment via Mac-1 (αMβ2; CD11b/CD18; CR3) integrins induces PAD4 deimination of profilin and histone H3., PMID:37778386
Analysis of cells of epithelial, connective tissue and immune differentiation in HPV-positive-, HPV-negative oropharyngeal carcinoma and normal oropharyngeal tissue by immunofluorescence multiplex image cytometry: a preliminary report., PMID:38012597
SIGLEC-5/14 Inhibits CD11b/CD18 Integrin Activation and Neutrophil-Mediated Tumor Cell Cytotoxicity., PMID:38138970
A Flow Cytometry-Based High-Throughput Technique for Screening Integrin-Inhibitory Drugs., PMID:38372326
The extracellular cyclophilin A-integrin β2 complex as a therapeutic target of viral pneumonia., PMID:38454605
SKAP2 acts downstream of CD11b/CD18 and regulates neutrophil effector function., PMID:38487529
The monocyte cell surface is a unique site of autoantigen generation in rheumatoid arthritis., PMID:38630712
Melan-A immunolabeling in canine extramedullary plasmacytomas., PMID:38642035
Flow cytometric analysis of immune cell populations in the bronchial and mesenteric lymph nodes of the dromedary camel., PMID:38746932
Deletion of Talin1 in Myeloid Cells Facilitates Atherosclerosis in Mice., PMID:38899470
CD47-SIRPα Blockade Sensitizes Head and Neck Squamous Cell Carcinoma to Cetuximab by Enhancing Macrophage Adhesion to Cancer Cells., PMID:38959336
Sarcomas of synovial origin in dogs: An updated review., PMID:39068516
Flow cytometric-based detection of CD80 is a useful diagnostic marker of acute myeloid leukemia in dogs., PMID:39224452
Targeting Human Pancreatic Cancer with a Fluorophore-Conjugated Mucin 4 (MUC4) Antibody: Initial Characterization in Orthotopic Cell Line Mouse Models., PMID:39458160
Mechanisms of Mt.b Ag85B-Fc fusion protein against allergic asthma in mice by intranasal immunization., PMID:39549815
Humanized anti-CD11d monoclonal antibodies suitable for basic research and therapeutic applications., PMID:39839909
Triple knockdown of CD11a, CD49d, and PSGL1 in T cells reduces CAR-T cell toxicity but preserves activity against solid tumors in mice., PMID:39841806
Dual in vivo T cell depleted haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide and anti-thymocyte globulin as a third salvage transplant for leukocyte adhesion deficiency with graft failure: a case report., PMID:39845947
Extracellular vesicle surface engineering with integrins (ITGAL & ITGB2) to specifically target ICAM-1-expressing endothelial cells., PMID:39885580
ICAM-1/CD18-mediated sequestration of parasitized phagocytes in cortical capillaries promotes neuronal colonization by Toxoplasma gondii., PMID:40229286
MOSPD2 regulates the activation state of αLβ2 integrin to control monocyte migration: applicability for treatment of chronic inflammatory diseases., PMID:40312574
Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells., PMID:40381622
PSGL-1 is a phagocytosis checkpoint that enables tumor escape from macrophage clearance., PMID:40512837
For research use only. Not for human or drug use.
