Catalog No.
FHF68810
Species reactivity
Human
Host species
Mouse
Isotype
IgG1, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
TACE, Snake venom-like protease, ADAM17, CD156b, CSVP, ADAM 17, Disintegrin and metalloproteinase domain-containing protein 17, TNF-alpha convertase, TNF-alpha-converting enzyme
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P78536
Applications
FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
1022C3
Structural insights into the activation and inhibition of the ADAM17-iRhom2 complex., PMID:40512800
Antibodies targeting ADAM17 reverse neurite outgrowth inhibition by myelin-associated inhibitors., PMID:40132887
Role of ADAM10/17-Mediated Cleavage of LAG3 in the Impairment of Immunosuppression in Psoriasis., PMID:39571889
Fully human monoclonal antibody targeting the cysteine-rich substrate-interacting region of ADAM17 on cancer cells., PMID:39461016
Enhanced IL-15-mediated NK cell activation and proliferation by an ADAM17 function-blocking antibody involves CD16A, CD137, and accessory cells., PMID:39053944
The inhibition of ADAM17 in cord blood stem cell-derived CD16+ NK cells to enhance their cytotoxicity against acute lymphoblastic leukemia cells., PMID:38429146
Mesenchymal Transglutaminase 2 Activates Epithelial ADAM17: Link to G-Protein-Coupled Receptor 56 (ADGRG1) Signalling., PMID:38397010
Investigation of CD56, ADAM17 and FGF21 Expressions in the Placentas of Preeclampsia Cases., PMID:37374349
The estrogen/miR-338-3p/ADAM17 axis enhances the viability of breast cancer cells via suppressing NK cell's function., PMID:37052432
Periostin derived from cancer-associated fibroblasts promotes esophageal squamous cell carcinoma progression via ADAM17 activation., PMID:36813090
Single nucleotide polymorphisms in ADAM17, IL23R and SLCO1C1 genes protect against infliximab failure in adults with Crohn's disease., PMID:36621146
ADAM10 mediates shedding of carbonic anhydrase IX ectodomain non‑redundantly to ADAM17., PMID:36524367
Immunomodulatory role of metalloproteinase ADAM17 in tumor development., PMID:36466812
Role of ADAM10 and ADAM17 in the Regulation of Keratinocyte Adhesion in Pemphigus Vulgaris., PMID:35844545
An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model., PMID:35757773
Activation of ADAM17 by IL-15 Limits Human NK Cell Proliferation., PMID:34367174
Variable Clinical Manifestations of COVID-19: Viral and Human Genomes Talk., PMID:33463113
Ectodomain shedding by ADAM17 (a disintegrin and metalloproteinase 17) in canine neutrophils., PMID:33264689
Lysophosphatidic acid induces tumor necrosis factor-alpha to regulate a pro-inflammatory cytokine network in ovarian cancer., PMID:32851734
Recent developments and strategies for the discovery of TACE inhibitors., PMID:32281878
ADAM proteases: Emerging role and targeting of the non-catalytic domains., PMID:31593799
Delivery of Liver-Specific miRNA-122 Using a Targeted Macromolecular Prodrug toward Synergistic Therapy for Hepatocellular Carcinoma., PMID:30802029
Role of ADAM17 as a regulatory checkpoint of CD16A in NK cells and as a potential target for cancer immunotherapy., PMID:30786043
Effects of Soluble Tumor Necrosis Factor (TNF) on Antibody-Dependent Cellular Cytotoxicity of Therapeutic anti-TNF-α Antibody., PMID:30569777
[ADAM17 knockdown increases sensitivity of SW480 cells to cetuximad]., PMID:30514687
Role of MEL-18 Amplification in Anti-HER2 Therapy of Breast Cancer., PMID:30265336
Anti-ADAM17 monoclonal antibody MEDI3622 increases IFNγ production by human NK cells in the presence of antibody-bound tumor cells., PMID:29978334
Effects of ADAM10 and ADAM17 Inhibitors on Natural Killer Cell Expansion and Antibody-dependent Cellular Cytotoxicity Against Breast Cancer Cells In Vitro., PMID:28982863
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function., PMID:28855300
Anti-tumor effects of a 'human & mouse cross-reactive' anti-ADAM17 antibody in a pancreatic cancer model in vivo., PMID:28554668
Nivolumab effectively inhibit platinum-resistant ovarian cancer cells via induction of cell apoptosis and inhibition of ADAM17 expression., PMID:28387913
IL-6 trans-signaling is another pathway to upregulate Osteopontin., PMID:27863335
Molecular basis for the mechanism of action of an anti-TACE antibody., PMID:27610476
Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes., PMID:27599715
The role of RNase 7 in innate cutaneous defense against Pseudomonas aeruginosa., PMID:27513608
Targeting ADAM17 Sheddase Activity in Cancer., PMID:27469341
Apoptosis-induced ectodomain shedding of hypoxia-regulated carbonic anhydrase IX from tumor cells: a double-edged response to chemotherapy., PMID:26993100
Areca nut components stimulate ADAM17, IL-1α, PGE2 and 8-isoprostane production in oral keratinocyte: role of reactive oxygen species, EGF and JAK signaling., PMID:26919242
The Inflammasome and the Epidermal Growth Factor Receptor (EGFR) Are Involved in the Staphylococcus aureus-Mediated Induction of IL-1alpha and IL-1beta in Human Keratinocytes., PMID:26808616
Proteolytically active ADAM10 and ADAM17 carried on membrane microvesicles in human abdominal aortic aneurysms., PMID:26422658
Targeting ADAM-17 with an inhibitory monoclonal antibody has antitumour effects in triple-negative breast cancer cells., PMID:26010411
A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways., PMID:25948294
Increased B Cell ADAM10 in Allergic Patients and Th2 Prone Mice., PMID:25933166
Identification of an ADAM17 cleavage region in human CD16 (FcγRIII) and the engineering of a non-cleavable version of the receptor in NK cells., PMID:25816339
Circulating ADAM17 Level Reflects Disease Activity in Proteinase-3 ANCA-Associated Vasculitis., PMID:25788529
Regulation of CXCR2 expression and function by a disintegrin and metalloprotease-17 (ADAM17)., PMID:25412626
Targeting CD13 (aminopeptidase-N) in turn downregulates ADAM17 by internalization in acute myeloid leukaemia cells., PMID:25246708
Exosomes from human immunodeficiency virus type 1 (HIV-1)-infected cells license quiescent CD4+ T lymphocytes to replicate HIV-1 through a Nef- and ADAM17-dependent mechanism., PMID:25056899
Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation., PMID:25013379
A novel marker ADAM17 for clear cell renal cell carcinomas: implication for patients' prognosis., PMID:24996774
For research use only. Not for human or drug use.
