Catalog No.
RHG59003
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
IP: 1:100-1:200, WB: 1:500-1:1000
Target
IRF5, Interferon regulatory factor 5, IRF-5
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q13568
Applications
IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3S81
Systemic Sclerosis and Primary Biliary Cholangitis: A Comprehensive Review of Two Overlapping Rare Entities With Insights on Diagnostics and Management., PMID:40351968
From genetic variants to therapeutic targets: insights into understanding rheumatoid arthritis., PMID:40236704
Transcriptomic signatures in peripheral CD4+T-lymphocytes may reflect melanoma staging and immunotherapy responsiveness prior to ICI initiation., PMID:40226614
Dysregulation of T Follicular Helper and Regulatory Cells in IRF5-SLE Homozygous Risk Carriers and Systemic Lupus Erythematosus Patients., PMID:40136703
Exploring the association between Mycobacterium avium subspecies paratuberculosis infection and rheumatoid arthritis: an immunological perspective., PMID:39985098
IRF5 Controls Plasma Cell Generation and Antibody Production via Distinct Mechanisms Depending on the Antigenic Trigger., PMID:39572974
Trailblazing in adjuvant research: succinate's uncharted territory with neutrophils., PMID:38708521
CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis., PMID:38166463
Cross-reactivity between Mycobacterium avium subspecies paratuberculosis 4027 peptide and Human IRF5 may contribute to Multiple Sclerosis in Iranian patients., PMID:38034802
Biomarkers in Systemic Sclerosis: An Overview., PMID:37886934
Biomarkers in the Pathogenesis, Diagnosis, and Treatment of Systemic Sclerosis., PMID:37868834
Genetic Reduction of IRF5 Expression after Disease Initiation Reduces Disease in a Mouse Lupus Model by Impacting Systemic and End-Organ Pathogenic Pathways., PMID:37721418
Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in CCI-induced Neuropathic Pain in Rats., PMID:37622691
Macrophages in the synovial lining niche initiate neutrophil recruitment and articular inflammation., PMID:37115585
Sex differences in the percentage of IRF5 positive B cells are associated with higher production of TNF-α in women in response to TLR9 in humans., PMID:36814288
Detection of neutrophil extracellular traps in patient plasma: method development and validation in systemic lupus erythematosus and healthy donors that carry IRF5 genetic risk., PMID:35958624
Neutrophils recruited to immunization sites initiating vaccine-induced antibody responses by locally expressing BAFF., PMID:35874922
Th2 to Th1 Transition Is Required for Induction of Skin Lesions in an Inducible and Recurrent Murine Model of Cutaneous Lupus-Like Inflammation., PMID:35833127
Two Conserved Phenylalanine Residues in the E1 Fusion Loop of Alphaviruses Are Essential for Viral Infectivity., PMID:35416719
Seroprevalence of diphtheria and measles antibodies and their association with demographics, self-reported immunity, and immunogenetic factors in healthcare workers in Latvia., PMID:35243323
Early DNA methylation changes in children developing beta cell autoimmunity at a young age., PMID:35142878
Molecular mechanisms controlling age-associated B cells in autoimmunity., PMID:35102602
Elevated mycobacterium avium subsp. paratuberculosis (MAP) antibody titer in Japanese multiple sclerosis., PMID:34507015
The adjuvanticity of manganese for microbial vaccines via activating the IRF5 signaling pathway., PMID:34363796
Abnormalities of the type I interferon signaling pathway in lupus autoimmunity., PMID:34340046
Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease., PMID:34282144
Intracellular IRF5 Dimerization Assay., PMID:34150928
The gene silencing of IRF5 and BLYSS effectively modulates the outcome of experimental lupus nephritis., PMID:33996261
Lipid Receptor G2A-Mediated Signal Pathway Plays a Critical Role in Inflammatory Response by Promoting Classical Macrophage Activation., PMID:33941654
Association of the STAT4, CDKN1A, and IRF5 variants with risk of lupus nephritis and renal biopsy classification in patients in Vietnam., PMID:33687153
Association of Fusobacterium nucleatum with Specific T-cell Subsets in the Colorectal Carcinoma Microenvironment., PMID:33632927
The IKZF1-IRF4/IRF5 Axis Controls Polarization of Myeloma-Associated Macrophages., PMID:33563611
The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells., PMID:33357409
VISTA Re-programs Macrophage Biology Through the Combined Regulation of Tolerance and Anti-inflammatory Pathways., PMID:33178206
Inhibition of IRF5 hyperactivation protects from lupus onset and severity., PMID:32897883
Antibody response to homologous epitopes of Epstein-Barr virus, Mycobacterium avium subsp. paratuberculosis and IRF5 in patients with different connective tissue diseases and in mouse model of antigen-induced arthritis., PMID:32743529
IRF5 Acts as a Potential Therapeutic Marker in Inflammatory Bowel Diseases., PMID:32737976
Dendritic cells' characteristics in patients with treated systemic lupus erythematosus., PMID:32730703
Clinical Management and Therapeutic Strategies for the Thyroid-Associated Ophthalmopathy: Current and Future Perspectives., PMID:32567373
Role of IRF5 in the pathogenesis of immunoglobulin-A vasculitis., PMID:32441646
TRIM21 Dysfunction Enhances Aberrant B-Cell Differentiation in Autoimmune Pathogenesis., PMID:32117252
IRF5 genetic risk variants drive myeloid-specific IRF5 hyperactivation and presymptomatic SLE., PMID:31877114
PtpA and PknG Proteins Secreted by Mycobacterium avium subsp. paratuberculosis are Recognized by Sera from Patients with Rheumatoid Arthritis: A Case-Control Study., PMID:31819587
Modifications of the Transcriptomic Profile of Autoreactive B Cells From Pemphigus Patients After Treatment With Rituximab or a Standard Corticosteroid Regimen., PMID:31440235
A comprehensive review of rituximab therapy in rheumatoid arthritis patients., PMID:31367943
Antiphospholipid syndrome's genetic and epigenetic aspects., PMID:31323355
Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients., PMID:31156624
Irf5 deficiency in myeloid cells prevents necrotizing enterocolitis by inhibiting M1 macrophage polarization., PMID:31086271
Genetic implications in the pathogenesis of rheumatoid arthritis; an updated review., PMID:30904715
The Post-GWAS Era: How to Validate the Contribution of Gene Variants in Lupus., PMID:30673885
For research use only. Not for human or drug use.
