Catalog No.
YHJ01801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu544-Ser806
Predicted molecular weight
31.74 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q5JRX3
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Pitrilysin metalloproteinase 1, hMP1, MP1, Metalloprotease 1, PREP, KIAA1104, Presequence protease, mitochondrial, PITRM1, hPreP
Note
For research use only.
Cloning, expression, and characterization of human metalloprotease 1: a novel member of the pitrilysin family of metalloendoproteases., PMID:10360838
Association of gene polymorphisms with chronic kidney disease in Japanese individuals., PMID:19724895
The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors., PMID:19877269
Genetic and biochemical studies of SNPs of the mitochondrial A beta-degrading protease, hPreP., PMID:19962426
Identification of putative SNPs in progressive retinal atrophy affected Canis lupus familiaris using exome sequencing., PMID:26515695
Perturbation of cellular proteostasis networks identifies pathways that modulate precursor and intermediate but not mature levels of frataxin., PMID:26671574
Defective PITRM1 mitochondrial peptidase is associated with Aβ amyloidotic neurodegeneration., PMID:26697887
Amyloid-β in mitochondrial disease: mutation in a human metallopeptidase links amyloidotic neurodegeneration with mitochondrial processing., PMID:26813924
Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin., PMID:29183787
An Exome-Wide Association Study Identifies New Susceptibility Loci for Age of Smoking Initiation in African- and European-American Populations., PMID:29216386
Functional requirement for human pitrilysin metallopeptidase 1 arginine 183, mutated in amyloidogenic neuropathy., PMID:29383861
Systematic analysis reveals long noncoding RNAs regulating neighboring transcription factors in human cancers., PMID:29753811
Mitochondrial PITRM1 peptidase loss-of-function in childhood cerebellar atrophy., PMID:29764912
Functional coupling of presequence processing and degradation in human mitochondria., PMID:32491259
Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids., PMID:32632204
Expression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation., PMID:32857715
In-frame deletion in canine PITRM1 is associated with a severe early-onset epilepsy, mitochondrial dysfunction and neurodegeneration., PMID:33835239
Gain of PITRM1 peptidase in cortical neurons affords protection of mitochondrial and synaptic function in an advanced age mouse model of Alzheimer's disease., PMID:33951271
Role of PITRM1 in Mitochondrial Dysfunction and Neurodegeneration., PMID:34356897
DELE1 tracks perturbed protein import and processing in human mitochondria., PMID:35388015
PITRM1 interaction studies with amyloidogenic nonapeptide mutants of familial Alzheimer's disease., PMID:35751131
Functional genomics analysis reveals the evolutionary adaptation and demographic history of pygmy lorises., PMID:36161902
Exploring Whether Iron Sequestration within the CNS of Patients with Alzheimer's Disease Causes a Functional Iron Deficiency That Advances Neurodegeneration., PMID:36979320
In silico exploration of antioxidants as oxidation protectant for PITRM1 peptidase activity, an Alzheimer disease target., PMID:37218421
PPAR-gamma agonist pioglitazone recovers mitochondrial quality control in fibroblasts from PITRM1-deficient patients., PMID:37576821
Enhancing mitochondrial proteolysis alleviates alpha-synuclein-mediated cellular toxicity., PMID:38906862
Exploiting Mitochondria by Triggering a Faulty Unfolded Protein Response Leads to Effective Cardioprotection., PMID:39744160
For research use only. Not for human or drug use.
