Catalog No.
DHG17603
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Humanized
Isotype
IgG4-Kappa
Clonality
Monoclonal
Target
Leukocyte surface antigen CD47, CD47, Antigenic surface determinant protein OA3, IAP, Integrin-associated protein, Protein MER6, MER6
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q08722
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
CD47, TJ-011133, TJC-4, CAS: 2377483-71-9
Clone ID
Lemzoparlimab
CD47 does not mediate amyloid-beta(1-42) protofibril-stimulated microglial cytokine release. PMID: 25451248
Co-engaging CD47 and CD19 with a bispecific antibody abrogates B-cell receptor/CD19 association leading to impaired B-cell proliferation. PMID: 30569825
Targeting CD47 and Autophagy Elicited Enhanced Antitumor Effects in Non-Small Cell Lung Cancer. PMID: 28351890
Donor CD47 controls T cell alloresponses and is required for tolerance induction following hepatocyte allotransplantation. PMID: 27230788
CD47 signaling regulates the immunosuppressive activity of VEGF in T cells. PMID: 25200950
Role of Erythrocyte CD47 in Intracerebral Hematoma Clearance. PMID: 26732568
CD47(high) expression on CD4 effectors identifies functional long-lived memory T cell progenitors. PMID: 22461697
Blocking CD47 shrinks pancreatic tumors. PMID: 25092731
RRx-001, a downregulator of the CD47- SIRPalpha checkpoint pathway, does not cause anemia or thrombocytopenia. PMID: 33432831
Single-cell RNA sequencing study of retinal immune regulators identified CD47 and CD59a expression in photoreceptors-Implications in subretinal immune regulation. PMID: 32166783
Combination of anthracyclines and anti-CD47 therapy inhibit invasive breast cancer growth while preventing cardiac toxicity by regulation of autophagy. PMID: 30056566
Macrophage engulfment of a cell or nanoparticle is regulated by unavoidable opsonization, a species-specific 'Marker of Self' CD47, and target physical properties. PMID: 26172292
Targeting CD47 Enhances the Efficacy of Anti-PD-1 and CTLA-4 in an Esophageal Squamous Cell Cancer Preclinical Model. PMID: 28337964
CD47 blockade as another immune checkpoint therapy for cancer. PMID: 26444633
Restoration of miR-340 controls pancreatic cancer cell CD47 expression to promote macrophage phagocytosis and enhance antitumor immunity. PMID: 32503944
Purification of CD47-streptavidin fusion protein from bacterial lysate using biotin-agarose affinity chromatography. PMID: 27110670
Novel CD47-dependent intercellular adhesion modulates cell migration. PMID: 15880429
CD47 Promotes Protective Innate and Adaptive Immunity in a Mouse Model of Disseminated Candidiasis. PMID: 26010544
CD47(low) status on CD4 effectors is necessary for the contraction/resolution of the immune response in humans and mice. PMID: 22870271
Innate immune 'self' recognition: a role for CD47-SIRPalpha interactions in hematopoietic stem cell transplantation. PMID: 18394962
On the mechanism of CD47 targeting in cancer. PMID: 22923695
The matricellular protein thrombospondin-1 globally regulates cardiovascular function and responses to stress via CD47. PMID: 22266027
Alternative 3' UTRs act as scaffolds to regulate membrane protein localization. PMID: 25896326
Nanoscale Metal-Organic Framework Co-delivers TLR-7 Agonists and Anti-CD47 Antibodies to Modulate Macrophages and Orchestrate Cancer Immunotherapy. PMID: 32658476
For research use only. Not for human or drug use.
