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Research Grade Ravulizumab (DHB90001)

Host species:Humanized
Isotype:IgG2-G4-kappa
Applications:Research Grade Biosimilar
Expression system:Mammalian Cells
Overview

Catalog No.

DHB90001

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG2-G4-kappa

Clonality

Monoclonal

Target

CPAMD4, C5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, Complement C5

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P01031

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

ALXN-1210, ravulizumab-cwvz, CAS: 1803171-55-2

Clone ID

Ravulizumab

Data Image
  • Bioactivity
    Detects Human C5 in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Ravulizumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Ravulizumab: First Global Approval, PMID: 30767127

Ravulizumab (ALXN1210) vs eculizumab in C5-inhibitor-experienced adult patients with PNH: the 302 study, PMID: 30510079

Ravulizumab (ALXN1210) vs eculizumab in adult patients with PNH naive to complement inhibitors: the 301 study, PMID: 30510080

Ravulizumab, PMID: 31643795

Ravulizumab (ALXN1210) in patients with paroxysmal nocturnal hemoglobinuria: results of 2 phase 1b/2 studies, PMID: 30171081

Ravulizumab, PMID: 30694619

Ravulizumab for the treatment of paroxysmal nocturnal hemoglobinuria, PMID: 32011183

The long-acting C5 inhibitor, ravulizumab, is efficacious and safe in pediatric patients with atypical hemolytic uremic syndrome previously treated with eculizumab, PMID: 33048203

Monitoring Ravulizumab effect on complement assays, PMID: 33321132

A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trial, PMID: 32660611

The long-acting C5 inhibitor, Ravulizumab, is effective and safe in adult patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment, PMID: 32299680

Ravulizumab: a novel C5 inhibitor for the treatment of paroxysmal nocturnal hemoglobinuria, PMID: 31534662

Characterization of breakthrough hemolysis events observed in the phase 3 randomized studies of ravulizumab versus eculizumab in adults with paroxysmal nocturnal hemoglobinuria, PMID: 31949012

Pharmacokinetic and pharmacodynamic effects of ravulizumab and eculizumab on complement component 5 in adults with paroxysmal nocturnal haemoglobinuria: results of two phase 3 randomised, multicentre studies, PMID: 32449174

Ravulizumab: a complementary option for PNH, PMID: 30733201

Is ravulizumab the new treatment of choice for atypical hemolytic uremic syndrome (aHUS)?, PMID: 32444092

Ravulizumab: A Review in Atypical Haemolytic Uraemic Syndrome, PMID: 33738756

A US cost-minimization model comparing ravulizumab versus eculizumab for the treatment of atypical hemolytic uremic syndrome, PMID: 33001704

One-year efficacy and safety of ravulizumab in adults with paroxysmal nocturnal hemoglobinuria naïve to complement inhibitor therapy: open-label extension of a randomized study, PMID: 33178408

Patient preferences and quality of life implications of ravulizumab (every 8 weeks) and eculizumab (every 2 weeks) for the treatment of paroxysmal nocturnal hemoglobinuria, PMID: 32886668

No evidence for hypogammaglobulinemia in patients with paroxysmal nocturnal hemoglobinuria (PNH) chronically treated with ravulizumab, PMID: 32218584

Antibodies to watch in 2019, PMID: 30516432

Cost-Utility Analysis of Ravulizumab Compared with Eculizumab in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria, PMID: 32519233

Results from multinational phase 3 studies of ravulizumab (ALXN1210) versus eculizumab in adults with paroxysmal nocturnal hemoglobinuria: subgroup analysis of Japanese patients, PMID: 32869125

New Therapeutic Targets and Treatment Options for Thrombotic Microangiopathy: Caplacizumab and Ravulizumab, PMID: 32715723

The long-acting C5 inhibitor, ravulizumab, is effective and safe in pediatric patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment, PMID: 33307104

Eculizumab and Beyond: The Past, Present, and Future of Complement Therapeutics, PMID: 31703946

Cost burden of breakthrough hemolysis in patients with paroxysmal nocturnal hemoglobinuria receiving ravulizumab versus eculizumab, PMID: 32856539

Emerging drugs for the treatment of neuromyelitis optica, PMID: 32731771

Anti-complement Treatment for Paroxysmal Nocturnal Hemoglobinuria: Time for Proximal Complement Inhibition? A Position Paper From the SAAWP of the EBMT, PMID: 31258525

Overview of current and emerging therapies for amytrophic lateral sclerosis, PMID: 32840332

One-year outcomes from a phase 3 randomized trial of ravulizumab in adults with paroxysmal nocturnal hemoglobinuria who received prior eculizumab, PMID: 33301613

Ravulizumab for the Treatment of aHUS in Adults: Improving Quality of Life, PMID: 34169186

Efficacy and safety of the long-acting C5 inhibitor ravulizumab in patients with atypical hemolytic uremic syndrome triggered by pregnancy: a subgroup analysis, PMID: 33407224

Switching From High-Dose Eculizumab to Ravulizumab in Paroxysmal Nocturnal Hemoglobinuria: A Case Report, PMID: 32803134

Disseminated gonococcal infection in a patient with paroxysmal nocturnal hemoglobinuria having received ravulizumab and meningococcal vaccine, PMID: 32624359

Pharmacokinetic and Pharmacodynamic Evaluation of Ravulizumab in Adults with Severe Coronavirus Disease 2019, PMID: 33826106

Erratum to "Rondeau E, Scully M, Ariceta G, Barbour T, Cataland S, Heyne N, Miyakawa Y, Ortiz S, Swenson E, Vallee M, Yoon S-S, Kavanagh D, Haller H; on behalf of the 311 Study Group. The long-acting C5 inhibitor, Ravulizumab, is effective and safe in adult patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment" Kidney Int. 2020;97:1287-1296, PMID: 33276869

Comparative effectiveness of pegcetacoplan versus ravulizumab in patients with paroxysmal nocturnal hemoglobinuria previously treated with eculizumab: a matching-adjusted indirect comparison, PMID: 34445916

Repurposed immunomodulatory drugs for Covid-19 in pre-ICu patients - mulTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19 - Repurposed Drugs (TACTIC-R): A structured summary of a study protocol for a randomised controlled trial, PMID: 32641154

Safety of current treatments for paroxysmal nocturnal hemoglobinuria, PMID: 33249943

Correction to: The long-acting C5 inhibitor, ravulizumab, is efficacious and safe in pediatric patients with atypical hemolytic uremic syndrome previously treated with eculizumab, PMID: 33296010

[Antibody therapy for paroxysmal nocturnal hemoglobinuria], PMID: 32908057

Pharmaceutical Approval Update, PMID: 30828229

The potential of individualized dosing of ravulizumab to improve patient-friendliness of paroxysmal nocturnal haemoglobinuria treatment at reduced costs, PMID: 33512711

Correction to: Ravulizumab: A Review in Atypical Haemolytic Uraemic Syndrome, PMID: 33871820

Correction to: Ravulizumab: A Review in Atypical Haemolytic Uraemic Syndrome, PMID: 34245447

Paroxysmal nocturnal hemoglobinuria: current treatments and unmet needs, PMID: 33356783

Long-Term Efficacy and Safety of the Long-Acting Complement C5 Inhibitor Ravulizumab for the Treatment of Atypical Hemolytic Uremic Syndrome in Adults, PMID: 34169200

Second-Generation C5 Inhibitors for Paroxysmal Nocturnal Hemoglobinuria, PMID: 31916226

Datasheet

Document Download

Research Grade Ravulizumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

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Research Grade Ravulizumab [DHB90001]
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