Catalog No.
YHF09901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln369-Arg478
Predicted molecular weight
14.73 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P55107
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.01% SKL, 5% Trehalose.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Growth/differentiation factor 10, GDF-10, GDF10, Bone morphogenetic protein 3B, BIP, Bone-inducing protein, BMP3B, BMP-3B
Note
For research use only.
The nuclear receptor REV-ERBα represses the transcription of growth/differentiation factor 10 and 15 genes in rat endometrium stromal cells., PMID:26811051
Optogenetic modulation in stroke recovery., PMID:27132527
A Systems View of the Differences between APOE ε4 Carriers and Non-carriers in Alzheimer's Disease., PMID:27462267
Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme., PMID:28106042
Decrease of growth and differentiation factor 10 contributes to neuropathic pain through N-methyl-D-aspartate receptor activation., PMID:28394782
Perturbations to lysyl oxidase expression broadly influence the transcriptome of lung fibroblasts., PMID:28698228
Treatment with albumin-hydroxyoleic acid complex restores sensorimotor function in rats with spinal cord injury: Efficacy and gene expression regulation., PMID:29244816
A demonstration of the H3 trimethylation ChIP-seq analysis of galline follicular mesenchymal cells and male germ cells., PMID:29381903
Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII-p38MAPK-pS249/T252RB Pathway., PMID:29514796
The caudo-ventral pallium is a novel pallial domain expressing Gdf10 and generating Ebf3-positive neurons of the medial amygdala., PMID:29869132
3D printed titanium cages combined with the Masquelet technique for the reconstruction of segmental femoral defects: Preliminary clinical results and molecular analysis of the biological activity of human-induced membranes., PMID:33937652
RNA Profiling of the Human and Mouse Spinal Cord Stem Cell Niches Reveals an Embryonic-like Regionalization with MSX1+ Roof-Plate-Derived Cells., PMID:31031189
GDF10 inhibits proliferation and epithelial-mesenchymal transition in triple-negative breast cancer via upregulation of Smad7., PMID:31147529
GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury., PMID:31288993
EPO promotes axonal sprouting via upregulating GDF10., PMID:31381959
Axonal sprouting in the dorsal cochlear nucleus affects gap‑prepulse inhibition following noise exposure., PMID:31432095
Spa therapy induces clinical improvement and protein changes in patients with chronic back pain., PMID:31649376
Klf14 is an imprinted transcription factor that regulates placental growth., PMID:31675530
Deep Transcriptomic Analysis Reveals the Dynamic Developmental Progression during Early Development of Channel Catfish (Ictalurus punctatus)., PMID:32748829
Long noncoding RNA ZFPM2-AS1 acts as a miRNA sponge and promotes cell invasion through regulation of miR-139/GDF10 in hepatocellular carcinoma., PMID:32795316
Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia., PMID:33170806
PGM5-AS1 impairs miR-587-mediated GDF10 inhibition and abrogates progression of prostate cancer., PMID:33407592
Cancer-associated fibroblasts promote tumor progression by lncRNA-mediated RUNX2/GDF10 signaling in oral squamous cell carcinoma., PMID:33657265
Caspase-1 Inhibition Impacts the Formation of Chondrogenic Nodules, and the Expression of Markers Related to Osteogenic Differentiation and Lipid Metabolism., PMID:34502478
The Prognostic Value of Bone Morphogenetic Proteins and Their Receptors in Lung Adenocarcinoma., PMID:34745928
GDF10 inhibits cell proliferation and epithelial-mesenchymal transition in nasopharyngeal carcinoma by the transforming growth factor-β/Smad and NF-κB pathways., PMID:34922336
Identification of Growth Factors, Cytokines and Mediators Regulated by Artemisia annua L. Polyphenols (pKAL) in HCT116 Colorectal Cancer Cells: TGF-β1 and NGF-β Attenuate pKAL-Induced Anticancer Effects via NF-κB p65 Upregulation., PMID:35163520
Single-Cell Analysis Uncovers Osteoblast Factor Growth Differentiation Factor 10 as Mediator of Vascular Smooth Muscle Cell Phenotypic Modulation Associated with Plaque Rupture in Human Carotid Artery Disease., PMID:35163719
Caspase-8 Deficient Osteoblastic Cells Display Alterations in Non-Apoptotic Pathways., PMID:35372363
USP15 negatively regulates lung cancer progression through the TRAF6-BECN1 signaling axis for autophagy induction., PMID:35422093
BMP3b Is a Novel Antifibrotic Molecule Regulated by Meflin in Lung Fibroblasts., PMID:35728045
WWP2 confers risk to osteoarthritis by affecting cartilage matrix deposition via hypoxia associated genes., PMID:36208715
Immune infiltration patterns and identification of new diagnostic biomarkers GDF10, NCKAP5, and RTKN2 in non-small cell lung cancer., PMID:36628881
Growth differentiation factor 10 induces angiogenesis to promote wound healing in rats with diabetic foot ulcers by activating TGF-β1/Smad3 signaling pathway., PMID:36714584
Ly-6A-Induced Growth Inhibition and Cell Death in a Transformed CD4+ T Cell Line: Role of Tumor Necrosis Factor-α., PMID:36725744
Brown Adipose Tissue and BMP3b Decrease Injury in Cardiac Ischemia-Reperfusion., PMID:37462036
GDF10 is related to obesity as an adipokine derived from subcutaneous adipose tissue., PMID:37529611
Risk factors analysis and survival prediction model establishment of patients with lung adenocarcinoma based on different pyroptosis-related gene subtypes., PMID:38111060
GDF-10 Induces an Inhibitory Effect on Epithelial-Mesenchymal Transition of Laryngeal Cancer via LPR4., PMID:38163971
Reduced plasma GDF10 levels are positively associated with cholesterol impairment and childhood obesity., PMID:38245533
GDF10 and IDO1 as a thyroid cancer prognostic biomarker associated with immune infiltration., PMID:38509876
Diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in Lung Squamous Cell Carcinoma., PMID:38517673
Strategies for arterial graft optimization at the single-cell level., PMID:39195932
AC099850.3 promotes HBV-HCC cell proliferation and invasion through regulating CD276: a novel strategy for sorafenib and immune checkpoint combination therapy., PMID:39217342
GDF10 is a negative regulator of vascular calcification., PMID:39307303
BMP3b regulates bone mass by inhibiting BMP signaling., PMID:39461491
Excessive BMP3b suppresses skeletal muscle differentiation., PMID:39742789
GDF10 promotes rodent cardiomyocyte maturation during the postnatal period., PMID:39909309
Autocrine GDF10 Inhibits Hepatic Stellate Cell Activation via BMPR2/ALK3 Receptor to Prevent Liver Fibrosis., PMID:40125634
GDF10 Regulates Iron-Dependent Lipid Oxidation in Colorectal Cancer Cells Through Interaction With IGF2., PMID:40275117
For research use only. Not for human or drug use.
