Catalog No.
YHF04801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly2-Asp318
Predicted molecular weight
39.08 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P54750
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PDE1A, Cam-PDE 1A, Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, 61 kDa Cam-PDE, hCam-1
Inhibition of phosphodiesterases 1 and 4 prevents myofibroblast transformation in Peyronie's disease., PMID:39716367
Cross-pathway integration of cAMP signals through cGMP and calcium-regulated phosphodiesterases in mouse striatal cholinergic interneurons., PMID:39604216
Investigation of the underlying mechanism of Buyang Huanwu decoction in ischemic stroke by integrating systems pharmacology-proteomics and in vivo experiments., PMID:38580032
Synthesis and Activity Evaluation of Vinpocetine-Derived Indole Alkaloids., PMID:38202595
Metabolism-Related Prognostic Biomarkers, Purine Metabolism and Anti-Tumor Immunity in Colon Adenocarcinoma., PMID:38179743
Role of Phosphodiesterase 1 in the Regulation of Real-Time cGMP Levels and Contractility in Adult Mouse Cardiomyocytes., PMID:38067187
Dysregulated Cyclic Nucleotide Metabolism in Alcohol-Associated Steatohepatitis: Implications for Novel Targeted Therapies., PMID:37887031
Mesenchymal stem cell-derived extracellular vesicles prevent the formation of pulmonary arterial hypertension through a microRNA-200b-dependent mechanism., PMID:37759281
Phosphodiesterase and psychiatric disorders: a two-sample Mendelian randomization study., PMID:37605207
Targeting CaMKK2 Inhibits Actin Cytoskeletal Assembly to Suppress Cancer Metastasis., PMID:37335130
Ca 2+ /Calmodulin Dependent Protein Kinase Kinase-2 (CaMKK2) promotes Protein Kinase G (PKG)-dependent actin cytoskeletal assembly to increase tumor metastasis., PMID:37131673
Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes., PMID:37125963
Single-cell RNA and transcriptome sequencing profiles identify immune-associated key genes in the development of diabetic kidney disease., PMID:37063851
Microvascular Sex- and Age- Dependent Phosphodiesterase Expression., PMID:35822023
Endoplasmic reticulum stress mediates homocysteine-induced hypertrophy of cardiac cells through activation of cyclic nucleotide phosphodiesterase 1C., PMID:35538034
Secondhand smoke affects reproductive functions by altering the mouse testis transcriptome, and leads to select intron retention in Pde1a., PMID:35063792
Potential Molecular Mechanisms and Remdesivir Treatment for Acute Respiratory Syndrome Corona Virus 2 Infection/COVID 19 Through RNA Sequencing and Bioinformatics Analysis., PMID:34992355
Cardiac Phosphodiesterases Are Differentially Increased in Diabetic Cardiomyopathy., PMID:34339715
Expression of Phosphodiesterase (PDE) Isoenzymes in the Human Male and Female Urethra., PMID:33777854
Airway Ciliary Beating Affected by the Pcp4 Dose-Dependent [Ca2+]i Increase in Down Syndrome Mice, Ts1Rhr., PMID:32178446
Synthesis and biological evaluation of Vinpocetine derivatives., PMID:31859156
PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy., PMID:31131329
Acute Enhancement of Cardiac Function by Phosphodiesterase Type 1 Inhibition., PMID:30030415
Can results from a Japanese pulmonary hypertension registry have an impact on Western guidelines?, PMID:29764745
Seihai-to (TJ-90)-Induced Activation of Airway Ciliary Beatings of Mice: Ca2+ Modulation of cAMP-Stimulated Ciliary Beatings via PDE1., PMID:29495403
[Ca2+ ]i modulation of cAMP-stimulated ciliary beat frequency via PDE1 in airway ciliary cells of mice., PMID:29282782
PDE1A polymorphism contributes to the susceptibility of nephrolithiasis., PMID:29262781
PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β2-Adrenergic Receptors and Adenylyl Cyclase 6., PMID:29262264
A genome-wide association analysis identifies PDE1A|DNAJC10 locus on chromosome 2 associated with idiopathic pulmonary arterial hypertension in a Japanese population., PMID:29088834
Expression of Genes for Methylxanthine Pathway-Associated Enzymes Accompanied by Sex Steroid Receptor Status Impacts Breast Carcinoma Progression., PMID:28971320
Phosphodiesterase 1: A Unique Drug Target for Degenerative Diseases and Cognitive Dysfunction., PMID:28956339
PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries., PMID:28910498
Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells., PMID:28904388
MiR-541-5p regulates lung fibrosis by targeting cyclic nucleotide phosphodiesterase 1A., PMID:28816543
Generation and phenotypic characterization of Pde1a mutant mice., PMID:28750036
Expression and function of phosphodiesterases (PDEs) in the rat urinary bladder., PMID:28687079
Molecular genetic characterization of a prenatally detected de novo interstitial deletion of chromosome 2q (2q31.1-q32.1) encompassing HOXD13, ZNF385B and ZNF804A associated with syndactyly and increased first-trimester nuchal translucency., PMID:28600059
Novel selective PDE type 1 inhibitors cause vasodilatation and lower blood pressure in rats., PMID:28548283
A low [Ca2+]i-induced enhancement of cAMP-activated ciliary beating by PDE1A inhibition in mouse airway cilia., PMID:28477148
Effect of Shenmai injection on preventing the development of nitroglycerin-induced tolerance in rats., PMID:28453571
Influence of cell confluence on the cAMP signalling pathway in vascular smooth muscle cells., PMID:28389413
Ca(2+)/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function., PMID:27363295
Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats., PMID:27342643
RNA-binding protein CUGBP1 regulates insulin secretion via activation of phosphodiesterase 3B in mice., PMID:27255754
Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis., PMID:27009040
A novel PDE1A coupled to M2AChR at plasma membranes from bovine tracheal smooth muscle., PMID:26513204
Phosphodiesterase 1 regulation is a key mechanism in vascular aging., PMID:26464516
Cyclic nucleotide phosphodiesterase 1 and vascular aging., PMID:26374857
Modulation of Polycystic Kidney Disease Severity by Phosphodiesterase 1 and 3 Subfamilies., PMID:26374610
Expression and distribution of phosphodiesterase isoenzymes in the human male urethra., PMID:25704994
For research use only. Not for human or drug use.
