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Research Grade Gevokizumab (DHB95602)

Host species:Humanized
Isotype:IgG2-kappa
Applications:Research Grade Biosimilar
Expression system:Mammalian Cells
Overview

Catalog No.

DHB95602

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG2-kappa

Clonality

Monoclonal

Target

Interleukin-1 beta, IL1B, Catabolin, IL1F2, IL-1 beta

Concentration

1.31 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P01584

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

XOMA 052, CAS: 1129435-60-4

Clone ID

Gevokizumab

Data Image
  • Bioactivity
    Detects Human IL1B/IL1F2 in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Gevokizumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

Antibodies to watch in 2014, PMID: 24284914

Antibodies to watch in 2015, PMID: 25484055

Antibodies to watch in 2016, PMID: 26651519

Anti-cytokine biologic treatment beyond anti-TNF in Behçet's disease, PMID: 25268669

Biologic therapy for Behçet's uveitis: a systematic review, PMID: 31676596

Biological treatments in Behçet's disease: beyond anti-TNF therapy, PMID: 25061259

Biologics in the treatment of pustular psoriasis, PMID: 32615817

Blocking interleukin-1 as a novel therapeutic strategy for secondary prevention of cardiovascular events, PMID: 22571369

Cooling down inflammation in type 2 diabetes: how strong is the evidence for cardiometabolic benefit?, PMID: 27230767

Current and future treatments for Behçet's uveitis: road to remission, PMID: 23729309

Currently Used Biologic Agents in the Management of Behcet's Syndrome, PMID: 25666786

Cytokines of the IL-1 family: recognized targets in chronic inflammation underrated in organ transplantations, PMID: 28798075

Detailed mechanistic analysis of gevokizumab, an allosteric anti-IL-1β antibody with differential receptor-modulating properties, PMID: 24194526

Effect of Gevokizumab on Interleukin-1β-Mediated Cytochrome P450 3A4 and Drug Transporter Repression in Cultured Human Hepatocytes, PMID: 28260174

Effectiveness and tuberculosis-related safety profile of interleukin-1 blocking agents in the management of Behçet's disease, PMID: 25151975

Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes, PMID: 22699287

Emerging therapies for noninfectious uveitis: what may be coming to the clinics, PMID: 24868451

Gevokizumab in the Treatment of Autoimmune Non-necrotizing Anterior Scleritis: Results of a Phase I/II Clinical Trial, PMID: 27663070

Gevokizumab in type 1 diabetes mellitus: extreme remedies for extreme diseases?, PMID: 25079039

Gevokizumab, an anti-IL-1β mAb for the potential treatment of type 1 and 2 diabetes, rheumatoid arthritis and cardiovascular disease, PMID: 21154167

Giant Cell Arteritis: Beyond Corticosteroids, PMID: 26239828

Horizon 2020 in Diabetic Kidney Disease: The Clinical Trial Pipeline for Add-On Therapies on Top of Renin Angiotensin System Blockade, PMID: 26239562

IL-1 Inhibitors in the Treatment of Monogenic Periodic Fever Syndromes: From the Past to the Future Perspectives, PMID: 33603750

IL-1β Inhibition in Cardiovascular Complications Associated to Diabetes Mellitus, PMID: 28659798

Inflammasome and cytokine blocking strategies in autoinflammatory disorders, PMID: 23697917

Inhibition of Interleukin-1 in the Treatment of Selected Cardiovascular Complications, PMID: 32674739

Interleukin-1 antagonism in type 1 diabetes of long duration, PMID: 27720360

Interleukin-1 blockade in cardiovascular diseases: a clinical update, PMID: 29584915

Interleukin-1 Blockade in Polygenic Autoinflammatory Disorders: Where Are We now?, PMID: 33708123

Interleukin-1 blockade treatment decreasing cardiovascular risk, PMID: 31415103

Interleukin-1β-regulating antibody XOMA 052 (gevokizumab) in the treatment of acute exacerbations of resistant uveitis of Behcet's disease: an open-label pilot study, PMID: 22084392

Molecule of the month. XOMA-052, PMID: 20016858

One target-two different binding modes: structural insights into gevokizumab and canakinumab interactions to interleukin-1β, PMID: 23041424

One year in review 2016: Behçet's syndrome, PMID: 27791958

Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases, PMID: 28588486

Rheumatoid Arthritis Associated Episcleritis and Scleritis: An Update on Treatment Perspectives, PMID: 34068884

Safety and Efficacy of Gevokizumab in Patients with Behçet's Disease Uveitis: Results of an Exploratory Phase 2 Study, PMID: 26829647

Targeting inflammation in diabetic kidney disease: early clinical trials, PMID: 27268955

Targeting Interleukin-1 beta to Suppress Sympathoexcitation in Hypothalamic Paraventricular Nucleus in Dahl Salt-Sensitive Hypertensive Rats, PMID: 26304161

The challenge of autoinflammatory syndromes: with an emphasis on hyper-IgD syndrome, PMID: 27856657

The IL-1β Antibody Gevokizumab Limits Cardiac Remodeling and Coronary Dysfunction in Rats With Heart Failure, PMID: 30062160

The interleukin-1β modulator gevokizumab reduces neointimal proliferation and improves reendothelialization in a rat carotid denudation model, PMID: 25108619

The right place of interleukin-1 inhibitors in the treatment of Behçet's syndrome: a systematic review, PMID: 30799530

The Use of Biologic Therapies in Uveitis, PMID: 25431348

Treatment of Inflammatory Diseases with IL-1 Blockade, PMID: 33133777

Treatment of two patients with generalized pustular psoriasis with the interleukin-1β inhibitor gevokizumab, PMID: 25495649

Update on the use of systemic biologic agents in the treatment of noninfectious uveitis, PMID: 24600203

Use of Gevokizumab in Patients with Behçet's Disease Uveitis: An International, Randomized, Double-Masked, Placebo-Controlled Study and Open-Label Extension Study, PMID: 29370572

Which are the antibodies to watch in 2013?, PMID: 23254906

XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1β-mediated diseases, PMID: 21048425

Datasheet

Document Download

Research Grade Gevokizumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

Contact Information

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Distributor list

For research use only. Not for human or drug use.

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Research Grade Gevokizumab [DHB95602]
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