Catalog No.
YHH37201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro59-Asp414
Predicted molecular weight
41.05 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16790
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Membrane antigen MN, P54/58N, Carbonic anhydrase 9, Renal cell carcinoma-associated antigen G250, CA-IX, CAIX, pMW1, Carbonic anhydrase IX, RCC-associated antigen G250, Carbonate dehydratase IX, CA9, MN, G250
Oxindole-Coumarin Hybrids With Broad-Spectrum Anticancer Activity: Apoptosis Induction and Selective CA IX/XII Targeting., PMID:40492425
CA9-Positive Keloid Fibroblasts: Modulator of Local Inflammation Induced by the Hypoxic and Glycolysis-enhanced Microenvironment., PMID:40425327
Cooperative Role of Carbonic Anhydrase IX/XII in Driving Tumor Invasion and Metastasis: A Novel Targeted Therapeutic Strategy., PMID:40422196
Mechanism Analysis of Zuogui and Yougui Pills on Diabetic Nephropathy Through Transcriptional Regulatory Networks of HIF1A and PPARA., PMID:40417738
In vitro impact of Streptococcus mitis on the inhibition of oral cancer cell proliferation via mitotic modulation., PMID:40415961
Carbonic anhydrase IX downregulation linked to disruption of HIF-1, NFκB and STAT3 pathways as a new mechanism of ibuprofen anti-cancer effect., PMID:40408503
Transcription factor ZNF266 suppresses cancer progression by modulating CA9-mediated intracellular pH alteration in lung adenocarcinoma., PMID:40389968
Small Organic Carbonic Anhydrase IX Ligands from DNA-Encoded Chemical Libraries for Tumor-Targeted Delivery of Radionuclides., PMID:40378292
Rationally designed Pyrazolo[1,5-a]pyrimidines as dual inhibitors of CA IX/XII and CDK6: A novel approach for NSCLC treatment., PMID:40373635
Pharmacological inhibition of hypoxia induced acidosis employing a CAIX inhibitor sensitizes gemcitabine resistant PDAC cells., PMID:40369181
Interleukin-6 regulates human ODAM gene expression in gingival epithelial cells., PMID:40350767
Development of new anticancer thiadiazole-sulfonamides as dual EGFR/carbonic anhydrase inhibitors., PMID:40337848
[Clinicopathological characteristics of high-grade succinate dehydrogenase-deficient renal cell carcinoma]., PMID:40302581
A comparative study of the epithelial regeneration capacities of two biomaterials in vitro., PMID:40281524
Bioactive components of Jiedu Sangen decoction against colorectal cancer: A novel and comprehensive research strategy for natural drug development., PMID:40279966
Synthesis and Construction of I-124 Labeled Small Molecular Probe for Noninvasive PET Imaging of CAIX Expression., PMID:40205275
Bifunctional compounds for targeted degradation of carbonic anhydrase IX through integrin-facilitated lysosome degradation., PMID:40204090
Integrated seminal plasma metabolomics and lipidomics profiling highlight distinctive signature of varicocele patients with male infertility., PMID:40195858
O-derivatization of natural tropolone and β-thujaplicin leading to effective inhibitors of human carbonic anhydrases IX and XII., PMID:40179613
Electric field-induced conformational dynamics of CA9: a potential biomarker for glioblastoma multiforme., PMID:40159762
Antibody-drug conjugates and radioconjugates targeting carbonic anhydrase IX and XII in hypoxic tumors: Bench to clinical applications., PMID:40154235
Synthesis, Preclinical Characterizations and Imaging Studies of [18F]AlF-Labeled NY104, a CAIX-Targeting Diagnostic Agent., PMID:40152075
The Role of Caspase-1 and Caspase-4 in Modulating Gingival Epithelial Cell Responses to Aggregatibacter actinomycetemcomitans Infection., PMID:40137780
New benzimidazole derivatives containing hydrazone group as anticancer agents: Inhibition of carbonic anhydrase IX and molecular docking studies., PMID:40123434
NDRG1 alleviates Erastin-induced ferroptosis of hepatocellular carcinoma., PMID:40119318
Dinaciclib Interrupts Cell Cycle and Induces Apoptosis in Oral Squamous Cell Carcinoma: Mechanistic Insights and Therapeutic Potential., PMID:40076816
PFDN1 silencing disrupts critical cancer pathways in triple-negative breast cancer: investigating migration, cell cycle, and apoptosis as a new target therapy., PMID:40063241
METTL3 enhances esophageal squamous cell carcinoma progression by suppressing ferroptosis through the PBX3/CA9 cascade., PMID:40048803
Causal inference study of plasma proteins and blood metabolites mediating the effect of obesity-related indicators on osteoporosis., PMID:40041284
The Diagnostic Value of Plasma Small Extracellular Vesicle-Derived CAIX Protein in Prostate Cancer and Clinically Significant Prostate Cancer: A Study on Predictive Models., PMID:40013658
Design and Synthesis of 3-(Phenylsulfonamido)benzamide Derivatives as Potent Carbonic Anhydrase IX Inhibitors: Biological Evaluations and Molecular Modeling Studies., PMID:40007186
[177Lu]Lu-XYIMSR-01: A Novel CAIX-Targeted Radiotherapeutic for Enhanced Treatment of Malignant Glioma., PMID:39977538
Molecular dynamics simulation reveals structural insights into isozyme selectivity of carbonic anhydrase XII inhibitors in hypoxic tumor microenvironment., PMID:39965264
Carbonic anhydrase-9-targeted near-infrared photoimmunotherapy as a theranostic modality for clear cell renal cell carcinoma., PMID:39936451
Signaling pathways of pro-IL-1β production induced by mechanical stress in gingival epithelial cells., PMID:39921162
Cytomorphology and clinicopathologic correlation of TFE3-rearranged renal cell carcinoma., PMID:39912368
Design of Rigid Compounds to Enhance Selectivity for Carbonic Anhydrase IX., PMID:39905940
Clinicopathological and genomic analysis of pediatric pheochromocytoma and sympathetic paraganglioma., PMID:39894509
A series of benzensulfonamide derivatives as new potent carbonic anhydrase IX and XII inhibitors., PMID:39878534
Titanium particle-induced inflammasome in human gingival epithelial cells., PMID:39873089
Combination of Carbonic Anhydrase Isoform IX Inhibitors and Gefitinib Suppresses on the Invasive Potential of Non-Small Cell Lung Cancer Cells., PMID:39865035
Carbonic Anhydrase IX Targeted Polyaspartamide fluorescent Probes for Tumor imaging., PMID:39835180
β1 Integrin/FAK signaling regulates interleukin-8 production in human gingival epithelial Ca9-22 cells., PMID:39826873
Curcumin pretreatment prevents butyrate-induced cell death and release of damage-associated molecular patterns on gingival epithelial Ca9-22 cells., PMID:39824384
Design, Synthesis, and In Vitro Evaluation of Aromatic Sulfonamides as Human Carbonic Anhydrase I, II, IX, and XII Inhibitors and Their Antioxidant Activity., PMID:39812110
Transcriptional regulation of human follicular dendritic cell-secreted protein gene by interleukin-6., PMID:39776305
Carbonic anhydrase IX inhibition as a path to treat neuroblastoma., PMID:39776083
Discovery of Carbonic Anhydrase 9 as a Novel CLEC2 Ligand in a Cellular Interactome Screen., PMID:39768175
Ref-1 is overexpressed in neovascular eye disease and targetable with a novel inhibitor., PMID:39756006
Upregulation of RCN2 accelerates tumor progression and indicates poor prognosis in OSCC., PMID:39730259
For research use only. Not for human or drug use.
