Catalog No.
RVV09301
Expression system
Mammalian Cells
Species reactivity
Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Target
p21, Mature core protein, Genome polyprotein
Concentration
1.55 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P29846
Applications
ELISA, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
19D9D6
Immunosenescence in atherosclerosis: A role for chronic viral infections. PMID: 36059478
Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) : Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015. PMID: 25710583
The Differential Immunohistochemical Expression of p53, c-Jun, c-Myc, and p21 Between HCV-related Hepatocellular Carcinoma With and Without Cirrhosis. PMID: 30704781
Serum lincRNA-p21 expression in primary liver diseases and liver metastatic diseases. PMID: 15259070
HCV NS5A abrogates p53 protein function by interfering with p53-DNA binding. PMID: 20164022
p21/Wafl/Cipl cellular expression in chronic long-lasting hepatitis C: correlation with HCV proteins (C, NS3, NS5A), other cell-cycle related proteins and selected clinical data. PMID: 23888939
Epigenetic mechanism involved in the HBV/HCV-related hepatocellular carcinoma tumorigenesis. PMID: 20815982
[HCV DF protein inhibits expression of p16 and p21 in HepG₂ cells]. PMID: 11762751
Inhibition of p21/Waf1/Cip1/Sdi1 expression by hepatitis C virus core protein. PMID: 23577194
Hepatitis C virus core protein down-regulates p21(Waf1/Cip1) and inhibits curcumin-induced apoptosis through microRNA-345 targeting in human hepatoma cells. PMID: 23809295
Impact of Hepatitis C Virus (HCV) infection on biomolecular markers influencing the pathogenesis of bladder cancer. PMID: 14511646
Structured HCV nucleocapsids composed of P21 core protein assemble primary in the nucleus of Pichia pastoris yeast. PMID: 10883667
Reduced p21(WAF1/CIP1) protein expression is predominantly related to altered p53 in hepatocellular carcinomas. PMID: 29380693
Hepatitis C Virus Mediated Metastasis in Hepatocellular Carcinoma as a Therapeutic Target for Cancer Management. PMID: 12101418
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis. PMID: 11514734
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3. PMID: 19152410
Cell cycle perturbation in the hepatocytes of HCV core transgenic mice following common bile duct ligation is associated with enhanced p21 expression. PMID: 25656993
Oxidative challenge enhances REGγ-proteasome-dependent protein degradation. PMID: 9621068
The native form and maturation process of hepatitis C virus core protein. PMID: 12217602
Infection of HepG2 cells with recombinant adenovirus encoding the HCV core protein induces p21(WAF1) down-regulation -- effect of transforming growth factor beta. PMID: 11819378
Effect of HCV infection on expression of several cancer-associated gene products in HCC. PMID: 11551651
The repressive activity of hepatitis C virus core protein on the transcription of p21(waf1) is regulated by protein kinase A-mediated phosphorylation. PMID: 17255101
p21-activated kinase 1 is activated through the mammalian target of rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in human hepatoma cells. PMID: 12906103
Hepatitis C virus core protein selectively inhibits synthesis and accumulation of p21/Waf1 and certain nuclear proteins. PMID: 12185267
Hepatitis C virus core protein represses the p21 promoter through inhibition of a TGF-beta pathway. PMID: 21160954
Differential expression of cell cycle regulators in HCV-infection and related hepatocellular carcinoma. PMID: 12056798
Subcellular localization of HCV core protein regulates its ability for p53 activation and p21 suppression. PMID: 11997040
Cooperative repression of cyclin-dependent kinase inhibitor p21 gene expression by hepatitis B virus X protein and hepatitis C virus core protein. PMID: 23825904
Decreased apoptosis in advanced-stage/high-grade hepatocellular carcinoma complicating chronic hepatitis C is mediated through the downregulation of p21 ras. PMID: 29404509
Newly discovered hepatitis C virus minicores circulate in human blood. PMID: 11152513
Hepatitis C virus NS5A physically associates with p53 and regulates p21/waf1 gene expression in a p53-dependent manner. PMID: 9524287
Hepatitis C virus core protein represses p21WAF1/Cip1/Sid1 promoter activity. PMID: 14745598
HCV core, NS3, NS5A and NS5B proteins modulate cell proliferation independently from p53 expression in hepatocarcinoma cell lines. PMID: 12055678
High expression of p21WAF1/CIP1 is correlated with human hepatocellular carcinoma in patients with hepatitis C virus-associated chronic liver diseases. PMID: 27930338
Pegylated IFN-α suppresses hepatitis C virus by promoting the DAPK-mTOR pathway. PMID: 8116235
Comparative studies of the core gene products of two different hepatitis C virus isolates: two alternative forms determined by a single amino acid substitution. PMID: 28329914
Ginsenoside Rg3 restores hepatitis C virus-induced aberrant mitochondrial dynamics and inhibits virus propagation. PMID: 7491770
Differential subcellular localization of hepatitis C virus core gene products. PMID: 16246194
Hepatitis C virus-NS3P in relation to p53, p21waf, mdm2, p21-ras and c-erbB2 in hepatocarcinogenesis. PMID: 23638118
Hepatitis C virus NS2 protein inhibits DNA damage pathway by sequestering p53 to the cytoplasm. PMID: 25096815
Alternative endocytosis pathway for productive entry of hepatitis C virus. PMID: 17894800
Role of hepatitis C virus proteins (C, NS3, NS5A) in hepatic oncogenesis. PMID: 23624687
Crystal structure of a hydrophobic immunodominant antigenic site on hepatitis C virus core protein complexed to monoclonal antibody 19D9D6. PMID: 12574359
Potential of mean force of the hepatitis C virus core protein-monoclonal 19D9D6 antibody interaction. PMID: 19819062
Different crystal packing in Fab-protein L semi-disordered peptide complex. PMID: 15930632
HCV core immunodominant region analysis using mouse monoclonal antibodies and human sera: characterization of major epitopes useful for antigen detection. PMID: 9829633
Correlation of TP53 mutations with HCV positivity in hepatocarcinogenesis: identification of a novel TP53 microindel in hepatocellular carcinoma with HCV infection. PMID: 12065893
The nonstructural NS5A protein of hepatitis C virus: an expanding, multifunctional role in enhancing hepatitis C virus pathogenesis. PMID: 26258805
MicroRNA regulation of viral immunity, latency, and carcinogenesis of selected tumor viruses and HIV. PMID: 29444947
Hepatitis C Virus core+1/ARF Protein Modulates the Cyclin D1/pRb Pathway and Promotes Carcinogenesis. PMID: 12823590
Dual effects of hepatitis C virus Core protein on the transcription of cyclin-dependent kinase inhibitor p21 gene. PMID: 15334054
Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activation. PMID: 15469695
Suppression of ceramide-induced cell death by hepatitis C virus core protein. PMID: 16488393
For research use only. Not for human or drug use.
