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Anti-MTDH Antibody (R4A58)

Catalog #:   RHN88904 Specific References (22) DATASHEET
Host species: Mouse
Isotype: IgG1
Applications: ELISA, FCM, IHC, WB
Accession: Q86UE4
Overview

Catalog No.

RHN88904

Species reactivity

Human, Monkey

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

ELISA: 1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000, WB: 1:500-1:2000

Target

3D3/LYRIC, AEG1, LYRIC, AEG-1, MTDH, Lysine-rich CEACAM1 co-isolated protein, Astrocyte elevated gene-1 protein, Protein LYRIC, Metadherin, Metastasis adhesion protein

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q86UE4

Applications

ELISA, FCM, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R4A58

Data Image
  • Flow Cytometry
    Flow cytometric analysis of Hela cells using MTDH mouse mAb (green) and negative control (red).
  • Immunohistochemical
    Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using MTDH mouse mAb with DAB staining.
  • Immunohistochemical
    Immunohistochemical analysis of paraffin-embedded human prostate cancer tissues using MTDH mouse mAb with DAB staining.
  • Western blot
    Western blot analysis using MTDH mouse mAb against MCF-7 (1), T47D (2), Jurkat(3), K562 (4), Hela (5),PC-3 (6), HepG2(7), A431(8) and COS7 (9) cell lysate.
References

Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH): A Promising Molecular Marker and Therapeutic Target for Hepatocellular Carcinoma., PMID:40282551

MTDH antisense oligonucleotides reshape the immunosuppressive tumor microenvironment to sensitize Hepatocellular Carcinoma to immune checkpoint blockade therapy., PMID:35609735

Metadherin (AEG-1/MTDH/LYRIC) expression: Significance in malignancy and crucial role in colorectal cancer., PMID:35152973

Elevated expression of MTDH predicts better prognosis of locally advanced HER-2 positive breast cancer patients receiving neoadjuvant chemotherapy plus trastuzumab., PMID:31490377

miR-217 suppresses proliferation, migration, and invasion promoting apoptosis via targeting MTDH in hepatocellular carcinoma., PMID:28184926

[Preparation and application of mouse anti-AEG-1 monoclonal antibody]., PMID:27916103

Bonafide Targets of Deregulated microRNAs in Non-Small Cell Lung Cancer as Tool to Identify Novel Therapeutic Targets: A Review., PMID:27719642

IL-8 interacts with metadherin promoting proliferation and migration in gastric cancer., PMID:27565732

AEG-1 activates Wnt/PCP signaling to promote metastasis in tongue squamous cell carcinoma., PMID:26689985

Immunohistochemistry-based prognostic biomarkers in NSCLC: novel findings on the road to clinical use?, PMID:25599124

MTDH mediates trastuzumab resistance in HER2 positive breast cancer by decreasing PTEN expression through an NFκB-dependent pathway., PMID:25417825

AEG-1/MTDH/LYRIC: clinical significance., PMID:23889987

Identification of cell surface proteins as potential immunotherapy targets in 12 pediatric cancers., PMID:23251904

Prognostic impact of Metadherin-SND1 interaction in colon cancer., PMID:23065261

Gold nanoparticle probes: design and in vitro applications in cancer cell culture., PMID:22070896

Molecular mimicry of human endothelial cell antigen by autoantibodies to nonstructural protein 1 of dengue virus., PMID:21233208

Expression patterns of astrocyte elevated gene-1 (AEG-1) during development of the mouse embryo., PMID:20736086

A new approach for in vitro imaging of breast cancer cells by anti-metadherin targeted PVA-pyrene., PMID:20336700

Alternaria alternata NADP-dependent mannitol dehydrogenase is an important fungal allergen., PMID:17177674

Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1., PMID:15927426

Metadherin, a cell surface protein in breast tumors that mediates lung metastasis., PMID:15093543

3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus., PMID:14980505

Datasheet

Document Download

Anti-MTDH Antibody (R4A58).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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For research use only. Not for human or drug use.

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Anti-MTDH Antibody (R4A58) [RHN88904]
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