Catalog No.
YVV02202
Expression system
E. coli
Species
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Protein length
Phe16-Ile121
Predicted molecular weight
24.76 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P0DTC8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ORF8 protein, ORF8, Non-structural protein 8, ns8
Correction to "Alignment of Human KAT2A (GCN5) Histone Acetyltransferase and SARS-CoV-2 Orf8 Viral Proteins"., PMID:40486955
Acute COVID-19 and LongCOVID syndrome - molecular implications for therapeutic strategies - review., PMID:40313948
Targeting CTP synthetase 1 to restore interferon induction and impede nucleotide synthesis in SARS-CoV-2 infection., PMID:40298378
Prior SARS-CoV-2 infection affects adaptive immune responses to Omicron BA.4/BA.5 mRNA booster., PMID:40044048
Induction of the Inflammasome by the SARS-CoV-2 Accessory Protein ORF9b, Abrogated by Small-Molecule ORF9b Homodimerization Inhibitors., PMID:39902616
A comprehensive review of current insights into the virulence factors of SARS-CoV-2., PMID:39878471
Identification of patient demographic, clinical, and SARS-CoV-2 genomic factors associated with severe COVID-19 using supervised machine learning: a retrospective multicenter study., PMID:39875869
Yip1 interacting factor homolog B mediates the unconventional secretion of ORF8 during SARS-CoV-2 infection., PMID:39811650
Non-spike protein inhibition of SARS-CoV-2 by natural products through the key mediator protein ORF8., PMID:39744515
SARS-CoV-2 ORF8 drives osteoclastogenesis in preexisting immune-mediated inflammatory diseases., PMID:39704167
Hidden evolutionary constraints dictate the retention of coronavirus accessory genes., PMID:39566499
Recombination across distant coronavirid species and genera is a rare event with distinct genomic features., PMID:39560427
Transplacental SARS-CoV-2 protein ORF8 binds to complement C1q to trigger fetal inflammation., PMID:39390219
Viral coexistence and insertional mutations in the ORF8 region of SARS-CoV-2: A possible mechanism of nucleotide insertion., PMID:39368662
Emergence of crucial evidence catalyzing the origin tracing of SARS-CoV-2., PMID:39213297
Comparative Atlas of SARS-CoV-2 Substitution Mutations: A Focus on Iranian Strains Amidst Global Trends., PMID:39205305
Antibody Fc receptor binding and T cell responses to homologous and heterologous immunization with inactivated or mRNA vaccines against SARS-CoV-2., PMID:39191745
SARS-CoV-2 Accessory Protein ORF8 Targets the Dimeric IgA Receptor pIgR., PMID:39066171
T-Cell Epitope Mapping of SARS-CoV-2 Reveals Coordinated IFN-γ Production and Clonal Expansion of T Cells Facilitates Recovery from COVID-19., PMID:39066169
Progressive Evolutionary Dynamics of Gene-Specific ω Led to the Emergence of Novel SARS-CoV-2 Strains Having Super-Infectivity and Virulence with Vaccine Neutralization., PMID:38928018
Involvement of SARS-CoV-2 accessory proteins in immunopathogenesis., PMID:38837257
Design of multi-epitope chimeric vaccine against Monkeypox virus and SARS-CoV-2: A vaccinomics perspective., PMID:38801408
SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression., PMID:38781259
Characterization of antibody response to SARS-CoV-2 Orf8 from three waves of COVID-19 outbreak in Thailand., PMID:38768163
Abrogation of ORF8-IRF3 binding interface with Carbon nanotube derivatives to rescue the host immune system against SARS-CoV-2 by using molecular screening and simulation approaches., PMID:38734638
Monocyte response to SARS-CoV-2 protein ORF8 is associated with severe COVID-19 infection in patients with chronic lymphocytic leukemia., PMID:38654668
Comprehensive genomic analysis of the SARS-CoV-2 Omicron variant BA.2.76 in Jining City, China, 2022., PMID:38632523
Positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution., PMID:38615031
SARS-CoV-2 mitochondrial metabolic and epigenomic reprogramming in COVID-19., PMID:38614374
Genomic Surveillance and Mutation Analysis of SARS-CoV-2 Variants among Patients in Saudi Arabia., PMID:38543518
SARS-CoV-2 and UPS with potentials for therapeutic interventions., PMID:38490508
Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant., PMID:38332154
SARS-CoV-2 ORF8 as a Modulator of Cytokine Induction: Evidence and Search for Molecular Mechanisms., PMID:38275971
A survey of ORF8 sequence and immunoinformatics features during alpha, delta, and wild type peaks of the SARS-CoV-2 pandemic in Iran., PMID:38264170
A comprehensive profile of SARS-CoV-2 variants spreading during the COVID-19 pandemic: a genomic characterization study from Chhattisgarh State, India., PMID:38238530
Analysis of SARS-CoV-2 genome evolutionary patterns., PMID:38197644
Oligomer formation of SARS-CoV-2 ORF8 through 73YIDI76 motifs regulates immune response and non-infusion antiviral interactions., PMID:38094081
An ncRNA transcriptomics-based approach to design siRNA molecules against SARS-CoV-2 double membrane vesicle formation and accessory genes., PMID:38087193
Serological assays for differentiating natural COVID-19 infection from vaccine induced immunity., PMID:38056114
Defining Distinct RNA-Protein Interactomes of SARS-CoV-2 Genomic and Subgenomic RNAs., PMID:38043095
Surveillance of SARS-CoV-2 immunogenicity: loss of immunodominant HLA-A*02-restricted epitopes that activate CD8+ T cells., PMID:38022506
The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm., PMID:37891014
An interferon-integrated mucosal vaccine provides pan-sarbecovirus protection in small animal models., PMID:37875475
Genome analysis of SARS-CoV-2 isolates from a population reveals the rapid selective sweep of a haplotype carrying many pre-existing and new mutations., PMID:37658381
SARS-CoV-2 ORF8 accessory protein is a virulence factor., PMID:37623322
Polypharmacology guided drug repositioning approach for SARS-CoV2., PMID:37556478
SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling., PMID:37545510
Deciphering the evolutionary mechanisms of SARS-CoV-2: Absence of ORF8 protein and its potential advantage in the emergence of viral lineages., PMID:37534900
Potential Therapeutic Target and Vaccines for SARS-CoV-2., PMID:37513773
SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic., PMID:37450559
For research use only. Not for human or drug use.
