Catalog No.
YHE22001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ala140
Predicted molecular weight
16.77 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P37840
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Alpha-synuclein, PARK1, Non-A4 component of amyloid precursor, NACP, Non-A beta component of AD amyloid, SNCA
Vimentin network dysregulation mediates neurite deficits in SNCA duplication Parkinson's patient-derived midbrain neurons., PMID:40479066
GATA Transcription Factors: A Cross-Road for Erythropoiesis, Neurodevelopment, and Synucleinopathies., PMID:40474753
Variants in Lrrk2 and Snca deficiency do not alter the course of primary encephalitis due to neurotropic reovirus T3D in newborn mice., PMID:40471880
Generation of iPSC lines with tagged α-synuclein for visualization of endogenous protein in human cellular models of neurodegenerative disorders., PMID:40456614
circ_0005654 as a Sponge of the miR-588 Dual Pathway to Promote α-Synuclein Expression., PMID:40444442
Imbalanced mitochondrial dynamics in human PD and α-synuclein mouse brains., PMID:40436283
The Role of N6-Methyladenosine (m6A) RNA Modification in the Pathogenesis of Parkinson's Disease., PMID:40427510
Systematic identification of SNCA as a key gene in ischemic cardiomyopathy via integrated weighted gene co-expression network analysis and experimental validation., PMID:40414013
The molecular basis of music-induced neuroplasticity in humans: A systematic review., PMID:40412457
Experimental and computational insights into the therapeutic mechanisms of resveratrol in a Drosophila α-synuclein model of Parkinson's disease., PMID:40404673
Neuronal activity triggers secretory autophagy to mediate the extracellular release of SNCA/α-synuclein., PMID:40395520
Exploring α-Syn's Functions Through Ablation Models: Physiological and Pathological Implications., PMID:40389720
ZSCAN21 mediates the pathogenic transcriptional induction of α-synuclein in cellular and animal models of Parkinson's disease., PMID:40379611
MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson's disease., PMID:40367191
Identification of Hub Genes and Key Pathways Associated with Sepsis Progression Using Weighted Gene Co-Expression Network Analysis and Machine Learning., PMID:40362669
Neurogrit Gold Attenuates 6-OHDA-Induced Dopaminergic Neurodegeneration in Parkinson's Model of Caenorhabditis elegans by Reducing α-Synuclein Accumulation and Pink/Pdr-1 Driven Mitochondrial Dysfunction., PMID:40342222
Structural and functional insights into the nuclear role of Parkinson's disease-associated α-synuclein as a histone chaperone., PMID:40341765
Combined assessment of blood glucocerebrosidase activity and α-synuclein levels in GBA1 mutation carriers: A novel potential biomarker., PMID:40339261
Oligodendrocyte-specific overexpression of human alpha-synuclein results in elevated MBP levels and inflammatory responses in TgM83 mice, mimicking the pathological features of multiple system atrophy., PMID:40336104
GWAS by Subtraction to Disentangle RBD Genetic Background from α-Synucleinopathies., PMID:40332088
Peripheral Immune pattern in a genetic cohort of p.A53T alpha-synuclein carriers., PMID:40328209
Mechanistic insights into Alpha-Synuclein binding to P2RX7: A molecular dynamic and docking study., PMID:40315262
Widespread distribution of α-synuclein oligomers in LRRK2-related Parkinson's disease., PMID:40314842
The Nuclear Transitory Zone: A Key Player in the Cerebellar Development., PMID:40314748
Defining essential charged residues in fibril formation of a lysosomal derived N-terminal α-synuclein truncation., PMID:40268916
Development of In Vitro Parkinson's Disease Model Mediated by MPP+ and α-Synuclein Using Wharton's Jelly Mesenchymal Stem Cells., PMID:40260646
Randomization based evaluation of distinct topological and cancer expression characteristics of mutually acting gene pairs., PMID:40257012
A ROS-Responsive nanoparticle for nuclear gene delivery and autophagy restoration in Parkinson's disease therapy., PMID:40245457
The potential of erythrocyte α-synuclein to differentiate dementia with Lewy bodies from Parkinson's and Alzheimer's diseases., PMID:40235217
Linking Parkinson's disease and melanoma: the impact of copper-driven cuproptosis and related mechanisms., PMID:40221422
Apigenin enhances Nrf2-induced chaperone-mediated autophagy and mitigates α-synuclein pathology: Implications for Parkinson's disease therapy., PMID:40215824
Skin α-synuclein assays in diagnosing Parkinson's disease: a systematic review and meta-analysis., PMID:40205187
A fragment of Calpain-1 cleaved α-Synuclein quantified in serum is upregulated in patients with Parkinson's disease., PMID:40204767
Plasma and urinary metabolomic signatures differentiate genetic and idiopathic Parkinson's disease., PMID:40204143
Myeloid FtH Regulates Macrophage Response to Kidney Injury by Modulating Snca and Ferroptosis., PMID:40196511
Alpha-synuclein knockout impairs melanoma development and alters DNA damage repair in the TG3 mouse model in a sex-dependent manner., PMID:40182046
Genetic variants associated with idiopathic Parkinson's disease in Latin America: A systematic review., PMID:40178685
Alpha-Synuclein Phosphomimetic Y39E and S129D Knock-In Mice Show Cytosolic Alpha-Synuclein Localization without Developing Neurodegeneration or Motor Deficits., PMID:40164505
R406 and its structural analogs reduce SNCA/α-synuclein levels via autophagic degradation., PMID:40143425
Next Generation Sequencing Analysis in Patients Affected by Parkinson's Disease and Correlation Between Genotype and Phenotype in Selected Clinical Cases., PMID:40141040
Alpha-Synuclein Pathophysiology in Neurodegenerative Disorders: A Review Focusing on Molecular Mechanisms and Treatment Advances in Parkinson's Disease., PMID:40140103
Identical Seeding Characteristics and Cryo-EM Filament Structures in FTLD-Synuclein and Typical Multiple System Atrophy., PMID:40135351
α7-Nicotinic Acetylcholine Receptor and Mutated α-Synuclein Interact in Motor Behaviour and Nigrostriatal Dopamine-Findings With Potential Relevance for a Protective Effect of Cigarette Smoking and Parkinson's Disease., PMID:40125558
Recent developments in gene therapy for Parkinson's disease., PMID:40121531
Polyoxometalates bind multiple targets involved in Alzheimer's disease., PMID:40119889
Differential gene expression patterns in Niemann-Pick Type C and Tay-Sachs diseases: Implications for neurodegenerative mechanisms., PMID:40106490
Leptin as a potential neuroprotective target in Parkinson's Disease: Exploring its role in Neuroinflammation, oxidative Stress, and dopaminergic neurodegeneration., PMID:40064367
Haploinsufficiency of ITSN1 is associated with a substantial increased risk of Parkinson's disease., PMID:40056900
Alpha-synuclein expression in anterior pituitary cells of aged cattle., PMID:40054104
For research use only. Not for human or drug use.
