Catalog No.
YHG70701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Tyr37-Asp193
Predicted molecular weight
19.47 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14116
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IFN-gamma-inducing factor, IL1F4, Interleukin-1 gamma, IL-18, IL-1 gamma, Interleukin-18, Interferon gamma-inducing factor, IGIF, IL18, Iboctadekin
Diagnostic utility of IL-18 plasma levels in distinguishing abdominal from non-abdominal sepsis., PMID:40510342
Alternative Combinations of IL17A Polymorphic Variants with the Variants of TNF, IL1B, IL6, and IL8 Proinflammatory Cytokines Genes in Uterine Leiomyoma., PMID:40448881
The Potential Contribution of the IL-37/IL-18/IL-18BP/IL-18R Axis in the Pathogenesis of Sjögren's Syndrome., PMID:40430016
Gasdermin-D pores induce an inactivating caspase-4 cleavage that limits IL-18 production in the intestinal epithelium., PMID:40355718
Elevated Plasma Levels of NET Components in Men with Severe COVID-19 Correlates to Increased Amounts of IL-18., PMID:40346759
Elevated serum levels of interleukin-18 discriminate Still's disease from other autoinflammatory conditions: results from the European ImmunAID cohort., PMID:40341183
Basal and exercise-induced expression of NLRP3 inflammasome-related components is increased in patients with chronic coronary syndrome., PMID:40339359
Pentraxin 3 promotes the expression of pro-inflammatory cytokines and the migration of macrophages in myocarditis., PMID:40335910
Evaluation of blood components and their association with Interleukin-18 in chronic myeloid leukemia., PMID:40285781
The critical immunoregulatory roles and molecular mechanisms of IL-10 and IL-18 genes in pneumonia and sepsis., PMID:40258759
Roles of Serum NLRP3 Inflammasome and Associated Cytokines in Gout-Induced Kidney Injury., PMID:40258359
Salivary Interleukin-6 and Interleukin-18 Levels and Their Association with Dental Health in Children with Idiopathic Nephrotic Syndrome., PMID:40243946
Perspective Exploring Novel Associations of IL-18 Levels as a Mediator of the Causal Links between Major Depression and Reproductive Health., PMID:40226698
Serum interleukin-18 levels are specifically elevated in auto-inflammatory diseases involving the pyrin inflammasome: A study on 516 patients., PMID:40204564
CXCL9 and IL-18: potential biomarkers for efficacy evaluation in refractory hemophagocytic lymphohistiocytosis treated with RED (ruxolitinib, emapalumab and dexamethasone)., PMID:40186662
The study of miR-130a expression and its mechanism of action in peripheral blood endothelial progenitor cells (EPCs) in type 2 diabetes mellitus (T2DM)., PMID:40169737
Significant association of functional variants in the promoter sequence of IL18 with disease susceptibility and systemic lupus erythematosus clinical parameters., PMID:40155321
Expression of interleukin-18 in primary Sjögren syndrome and its potential mechanisms with disease: A systematic review and meta-analysis., PMID:40128067
The effect of inflammatory proteins on COVID-19 is mediated by blood metabolites: A Mendelian randomization study., PMID:40101060
The blood biomarker combination IL-8/IL-33 and IL-18/IL-33 distinguish between active tuberculosis and latent infection., PMID:40095362
Escherichia Coli K1-colibactin meningitis induces microglial NLRP3/IL-18 exacerbating H3K4me3-synucleinopathy in human inflammatory gut-brain axis., PMID:40050667
Elevated Plasma Interleukin-18 Levels in Head and Neck Squamous Cell Carcinoma: Correlation With IL-18 Binding Protein But Not Ferritin., PMID:40037860
Circulating hs-CRP, IL-18, Chemerin, Leptin, and Adiponectin Levels Reflect Cardiometabolic Dysfunction in Adults with Excess Weight., PMID:39940942
miR-451a and IL18 can differentiate familial Mediterranean fever patients in attack and remission periods: a prospective cross-sectional study., PMID:39934489
Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to suppress tumor growth., PMID:39891018
Free Interleukin 18 (IL-18F) Blood Levels Following Midline Laparotomy: A Prospective Randomized Study of Patients With Benign Disease and Patients With Cancer., PMID:39890196
Replication Study and Meta-Analysis of the Contribution of Seven Genetic Polymorphisms in Immune-Related Genes to the Risk of Gastric and Colorectal Cancers., PMID:39800859
IL-18 and IL-18BP: A Unique Dyad in Health and Disease., PMID:39769266
Cytokine Gene Variants as Predisposing Factors for the Development and Progression of Coronary Artery Disease: A Systematic Review., PMID:39766338
The role of inflammasome dysregulation in obstructive and non-obstructive azoospermia: a comparative molecular analysis of blood, tissue, and seminal plasma., PMID:39712014
Upregulation of Peripheral Blood NLRP3 and IL-18 in Patients With Acute Kidney Injury in Sepsis and Its Clinical Significance., PMID:39692606
Role of Non-Binding T63 Alteration in IL-18 Binding., PMID:39684709
Correlation of IL-10 and IL18 with the development of liver cirrhosis associated with hepatitis B virus infection: A systematic review., PMID:39671883
Decoy-resistant IL-18 reshapes the tumor microenvironment and enhances rejection by anti-CTLA-4 in renal cell carcinoma., PMID:39561007
Ethanol modulates astrocyte activation and neuroinflammation via miR-339/NLRP6 inflammasome signaling., PMID:39522566
IL-9 sensitizes human TH2 cells to proinflammatory IL-18 signals in atopic dermatitis., PMID:39521283
A carbamazepine metabolite activates NLRP3 and controls skin homing of CD8+ T-cells in SJS/TEN., PMID:39500682
Elevated levels of peripheral and central nervous system immune markers reflect innate immune dysregulation in autism spectrum disorder., PMID:39481220
Impact of HHIP gene polymorphisms on phenotypes, serum IL-17 and IL-18 in COPD patients of the Chinese Han population., PMID:39468530
Role of interleukin-18 in mediating the impacts of celiac disease on osteoporosis: a Mendelian randomization study., PMID:39445015
Evaluation of serum IL 18 / IL 18 binding protein ratio and their relation with IL- 18 gene polymorphisms in sample of Iraqi type 2 diabetes mellitus patients. A case control study., PMID:39434299
Host cytokine genetic polymorphisms in a selected population of persons living with hepatitis B virus infection in the central region of Ghana., PMID:39434005
Key genes and immune pathways in T-cell mediated rejection post-liver transplantation identified via integrated RNA-seq and machine learning., PMID:39414868
Changes in Innate Immunity and Microbiome in Different Aging Phenotypes., PMID:39340620
Vascular Cytokines and Atherosclerosis: Differential Serum Levels of TRAIL, IL-18, and OPG in Obstructive Coronary Artery Disease., PMID:39334884
The Effect of Monobenzone Cream on Oxidative Stress and Its Relationship With Serum Levels of IL-1β and IL-18 in Vitiligo Patients., PMID:39313936
ACSL6-activated IL-18R1-NF-κB promotes IL-18-mediated tumor immune evasion and tumor progression., PMID:39292786
Interleukin-1 family cytokines and soluble receptors in hidradenitis suppurativa., PMID:39278731
Eupafolin hinders cross-talk between gastric cancer cells and cancer-associated fibroblasts by abrogating the IL18/IL18RAP signaling axis., PMID:39265444
IL-10 and IL-18: Key players in liver damage associated with hepatitis A virus infection., PMID:39240632
For research use only. Not for human or drug use.
