Catalog No.
YHJ69501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val46-Asp218
Predicted molecular weight
21.6 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NZH6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FIL1Z, IL37, Interleukin-1-related protein, IL-23, IL1F7, IL-37, IL1RP1, FIL1 zeta, IL-1X, Interleukin-23, IL-1F7, IL-1RP1, Interleukin-1 family member 7, Interleukin-37, Interleukin-1 homolog 4, Interleukin-1 zeta, IL-1H, IL-1H4, IL-1 zeta, IL1H4
Altered Serum IL-35 Levels and IL-37 Gene Expression in Patients with Parkinson's Disease: Focus on Emerging Cytokines., PMID:40483561
IL-37 inhibited inflammation to improve gestational diabetes mellitus through the GSK3/NF-κB pathway., PMID:40474280
Interleukin-37 modulates microglial phenotype and inhibits inflammatory response via the MyD88/NF-κB pathway in lipopolysaccharide-induced neuroinflammation., PMID:40439750
The Potential Contribution of the IL-37/IL-18/IL-18BP/IL-18R Axis in the Pathogenesis of Sjögren's Syndrome., PMID:40430016
Interleukin-37 Suppresses the Function of Type 2 Follicular Helper T in Allergic Rhinitis., PMID:40427088
IL-37 improves palmitic acid-induced lipid deposition in liver cells by inhibiting ferroptosis to regulate macrophage polarization., PMID:40382950
Neuroinflammation and Amyotrophic Lateral Sclerosis: Recent Advances in Anti-Inflammatory Cytokines as Therapeutic Strategies., PMID:40332510
IL-37 Protects Against Ventilator-Induced Lung Injury by Inhibiting NLRP3 Activation., PMID:40325829
Interleukin-37 reduces lipopolysaccharide induced matrix metalloproteinase-9 in gingival epithelial cells., PMID:40281482
IL-37 Alleviates Sepsis-Induced Lung Injury by Inhibiting Inflammatory Response Through the TGF-β/Smad3 Pathway., PMID:40270428
Salivary Biomarkers of Inflammasome Activation in Unstable Periodontitis: A Case-Control Study., PMID:40267956
Human regulatory B cells suppress autoimmune disease primarily via interleukin-37., PMID:40250016
Alzheimer's disease as an auto-innate immune pathology with potential cell trans-differentiation and enhanced trained immunity in 3xTg-AD mouse model., PMID:40232249
The stress and the alarmin-like cytokine interleukin-37 mediated extracellular and intracellular signal pathways., PMID:40209639
In vivo study on IL-37 inhibition of malignant melanoma metastasis., PMID:40195660
The distinct roles of IL-37 and IL-38 in non-small cell lung carcinoma and their clinical implications., PMID:40191189
Aging Impairs the Capacity of Cardiac Functional Recovery Following Endotoxemia: Modulation of Myocardial Klotho Level for Remedy., PMID:40158469
FCGR1A(CD64) expression on monocyte subsets and FIL1Z(IL-37) serum level as biomarkers of rheumatoid arthritis activity: A case controlled study and in silico analysis., PMID:40088754
AAV9-delivery of interleukin-37b gene prevents recurrent herpetic stromal keratitis via the SIGIRR pathway in mice., PMID:40043913
[Research advance on the role of interleukin-18, interleukin-37b and basophils in sepsis]., PMID:39968592
Interleukin-37 attenuates aortic valve lesions by inhibiting N6-methyladenosine-mediated interleukin-1 receptor-associated kinase M degradation., PMID:39913240
Epigenetic mechanisms underlying endometrial cancer outcomes: race-specific patterns of DNA methylation associated with molecular subtypes and survival., PMID:39873457
Computational modeling of the anti-inflammatory complexes of IL37., PMID:39854883
A review of cutting-edge biomarkers for diagnosing coronary artery disease., PMID:39854741
Kuiyangling Enema Alleviates Ulcerative Colitis Mice by Reducing Levels of Intestinal NETs and Promoting HuR/VDR Signaling., PMID:39802513
IL-37 attenuated HPV induced inflammation of oral epithelial cells via inhibiting PI3K/AKT/mTOR., PMID:39736667
Cardiac fibroblast-specific expression of IL-37 confers the protective effects on fibrosis in diabetic cardiomyopathy mice by regulating SOCS3-STAT3 axis., PMID:39734646
Interleukin-37 promotes wound healing in diabetic mice by inhibiting the MAPK/NLRP3 pathway., PMID:39714100
Prognostic Value of Serum Interleukin-37 in Patients with Acute Respiratory Distress Syndrome., PMID:39698874
IL-37 Isoform A Prevents Collagen-Induced Arthritis in Mice by Modulating the Th17/Treg Balance via IL1R8 Receptors., PMID:39684587
Nasal secretions trace epithelial type 2 response to allergen-specific immunotherapy., PMID:39660695
Therapeutic Potential of IL-37 in Cervical Cancer: Suppression of Tumour Progression and Enhancement of CD47-Mediated Macrophage Phagocytosis., PMID:39620401
The effect and mechanism of IL-37d on neutrophil recruitment in the early stage of tumor metastasis in the lungs., PMID:39612007
Potential and limitations of IL-37, a cytokine targeted for therapy of systemic lupus erythematosus: A Systematic Review., PMID:39566387
IL-37 suppresses CNS autoimmunity by increasing the frequency of Treg cells and reducing CD4 + T cell-derived IL-10 production., PMID:39563375
Potential pro-tumour cytokine in oral squamous cellular carcinoma: IL37., PMID:39500733
Analysis of the role of IL-1 family and related genes in head and neck squamous cell carcinoma., PMID:39461030
Recombinant expression, downstream optimization, and therapeutic evaluation of recombinant human interleukin-37 for cancer therapy., PMID:39424749
Jianpi qingre tongluo prescription alleviates the senescence-associated secretory phenotype with osteoarthritis by regulating STAG1/TP53/P21 signaling pathway., PMID:39423944
The role of selected cytokines from the interleukin-1 family in the peritoneal fluid of women with endometriosis., PMID:39411821
Expanding Role of Interleukin-1 Family Cytokines in Acute Ischemic Stroke., PMID:39408843
Pulsed electromagnetic fields inhibit IL-37 to alleviate CD8+ T cell dysfunction and suppress cervical cancer progression., PMID:39404933
IL-37 Inhibits Inflammation of Lacrimal Gland in Dry Eye Mice via the IL-37-PTEN-NFκB Signaling Pathway., PMID:39353047
The Protective Role of Interleukin-37 in Cardiovascular Diseases through Ferroptosis Modulation., PMID:39337246
Insights into the multifaceted role of interleukin-37 on human immune cell regulation., PMID:39307482
Interleukin(IL)-37 attenuates isoproterenol (ISO)-induced cardiac hypertrophy by suppressing JAK2/STAT3-signaling associated inflammation and oxidative stress., PMID:39293311
Interleukin-37 exacerbates liver inflammation and promotes IFN-γ production in NK cells., PMID:39260304
Enhanced IL-37-IL-1R8 axis is negatively associated with inflammatory and clinical severity of chronic rhinosinusitis with nasal polyps., PMID:39220569
The role of IL-37 in gastrointestinal diseases., PMID:39206201
Epidermal proteomics demonstrates Elafin as a psoriasis-specific biomarker and highlights increased anti-inflammatory activity around psoriatic plaques., PMID:39157924
For research use only. Not for human or drug use.
