Catalog No.
YHG76001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg21-Lys229
Predicted molecular weight
25.61 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14213
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL-27B, Interleukin-27 subunit beta, EBI3, Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein, IL27B, IL-27 subunit beta
Altered Serum IL-35 Levels and IL-37 Gene Expression in Patients with Parkinson's Disease: Focus on Emerging Cytokines., PMID:40483561
Plasma proteome profiling of massive perivillous fibrin deposition (MPFD) in women with recurrent Miscarriages: Pathophysiological insights and biomarker discovery., PMID:40472641
The role of IL-39 in autoimmune diseases: From general to immunopathogenesis., PMID:40440970
High interleukin-35 expression is associated with the severity of rheumatic mitral stenosis., PMID:40264784
Dendrobium huoshanense polysaccharide inhibits NSCLC proliferation and immune evasion via FXR1-IL-35 axis signaling pathway., PMID:40259042
Interleukin-27 deletion has neuroprotective effects in the acute ischemic stage of cerebral infarction., PMID:40048763
IL35 modulates HBV-related HCC progression via IL6-STAT3 signaling., PMID:39984567
Epstein-Barr Virus-Induced 3 Attributes to TLR7-Mediated Splenomegaly., PMID:39876525
Harnessing IL-27: challenges and potential in cancer immunotherapy., PMID:39797931
Malignant behaviors and immune response in melanoma: Epstein-Barr virus induced gene 3 as a therapeutic target based on an in-vitro exploration., PMID:39726752
IL-35 May Prevent the Exacerbation of Aspiration Pneumonia Involving Porphyromonas gingivalis by Suppressing IL-17 Production., PMID:39725293
Interleukin-35: A key player managing pre-diabetes and chronic inflammatory type 1 autoimmune diabetes., PMID:39493554
Emerging Roles of IL-27 in Trophoblast Cells and Pregnancy Complications., PMID:39422056
Interleukin-27 Regulates Adaptative Immune Responses Associated With Control of Parasite Replication in Canine Leishmaniasis., PMID:39360782
Ebi3 Binding to IFN-γ and IL-10 Limits Their Function., PMID:39240167
Levilactobacillus brevis IBARAKI-TS3 Isolated From Pickles Promotes Production of Interleukin-10 via Toll-Like Receptor 2 in Human M2 Macrophages., PMID:39210693
Breakthroughs in road mapping IL-35 mediated immunotherapy for type-1 and autoimmune diabetes mellitus., PMID:38986251
Adaptive plasticity of natural interleukin-35-induced regulatory T cells (Tr35) that are required for T-cell immune regulation., PMID:38773985
An updated advancement of bifunctional IL-27 in inflammatory autoimmune diseases., PMID:38566992
Comparing anti-tumor and anti-self immunity in a patient with melanoma receiving immune checkpoint blockade., PMID:38443917
A glance on the role of IL-35 in systemic lupus erythematosus (SLE)., PMID:38290255
Deletion of IL-27p28 induces CD8 T cell immunity against colorectal tumorigenesis., PMID:38224627
DNA Copy Number Alterations and Copy Neutral Loss of Heterozygosity in Adult Ph-Negative Acute B-Lymphoblastic Leukemia: Focus on the Genes Involved., PMID:38139431
Expression and Prognostic Value of m6A RNA Methylation-Related Genes in Thyroid Cancer., PMID:38033847
Increased synthesis and intestinal expression of IL-39 in patients with inflammatory bowel disease., PMID:37968544
IL-27p28 specifically regulates MHC II expression in macrophages through CIITA., PMID:37944428
Human interleukin-12α and EBI3 are cytokines with anti-inflammatory functions., PMID:37878703
Ebi3 knockout aggravates experimental periodontitis via Th17 polarization., PMID:37534736
Recombinant protein EBI3 attenuates Clonorchis sinensis-induced liver fibrosis by inhibiting hepatic stellate cell activation in mice., PMID:37480105
Goat milk extracellular vesicles: immuno-modulation effects on porcine monocyte-derived macrophages in vitro., PMID:37469517
Toll-like Receptors and Cytokine Modulation by Goat Milk Extracellular Vesicles in a Model of Intestinal Inflammation., PMID:37446274
Interleukin-27 potentiates CD8+ T-cell-mediated antitumor immunity in chronic lymphocytic leukemia., PMID:37345470
IL-27-containing exosomes secreted by innate B-1a cells suppress and ameliorate uveitis., PMID:37334383
Antiviral response and immunopathogenesis of interleukin 27 in COVID-19., PMID:37310504
Human IL-35 Inhibits the Bioactivity of IL-12 and Its Interaction with IL-12Rβ2., PMID:37289499
JNK/c-Jun pathway activation is essential for HBx-induced IL-35 elevation to promote persistent HBV infection., PMID:36916737
The effect of lipid-lowering therapies on the pro-inflammatory and anti-inflammatory properties of vascular endothelial cells., PMID:36753488
The role of iTr35 cells in the inflammatory response and fibrosis progression of systemic sclerosis., PMID:36734529
INTERLEUKIN-35 DOWNREGULATES THE IMMUNE RESPONSE OF EFFECTOR CD4 + T CELLS VIA RESTRICTING HIGH MOBILITY GROUP BOX-1 PROTEIN-DEPENDENT AUTOPHAGY IN SEPSIS., PMID:36731088
Cell type specific IL-27p28 (IL-30) deletion in mice uncovers an unexpected regulatory function of IL-30 in autoimmune inflammation., PMID:36725904
Risk stratification of acute myeloid leukemia: Assessment using a novel prediction model based on ferroptosis-immune related genes., PMID:36653976
Investigation of IL-35 and IL-39, New Members of the IL-12 Family, in Different Clinical Presentations of Brucellosis., PMID:36645409
The IL-12 family cytokines in fish: Molecular structure, expression profile and function., PMID:36632929
IL-27 suppresses spring viremia of carp virus replication in zebrafish., PMID:36632914
Epstein-Barr virus-induced gene 3 commits human mesenchymal stem cells to differentiate into chondrocytes via endoplasmic reticulum stress sensor., PMID:36548354
[Expression of Tregs and IL-35 in Peripheral Blood of Patients with Newly Diagnosed Acute Myeloid Leukemia]., PMID:36476890
Reduced T Cell Priming in Microbially Experienced "Dirty" Mice Results from Limited IL-27 Production by XCR1+ Dendritic Cells., PMID:36426978
Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27., PMID:36261006
In vitro evaluation of immunomodulatory activities of goat milk Extracellular Vesicles (mEVs) in a model of gut inflammation., PMID:36179548
Evaluation of IL-23p19/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis., PMID:35986791
For research use only. Not for human or drug use.
