Research Grade Nesvacumab (DHA42303)

Catalog No.

DHA42303

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG1-nd

Clonality

Monoclonal

Target

ANG-2, ANGPT2, Angiopoietin-2

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O15123

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

REGN-910, CAS: 1296818-77-3

Clone ID

Nesvacumab

Tie-2/Angiopoietin pathway modulation as a therapeutic strategy for retinal disease, PMID: 31513439

Innovative therapies for neovascular age-related macular degeneration, PMID: 31298960

Emerging vascular endothelial growth factor antagonists to treat neovascular age-related macular degeneration, PMID: 28756707

A Phase I First-in-Human Study of Nesvacumab (REGN910), a Fully Human Anti-Angiopoietin-2 (Ang2) Monoclonal Antibody, in Patients with Advanced Solid Tumors, PMID: 26490310

Aflibercept and Ang1 supplementation improve neoadjuvant or adjuvant chemotherapy in a preclinical model of resectable breast cancer, PMID: 27841282

Document Download

Research Grade Nesvacumab.pdf