Catalog No.
RHH18903
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000
Target
DNAX accessory molecule 1, DNAM-1, DNAM1, CD226 antigen, CD226
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q15762
Applications
ELISA, FCM, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3U02
Impact of immune checkpoint TIGIT on the activation and function of natural killer cells in rheumatoid arthritis patients., PMID:40465407
Novel diagnostic biomarker and immune profiling of GPR56+ B cell subsets in systemic lupus erythematosus., PMID:40311320
T-cell immunoglobulin and ITIM domain as a target in combo anti-PD-(L)1 cancer therapy., PMID:40294684
Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway., PMID:40049088
Mapping the nanoscale organization of the human cell surface proteome reveals new functional associations and surface antigen clusters., PMID:40027624
Fc-competent TIGITx4-1BB bispecific antibody exerts potent long-lasting antitumor activity by potentiating CD8+ T cell activity and Fcγ receptor-mediated modulation of the tumor microenvironment., PMID:40010766
Antitumor effects of natural killer cells derived from gene-engineered human-induced pluripotent stem cells on hepatocellular carcinoma., PMID:39904787
CD226 + adipose tissue macrophages arise from MDP-derived monocytes and regulate lipid metabolism., PMID:39677815
Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function., PMID:39636437
Salvianolic acid B improves the microcirculation in a mouse model of sepsis through a mechanism involving the platelet receptor CD226., PMID:39443080
Integrated Transcriptomic Analysis Reveals Reciprocal Interactions between SARS-CoV-2 Infection and Multi-Organ Dysfunction, Especially the Correlation of Renal Failure and COVID-19., PMID:39202702
Clinical response and pathway-specific correlates following TIGIT-LAG3 blockade in myeloma: the MyCheckpoint randomized clinical trial., PMID:39187595
Inhibition of CD226 Co-Stimulation Suppresses Diabetes Development in the NOD Mouse by Augmenting Tregs and Diminishing Effector T Cell Function., PMID:39071293
A novel enzyme-linked immunosorbent assay tool to evaluate plasma soluble CD226 in primary Sjögren's syndrome., PMID:38768695
Fc-Silent Anti-TIGIT Antibodies Potentiate Antitumor Immunity without Depleting Regulatory T Cells., PMID:38635895
TIGIT acts as an immune checkpoint upon inhibition of PD1 signaling in autoimmune diabetes., PMID:38533515
Altered CD226/TIGIT expressions were associated with NK phenotypes in primary antiphospholipid syndrome and affected by IL-4/JAK pathway., PMID:38386917
Harnessing the cytotoxic granule exocytosis to augment the efficacy of T-cell-engaging bispecific antibody therapy., PMID:38268493
Blocking CD226 regulates type 2 innate lymphoid cell effector function and alleviates airway hyperreactivity., PMID:38244725
Poliovirus receptor inhibition in breast cancer cells induces antitumor immunity via T cell activation., PMID:38187056
Biomarkers in the Pathogenesis, Diagnosis, and Treatment of Systemic Sclerosis., PMID:37868834
Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT., PMID:37675979
Combined Blockade of TIGIT and PD-L1 Enhances Anti-Neuroblastoma Efficacy of GD2-Directed Immunotherapy with Dinutuximab Beta., PMID:37444427
The apoptotic effects of NK-92 cells stimulated with an anti-CD226 antibody on MDA-MB-231 triple-negative breast cancer cells., PMID:37410214
The IgV domain of the poliovirus receptor alone is immunosuppressive and binds to its receptors with comparable affinity., PMID:36944702
CD226 deficiency exacerbated intestinal immune dysregulation in mice with dinitrochlorobenzene-induced atopic dermatitis., PMID:36938934
Costimulatory CD226 Signaling Regulates Proliferation of Memory-like NK Cells in Healthy Individuals with Latent Mycobacterium tuberculosis Infection., PMID:36361628
CD8+ and CD8- NKT Cells Exhibit Phenotypic Changes During Pregnancy., PMID:36102790
Biomarkers of disease activity in dermatomyositis., PMID:36082751
Fcγ receptor-mediated cross-linking codefines the immunostimulatory activity of anti-human CD96 antibodies., PMID:35998045
Inflammatory Cytokine-Neutralizing Antibody Treatment Prevented Increases in Follicular Helper T Cells and Follicular Regulatory T Cells in a Mouse Model of Arthritis., PMID:35860232
Emergence of the CD226 Axis in Cancer Immunotherapy., PMID:35812451
Non-HLA Gene Polymorphisms in the Pathogenesis of Type 1 Diabetes: Phase and Endotype Specific Effects., PMID:35812428
The Ratio of CD226 and TIGIT Expression in Tfh and PD-1+ICOS+Tfh Cells Are Potential Biomarkers for Chronic Antibody-Mediated Rejection in Kidney Transplantation., PMID:35733922
Pregnancy enables antibody protection against intracellular infection., PMID:35676476
Blockade of inhibitory killer cell immunoglobulin-like receptors and IL-2 triggering reverses the functional hypoactivity of tumor-derived NK-cells in glioblastomas., PMID:35474089
Changes in the natural killer cell repertoire and function induced by the cancer immune adjuvant candidate IMMUNEPOTENT-CRP., PMID:35381435
TIGIT-CD226-PVR axis: advancing immune checkpoint blockade for cancer immunotherapy., PMID:35379739
Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses., PMID:35263569
Interacting Genetic Lesions of Melanoma in the Tumor Microenvironment: Defining a Viable Therapy., PMID:34888847
Immune checkpoint molecule TIGIT manipulates T cell dysfunction in septic patients., PMID:34653731
Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus., PMID:34373559
Increased Proportion of CD226+ B Cells Is Associated With the Disease Activity and Prognosis of Systemic Lupus Erythematosus., PMID:34367178
TIGIT, the Next Step Towards Successful Combination Immune Checkpoint Therapy in Cancer., PMID:34367161
Cytokine-enhanced cytolytic activity of exosomes from NK Cells., PMID:34316033
Suppression of Th1 and Th17 Proinflammatory Cytokines and Upregulation of FOXP3 Expression by a Humanized Anti-DNAM-1 Monoclonal Antibody., PMID:33900821
Altered follicular regulatory T (Tfr)- and helper T (Tfh)-cell subsets are associated with autoantibody levels in microscopic polyangiitis patients., PMID:33764509
TIGIT/CD226 Axis Regulates Anti-Tumor Immunity., PMID:33670993
Anti-tumour necrosis factor-alpha response associated with combined CD226 and HLA-DRB1[*]0404 haplotype in rheumatoid arthritis., PMID:33427622
Expansion of circulating peripheral TIGIT+CD226+ CD4 T cells with enhanced effector functions in dermatomyositis., PMID:33413573
For research use only. Not for human or drug use.
