Catalog No.
YHG71101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg284-Asp630
Predicted molecular weight
41.21 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14123
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PDE1C, Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C, Cam-PDE 1C, 3',5'-cyclic-GMP phosphodiesterase, 3',5'-cyclic-AMP phosphodiesterase, Hcam3
Circ-PDE1C/miR-766-3p/SGTB axis regulates the IL-1β-induced apoptosis, inflammation and oxidative stress in human chondrocytes., PMID:39736775
Vinpocetine alleviates the abdominal aortic aneurysm progression via VSMCs SIRT1-p21 signaling pathway., PMID:39179867
Pharmacogenetic determinants of tenofovir diphosphate and lamivudine triphosphate concentrations in people with HIV/HBV coinfection., PMID:39078131
Fetal sex and the relative reactivity of human umbilical vein and arteries are key determinants in potential beneficial effects of phosphodiesterase inhibitors., PMID:38695358
Epigenetic Profiling of Type 2 Diabetes Mellitus: An Epigenome-Wide Association Study of DNA Methylation in the Korean Genome and Epidemiology Study., PMID:38137029
Role of Phosphodiesterase 1 in the Regulation of Real-Time cGMP Levels and Contractility in Adult Mouse Cardiomyocytes., PMID:38067187
Analysis of gut microbiome, host genetics, and plasma metabolites reveals gut microbiome-host interactions in the Japanese population., PMID:37935197
Important roles of Hif1a in maternal or adult BPA exposure induced pancreatic injuries., PMID:37460698
The photoreceptor protective cGMP-analog Rp-8-Br-PET-cGMPS interacts with cGMP-interactors PKGI, PDE1, PDE6, and PKAI in the degenerating mouse retina., PMID:36989379
Ionocyte-Specific Regulation of Cystic Fibrosis Transmembrane Conductance Regulator., PMID:36952679
Epigenome-wide DNA methylation study of whole blood in patients with sporadic amyotrophic lateral sclerosis., PMID:35853630
Microvascular Sex- and Age- Dependent Phosphodiesterase Expression., PMID:35822023
Structural Modifications of Nimodipine Lead to Novel PDE1 Inhibitors with Anti-pulmonary Fibrosis Effects., PMID:35666471
Endoplasmic reticulum stress mediates homocysteine-induced hypertrophy of cardiac cells through activation of cyclic nucleotide phosphodiesterase 1C., PMID:35538034
Molecular pathways dysregulated by Pb2+ exposure prompts pancreatic beta-cell dysfunction., PMID:35237425
Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm., PMID:34312235
Phosphodiesterases Expression during Murine Cardiac Development., PMID:33807511
Phosphodiesterase 1C integrates store-operated calcium entry and cAMP signaling in leading-edge protrusions of migrating human arterial myocytes., PMID:33789162
Longitudinal genetic studies of cognitive characteristics., PMID:33659785
FTO-Dependent N 6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling., PMID:32606006
Discovery of Novel Selective and Orally Bioavailable Phosphodiesterase-1 Inhibitors for the Efficient Treatment of Idiopathic Pulmonary Fibrosis., PMID:32603117
Amlexanox exerts anti-inflammatory actions by targeting phosphodiesterase 4B in lipopolysaccharide-activated macrophages., PMID:32504661
Transcriptome analysis and identification of genes associated with chicken sperm storage duration., PMID:32036969
An EPAC1/PDE1C-Signaling Axis Regulates Formation of Leading-Edge Protrusion in Polarized Human Arterial Vascular Smooth Muscle Cells., PMID:31757003
Mouse Cardiac Pde1C Is a Direct Transcriptional Target of Pparα., PMID:30469494
Inhibit a Phosphodiesterase to Treat Heart Failure?, PMID:30372138
Histone demethylase JMJD6 regulates cellular migration and proliferation in adipose-derived mesenchymal stem cells., PMID:30092848
Acute Enhancement of Cardiac Function by Phosphodiesterase Type 1 Inhibition., PMID:30030415
Multiprotein Complex With TRPC (Transient Receptor Potential-Canonical) Channel, PDE1C (Phosphodiesterase 1C), and A2R (Adenosine A2 Receptor) Plays a Critical Role in Regulating Cardiomyocyte cAMP and Survival., PMID:29871977
A dominant variant in the PDE1C gene is associated with nonsyndromic hearing loss., PMID:29860631
NMDA Receptor-mediated Ca2+ Influx in the Absence of Mg2+ Block Disrupts Rest: Activity Rhythms in Drosophila., PMID:29029290
Phosphodiesterase 1: A Unique Drug Target for Degenerative Diseases and Cognitive Dysfunction., PMID:28956339
PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries., PMID:28910498
Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells., PMID:28904388
Expression and function of phosphodiesterases (PDEs) in the rat urinary bladder., PMID:28687079
Novel selective PDE type 1 inhibitors cause vasodilatation and lower blood pressure in rats., PMID:28548283
Genetic and Targeted eQTL Mapping Reveals Strong Candidate Genes Modulating the Stress Response During Chicken Domestication., PMID:27974436
Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice., PMID:27548259
Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment., PMID:27427220
Associations between smoking behavior-related alleles and the risk of melanoma., PMID:27344179
Anatomical and molecular consequences of Unilateral Naris Closure on two populations of olfactory sensory neurons expressing defined odorant receptors., PMID:27189720
Microarray Expression Data Identify DCC as a Candidate Gene for Early Meningioma Progression., PMID:27096627
Phosphodiesterase 1 regulation is a key mechanism in vascular aging., PMID:26464516
An imputation-based genome-wide association study on traits related to male reproduction in a White Duroc × Erhualian F2 population., PMID:26425933
Cyclic nucleotide phosphodiesterase 1 and vascular aging., PMID:26374857
Modulation of Polycystic Kidney Disease Severity by Phosphodiesterase 1 and 3 Subfamilies., PMID:26374610
PDE1C negatively regulates growth factor receptor degradation and promotes VSMC proliferation., PMID:25814676
Cyclic nucleotide phosphodiesterase-1C (PDE1C) drives cell proliferation, migration and invasion in glioblastoma multiforme cells in vitro., PMID:25620587
Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia., PMID:25608528
Phosphodiesterase isoenzymes in the human urethra: a molecular biology and functional study., PMID:25160741
For research use only. Not for human or drug use.
