Research Grade Gremubamab (DXX03401)

Catalog No.

DXX03401

Expression system

Mammalian Cells

Species reactivity

P. aeruginosa

Host species

Humanized

Isotype

VH-CH1-VH-V-KAPPA-CH2-CH3

Clonality

Monoclonal

Target

PcrV & Psl

Concentration

0.87 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O30527

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

Bispecific, MEDI3902, CAS: 1800381-36-5

Clone ID

Gremubamab

Treatment Efficacy of MEDI3902 in Pseudomonas aeruginosa Bloodstream Infection and Acute Pneumonia Rabbit Models, PMID: 31160288

Bispecific antibody targets multiple Pseudomonas aeruginosa evasion mechanisms in the lung vasculature, PMID: 28463232

MEDI3902 Correlates of Protection against Severe Pseudomonas aeruginosa Pneumonia in a Rabbit Acute Pneumonia Model, PMID: 29483116

Pseudomonas aeruginosa PcrV and Psl, the Molecular Targets of Bispecific Antibody MEDI3902, Are Conserved Among Diverse Global Clinical Isolates, PMID: 30016475

Phase 1 study of MEDI3902, an investigational anti-Pseudomonas aeruginosa PcrV and Psl bispecific human monoclonal antibody, in healthy adults, PMID: 30107283

Document Download

Research Grade Gremubamab.pdf