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Anti-IRF5 Antibody (R3S81)

Catalog #:   RHG59003 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG2a
Applications: IP, WB
Accession: Q13568
Overview

Catalog No.

RHG59003

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a

Clonality

Monoclonal

Tested applications

IP: 1:100-1:200, WB: 1:500-1:1000

Target

IRF5, Interferon regulatory factor 5, IRF-5

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q13568

Applications

IP, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3S81

Data Image
  • Immunoprecipitation
    Lane 1: THP-1 lysate ; Lane 2: IRF5 immunoprecipitated from THP-1 lysate by RHG59003;Lane 3: The same as Lane 2 but use IgG isotype control antibody ;Result: RHG59003 can immunoprecipitate IRF5;
  • Western blot
    Western blot analysis using IRF5 mouse mAb against THP-1 lysate
References

Systemic Sclerosis and Primary Biliary Cholangitis: A Comprehensive Review of Two Overlapping Rare Entities With Insights on Diagnostics and Management., PMID:40351968

From genetic variants to therapeutic targets: insights into understanding rheumatoid arthritis., PMID:40236704

Transcriptomic signatures in peripheral CD4+T-lymphocytes may reflect melanoma staging and immunotherapy responsiveness prior to ICI initiation., PMID:40226614

Dysregulation of T Follicular Helper and Regulatory Cells in IRF5-SLE Homozygous Risk Carriers and Systemic Lupus Erythematosus Patients., PMID:40136703

Exploring the association between Mycobacterium avium subspecies paratuberculosis infection and rheumatoid arthritis: an immunological perspective., PMID:39985098

IRF5 Controls Plasma Cell Generation and Antibody Production via Distinct Mechanisms Depending on the Antigenic Trigger., PMID:39572974

Trailblazing in adjuvant research: succinate's uncharted territory with neutrophils., PMID:38708521

CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis., PMID:38166463

Cross-reactivity between Mycobacterium avium subspecies paratuberculosis 4027 peptide and Human IRF5 may contribute to Multiple Sclerosis in Iranian patients., PMID:38034802

Biomarkers in Systemic Sclerosis: An Overview., PMID:37886934

Biomarkers in the Pathogenesis, Diagnosis, and Treatment of Systemic Sclerosis., PMID:37868834

Genetic Reduction of IRF5 Expression after Disease Initiation Reduces Disease in a Mouse Lupus Model by Impacting Systemic and End-Organ Pathogenic Pathways., PMID:37721418

Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in CCI-induced Neuropathic Pain in Rats., PMID:37622691

Macrophages in the synovial lining niche initiate neutrophil recruitment and articular inflammation., PMID:37115585

Sex differences in the percentage of IRF5 positive B cells are associated with higher production of TNF-α in women in response to TLR9 in humans., PMID:36814288

Detection of neutrophil extracellular traps in patient plasma: method development and validation in systemic lupus erythematosus and healthy donors that carry IRF5 genetic risk., PMID:35958624

Neutrophils recruited to immunization sites initiating vaccine-induced antibody responses by locally expressing BAFF., PMID:35874922

Th2 to Th1 Transition Is Required for Induction of Skin Lesions in an Inducible and Recurrent Murine Model of Cutaneous Lupus-Like Inflammation., PMID:35833127

Two Conserved Phenylalanine Residues in the E1 Fusion Loop of Alphaviruses Are Essential for Viral Infectivity., PMID:35416719

Seroprevalence of diphtheria and measles antibodies and their association with demographics, self-reported immunity, and immunogenetic factors in healthcare workers in Latvia., PMID:35243323

Early DNA methylation changes in children developing beta cell autoimmunity at a young age., PMID:35142878

Molecular mechanisms controlling age-associated B cells in autoimmunity., PMID:35102602

Elevated mycobacterium avium subsp. paratuberculosis (MAP) antibody titer in Japanese multiple sclerosis., PMID:34507015

The adjuvanticity of manganese for microbial vaccines via activating the IRF5 signaling pathway., PMID:34363796

Abnormalities of the type I interferon signaling pathway in lupus autoimmunity., PMID:34340046

Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease., PMID:34282144

Intracellular IRF5 Dimerization Assay., PMID:34150928

The gene silencing of IRF5 and BLYSS effectively modulates the outcome of experimental lupus nephritis., PMID:33996261

Lipid Receptor G2A-Mediated Signal Pathway Plays a Critical Role in Inflammatory Response by Promoting Classical Macrophage Activation., PMID:33941654

Association of the STAT4, CDKN1A, and IRF5 variants with risk of lupus nephritis and renal biopsy classification in patients in Vietnam., PMID:33687153

Association of Fusobacterium nucleatum with Specific T-cell Subsets in the Colorectal Carcinoma Microenvironment., PMID:33632927

The IKZF1-IRF4/IRF5 Axis Controls Polarization of Myeloma-Associated Macrophages., PMID:33563611

The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells., PMID:33357409

VISTA Re-programs Macrophage Biology Through the Combined Regulation of Tolerance and Anti-inflammatory Pathways., PMID:33178206

Inhibition of IRF5 hyperactivation protects from lupus onset and severity., PMID:32897883

Antibody response to homologous epitopes of Epstein-Barr virus, Mycobacterium avium subsp. paratuberculosis and IRF5 in patients with different connective tissue diseases and in mouse model of antigen-induced arthritis., PMID:32743529

IRF5 Acts as a Potential Therapeutic Marker in Inflammatory Bowel Diseases., PMID:32737976

Dendritic cells' characteristics in patients with treated systemic lupus erythematosus., PMID:32730703

Clinical Management and Therapeutic Strategies for the Thyroid-Associated Ophthalmopathy: Current and Future Perspectives., PMID:32567373

Role of IRF5 in the pathogenesis of immunoglobulin-A vasculitis., PMID:32441646

TRIM21 Dysfunction Enhances Aberrant B-Cell Differentiation in Autoimmune Pathogenesis., PMID:32117252

IRF5 genetic risk variants drive myeloid-specific IRF5 hyperactivation and presymptomatic SLE., PMID:31877114

PtpA and PknG Proteins Secreted by Mycobacterium avium subsp. paratuberculosis are Recognized by Sera from Patients with Rheumatoid Arthritis: A Case-Control Study., PMID:31819587

Modifications of the Transcriptomic Profile of Autoreactive B Cells From Pemphigus Patients After Treatment With Rituximab or a Standard Corticosteroid Regimen., PMID:31440235

A comprehensive review of rituximab therapy in rheumatoid arthritis patients., PMID:31367943

Antiphospholipid syndrome's genetic and epigenetic aspects., PMID:31323355

Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients., PMID:31156624

Irf5 deficiency in myeloid cells prevents necrotizing enterocolitis by inhibiting M1 macrophage polarization., PMID:31086271

Genetic implications in the pathogenesis of rheumatoid arthritis; an updated review., PMID:30904715

The Post-GWAS Era: How to Validate the Contribution of Gene Variants in Lupus., PMID:30673885

Datasheet

Document Download

Anti-IRF5 Antibody (R3S81).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-IRF5 Antibody (R3S81) [RHG59003]
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