Catalog No.
EHD75201
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Ala413
Predicted molecular weight
51.63 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P27797
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Calreticulin, ERp60, CRTC, Calregulin, grp60, HACBP, Endoplasmic reticulum resident protein 60, CALR, CRP55
Note
For research use only.
High Expression of Calreticulin Affected the Tumor Microenvironment and Correlated With Worse Prognosis in Patients With Triple-Negative Breast Cancer., PMID:40123257
Dual blockade of GSTK1 and CD47 improves macrophage-mediated phagocytosis on cancer cells., PMID:40147800
A CXCR4-targeted immunomodulatory nanomedicine for photodynamic amplified immune checkpoint blockade therapy against breast cancer., PMID:40154764
Complete assignment of 1H and 13C NMR signals of monoglucosylated high-mannose type glycan attached to asparagine., PMID:40168794
PD-L1 targeted antibody-polymer-Epirubicin conjugate prolongs survival in a preclinical murine model of advanced ovarian cancer., PMID:40185333
Preliminary In silico Analysis of Echinococcus granulosus Calreticulin for Enhanced Vaccine Design against Cystic Echinococcosis., PMID:40195705
Regulation of immunogenic cell death and potential applications in cancer therapy., PMID:40207233
Smad7 is a negative regulator of immunogenic cell death in colorectal cancer., PMID:40213961
LGALS3BP antibody-drug conjugate enhances tumor-infiltrating lymphocytes and synergizes with immunotherapy to restrain neuroblastoma growth., PMID:40217513
An oncolytic adenovirus targeting SLAMF7 demonstrates anti-myeloma efficacy., PMID:40247106
Functional characterization of calreticulin in the antiviral response of Litopenaeus vannamei against white spot syndrome virus., PMID:40250553
Nanoarchitectured hyaluronic acid-decorated hierarchical drug-like assemblies as synergistic immune modulators against breast carcinoma., PMID:40250652
Thrombospondin-1 induces immunogenic cell death in human mucoepidermoid carcinoma MC-3 cells via the PERK/eIF2α signaling pathway: potential implications for tumor immunotherapy., PMID:40253314
In vitro evaluation of the immunogenic potential of gramicidin S and its photocontrolled analogues., PMID:40270993
Synergistic Induction of Immunogenic Cell Death by Biomineralized Manganese and Bisphosphonates Enhances Anti-PD-L1 Therapy in Triple-Negative Breast Cancer., PMID:40276640
A BioID-based approach uncovers the interactome of hexose-6-phosphate dehydrogenase in breast cancer cells and identifies anterior gradient protein 2 as an interacting partner., PMID:40281598
Molecular predictors of venous and arterial thrombotic events in patients with myelofibrosis., PMID:40287867
Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing NRAS-Mutant Melanoma to MEK Inhibitors., PMID:40287947
The relationship between serum levels of GRP78, GRP94, calnexin, and calreticulin and prognosis in patients with lung cancer., PMID:40289385
Phagocytosis-Activating Nanocomplex Orchestrates Macrophage-Mediated Cancer Immunotherapy., PMID:40289887
Doxycycline-Induced Apoptosis in Brucella suis S2-Infected HMC3 Cells via Calreticulin Suppression and Activation of the IRE1/Caspase-3 Signaling Pathway., PMID:40290405
Effects of anlotinib hydrochloride on the expression of immunogenic cell death-related molecules in Cal27 tongue cancer cells., PMID:40299226
Cell-Based Small-Molecule Screening Identifying Proteostasis Regulators Enhancing Factor VIII Missense Mutant Secretion., PMID:40305178
Vaccinomics-driven selection and validation of protective salivary antigens from the argasid tick Ornithodoros moubata., PMID:40306020
DNA methylation in primary myelofibrosis is partly associated with driver mutations and distinct from other myeloid malignancies., PMID:40319310
AlphaFold2 SLiM screen for LC3-LIR interactions in autophagy., PMID:40320752
Engineered Bacterial Biohybrid-Mediated CD47-SIRPα Blockade and HSP90 Inhibition for Enhanced Immuno-Photothermal Therapy., PMID:40331355
Echinococcus multilocularis Calreticulin Inhibits Lectin Pathway of Complement Activation by Directly Binding to Mannose-Binding Lectin., PMID:40333123
Combined exposure to atrazine and phoxim exacerbated the alterations of enzyme activity and abnormal gene expression in earthworms (Eisenia fetida)., PMID:40345462
Discovery of Cu(II)-Dipyridophenazine Complex for Synergistic Cuproptosis/Chemodynamic Therapy via Disrupting the Tricarboxylic Acid (TCA) Cycle in Metastatic TNBC., PMID:40348584
Differential regulation of mTORC2 signalling by type I and type II calreticulin (CALR) driver mutations of myeloproliferative neoplasm., PMID:40355863
BiP, GRP94, calreticulin and calnexin contribute to development of the notochord in medaka fish., PMID:40368802
A fermented Mistletoe (Viscum album L.) extract elicits markers characteristic for immunogenic cell death driven by endoplasmic reticulum stress in vitro., PMID:40369535
Immunomodulatory effects of intratumoral cowpea mosaic virus and calreticulin nanoparticles in canine tumors: early results., PMID:40386779
Partial mitochondrial involvement in the antiproliferative and immunostimulatory effects of PT-112., PMID:40386940
Macrophages release neuraminidase and cleaved calreticulin for programmed cell removal., PMID:40397678
Type 2 calreticulin mutations activate ATF6 to promote BCL-xL-mediated survival in myeloproliferative neoplasms., PMID:40403318
Intrinsic Disorder and Phase Separation Coordinate Exocytosis, Motility, and Chromatin Remodeling in the Human Acrosomal Proteome., PMID:40407495
Targeting CALR reduces energy metabolism of esophageal cancer cells and inhibits tumor‑associated fibroblast infiltration., PMID:40417915
NOTCH1 inhibition enhances immunogenicity and sensitizes triple-negative breast cancer to immune checkpoint inhibitors., PMID:40420289
Comparative Transcriptome Analysis Elucidates the Desiccation Stress Adaptation in Sargassum muticum., PMID:40428409
An Endoplasmic Reticulum Stress-Specific Nanoinducer Selectively Evokes Type-II Immunogenic Cell Death for Pyroptotic Cancer Immunotherapy., PMID:40434207
A novel calreticulin of Psoroptes ovis regulated keratinocyte function resulting in host skin barrier dysfunction: implications for involvement in the pathogenesis of psoroptic mange., PMID:40448127
Patritumab deruxtecan induces immunogenic cell death., PMID:40458967
Generation of a Synthetic Single Domain Antibody Library for Radiopharmaceutical Ligand Discovery., PMID:40463173
Design, Synthesis, and Evaluation of Pyrazolopyridine Derivatives as Novel Calreticulin (CALR) Ligands That Inhibit Triple-Negative Breast Cancer (TNBC) via Inducing Calcium Overloading., PMID:40464282
Enhancing antitumor immunity via ROS-ERS and pyroptosis-induced immunogenic cell death in multiple myeloma., PMID:40473272
A rare CALR exon 9 mutation p.E379Vfs*53 in AYA generation exhibits gain-of-function nature and can induce essential thrombocythemia; a case report., PMID:40474352
Dexmedetomidine induces immunogenic cancer cell death and sensitizes tumors to PD-1 blockade., PMID:40480656
Studying Immunogenic Cell Death in Human Colorectal Cancer Organoids., PMID:40502372
For research use only. Not for human or drug use.
