Catalog No.
PHE14001
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CD147/BSG (Gly140-Ala323).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Hepatoma-associated antigen,BSG,HAb18G,5F7,TCSF,OK blood group antigen,Collagenase stimulatory factor,CD147,Leukocyte activation antigen M6,Basigin,Extracellular matrix metalloproteinase inducer,EMMPRIN,Tumor cell-derived collagenase stimulatory factor
Purification
Purified by antigen affinity column.
Accession
P35613
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Multimodal nanoparticles co-delivering bevacizumab and dichloroacetate for dual targeting of neoangiogenesis and hyperglycolysis in glioblastoma treatment., PMID:40482922
Serum EMMPRIN/CD147 promotes the lung pre-metastatic niche in a D2A1 mammary carcinoma mouse model., PMID:40370456
Potentiating Antibody-Dependent Cellular Cytotoxicity in Triple-Negative Breast Cancer via the Humanized Anti-CD147 Antibody., PMID:40265417
Meplazumab, a CD147 antibody, for severe COVID-19: a double-blind, randomized, placebo-controlled, phase 3 clinical trial., PMID:40222976
EMMPRIN Correlated with β-CATENIN in Various t Stages of Colorectal Adenocarcinoma., PMID:40156418
Urinary Basigin/CD147 is a useful marker of acute T cell-mediated rejection in kidney transplant recipients., PMID:40125925
An Anti-CD147 Antibody-Drug Conjugate Mehozumab-DM1 is Efficacious Against Hepatocellular Carcinoma in Cynomolgus Monkey., PMID:39985225
Cyclophilin-CD147 interaction enables SARS-CoV-2 infection of human monocytes and their activation via Toll-like receptors 7 and 8., PMID:39963132
Detecting monogenic disorders in utero non-invasively based on fetal nucleated red blood cells highly-purified by multi-functional magnetic nanoparticles., PMID:39947792
Radioiodinated Nanobody immunoPET probe for in vivo detection of CD147 in pan-cancer., PMID:39549046
Engineering affinity of humanized ScFv targeting CD147 antibody: A combined approach of mCSM-AB2 and molecular dynamics simulations., PMID:39405982
The binding of extracellular cyclophilin A to ACE2 and CD147 triggers psoriasis-like inflammation., PMID:39096717
Quantitative Membrane Proteomics for Discovery of Actionable Drug Targets at the Surface of RAS-Driven Human Cancer Cells., PMID:39052212
Tofacitinib Regulates Endostatin via Effects on CD147 and Cathepsin S., PMID:39000375
Engineered CD147-Deficient THP-1 Impairs Monocytic Myeloid-Derived Suppressor Cell Differentiation but Maintains Antibody-Dependent Cellular Phagocytosis Function for Jurkat T-ALL Cells with Humanized Anti-CD147 Antibody., PMID:38928332
CD147 regulates the formation and function of immune synapses., PMID:38909549
CD147-K148me2-Driven Tumor Cell-Macrophage Crosstalk Provokes NSCLC Immunosuppression via the CCL5/CCR5 Axis., PMID:38873823
Metal-organic framework-interfaced ELISA probe enables ultrasensitive detection of extracellular vesicle biomarkers., PMID:38856318
Engineering Dimeric EGFR-directed IgA Antibodies Reveals a Central Role of CD147 during Neutrophil-mediated Tumor Cell Killing of Head and Neck Squamous Cancer Cells., PMID:38787053
Glucose Promotes EMMPRIN/CD147 and the Secretion of Pro-Angiogenic Factors in a Co-Culture System of Endothelial Cells and Monocytes., PMID:38672062
Preconditioning-Induced Facilitation of Lactate Release from Astrocytes Is Essential for Brain Ischemic Tolerance., PMID:38604775
Comparative assessment of different anti-CD147/Basigin 2 antibodies as a potential therapeutic anticancer target by molecular modeling and dynamic simulation., PMID:38587771
The use of human iPSC-derived alveolar organoids to explore SARS-CoV-2 variant infections and host responses., PMID:38572923
Hypoxia-activated ADCC-enhanced humanized anti-CD147 antibody for liver cancer imaging and targeted therapy with improved selectivity., PMID:38469549
Soluble CD147 regulates endostatin via its effects on the activities of MMP-9 and secreted proteasome 20S., PMID:38318187
CD147 induces asthmatic airway remodeling and activation of circulating fibrocytes in a mouse model of asthma., PMID:38178133
CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis., PMID:38166463
Novel Pharmacological Treatment Options of Steroid-Refractory Graft-versus-Host Disease., PMID:38094101
CD147: an integral and potential molecule to abrogate hallmarks of cancer., PMID:38023152
Multiplex Quantification of Exosomes via Multiple Types of Nanobeads Labeling Combined with Laser Scanning Detection., PMID:37812687
124I-labeled anti-CD147 antibody for noninvasive detection of CD147-positive pan-cancers: construction and preclinical studies., PMID:37749238
SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer., PMID:37692516
Comprehensive cell surface protein profiling of human mesenchymal stromal cells from peritoneal dialysis effluent and comparison with those from human bone marrow and adipose tissue., PMID:37603218
Identification of CD147-positive extracellular vesicles as novel non-invasive biomarkers for the diagnosis and prognosis of colorectal cancer., PMID:37562522
Repurposing Niclosamide as a Novel Anti-SARS-CoV-2 Drug by Restricting Entry Protein CD147., PMID:37509657
CD147 monoclonal antibody attenuates abdominal aortic aneurysm formation in angiotensin II-Infused apoE-/- mice., PMID:37393837
Dextran-doxorubicin prodrug nanoparticles conjugated with CD147 monoclonal antibody for targeted drug delivery in hepatoma therapy., PMID:37331192
Combination Therapy With CD147-Targeted Nanoparticles Carrying Phenformin Decreases Lung Cancer Growth., PMID:37303292
Differential Effects of Anti-PD-1/PD-L1 Checkpoint Inhibitors on Adhesion Molecules and Cytokine Secretion by THP-1 Monocytes., PMID:37247886
Diabetes, COVID-19, and questions unsolved., PMID:37209039
Repurposing niclosamide as a novel anti-SARS-Cov-2 drug by restricting entry protein CD147., PMID:37090542
Spike Protein Impairs Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying Cardiac Injury in COVID-19., PMID:36980218
Meplazumab in hospitalized adults with severe COVID-19 (DEFLECT): a multicenter, seamless phase 2/3, randomized, third-party double-blind clinical trial., PMID:36717539
Immunological and metabolic characteristics of the Omicron variants infection., PMID:36681668
Safety, Biodistribution, and Dosimetry Study of Meplazumab, a Potential COVID-19 Therapeutic Drug, with 131I-Labeling and SPECT Imaging., PMID:36668905
SARS-CoV-2 Spike Protein Induces Hemagglutination: Implications for COVID-19 Morbidities and Therapeutics and for Vaccine Adverse Effects., PMID:36555121
CD147 contributes to SARS-CoV-2-induced pulmonary fibrosis., PMID:36424379
ACE2-Independent Alternative Receptors for SARS-CoV-2., PMID:36423144
Novel Antibody Exerts Antitumor Effect through Downregulation of CD147 and Activation of Multiple Stress Signals., PMID:36385956
Extracellular Vesicles Isolated from Plasma of Multiple Myeloma Patients Treated with Daratumumab Express CD38, PD-L1, and the Complement Inhibitory Proteins CD55 and CD59., PMID:36359760
For research use only. Not for human or drug use.
