Please ensure Javascript is enabled for purposes of website accessibility
Home / Products / Antibody / Recombinant Antibody

Anti-PLCG2 Antibody (R3E65)

Catalog #:   RHD19503 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG1
Applications: ELISA, IHC
Accession: P16885
Overview

Catalog No.

RHD19503

Species reactivity

Human

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

ELISA: 1:10000, IHC: 1:200-1:1000

Target

PLC-gamma-2, Phosphoinositide phospholipase C-gamma-2, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, PLC-IV, Phospholipase C-gamma-2, PLCG2, Phospholipase C-IV

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P16885

Applications

ELISA, IHC

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3E65

Data Image
  • Immunohistochemical
    Immunohistochemical analysis of paraffin-embedded human Hela tissues using PLCG2 mouse mAb with DAB staining.
References

Case Report: de novo in-frame deletion in PLCG2 gene: a case report of B-cell lymphopenia, pulmonary bullae, and cutis laxa., PMID:40170866

Monoallelic expression can govern penetrance of inborn errors of immunity., PMID:39743591

Splice site and de novo variants can cause PLCG2-associated immune dysregulation with cold urticaria., PMID:39667583

A guide to selecting high-performing antibodies for PLC-gamma-2 for use in Western Blot, immunoprecipitation and immunofluorescence., PMID:39429638

Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing., PMID:39381601

Genetic regulation of B cell receptor signaling pathway: Insights from expression quantitative trait locus analysis using a mixed model., PMID:39236423

PLCG2 variants in cherubism., PMID:39197752

Characterization of a Novel Pathogenic PLCG2 Variant Leading to APLAID Syndrome Responsive to a TNF Inhibitor., PMID:38965708

Splice site and de novo mutations can cause mixed dominant negative/gain of function PLCG2-associated immune dysregulation with cold urticaria (CU-PLAID)., PMID:38562814

Five-year follow-up of a phase 2 study of ibrutinib plus fludarabine, cyclophosphamide, and rituximab as initial therapy in CLL., PMID:38163317

PLCG2-associated immune dysregulation (PLAID) comprises broad and distinct clinical presentations related to functional classes of genetic variants., PMID:37769878

Human PLCG2 haploinsufficiency results in a novel natural killer cell immunodeficiency., PMID:37714437

B-cell Receptor Pathway Mutations Are Infrequent in Patients with Chronic Lymphocytic Leukemia on Continuous Ibrutinib Therapy., PMID:37314786

G-CSF drives autoinflammation in APLAID., PMID:36997670

A rare case of PLCG2-associated antibody deficiency and immune dysregulation associated with a synonymous variant in the PLCG2 gene., PMID:36799558

Variant in the PLCG2 Gene May Cause a Phenotypic Overlap of APLAID/PLAID: Case Series and Literature Review., PMID:35955991

Mechanisms of Resistance to Noncovalent Bruton's Tyrosine Kinase Inhibitors., PMID:35196427

A novel likely pathogenic PLCG2 variant in a patient with a recurrent skin blistering disease and B-cell lymphopenia., PMID:34768012

Phospholipase Cγ2 Is Essential for Experimental Models of Epidermolysis Bullosa Acquisita., PMID:34656615

PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages., PMID:34615897

Circulating tumor DNA for comprehensive noninvasive monitoring of lymphoma treated with ibrutinib plus nivolumab., PMID:34500472

The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration., PMID:34157287

There is no gene for CVID - novel monogenetic causes for primary antibody deficiency., PMID:34153571

Case Report: A Rare Case of Autoinflammatory Phospholipase Cγ2 (PLCγ2)-Associated Antibody Deficiency and Immune Dysregulation Complicated With Gangrenous Pyoderma and Literature Review., PMID:34093563

Connection of BANK1, Tolerance, Regulatory B cells, and Apoptosis: Perspectives of a Reductionist Investigation., PMID:33815360

Neutrophil Phospholipase Cγ2 Drives Autoantibody-Induced Arthritis Through the Generation of the Inflammatory Microenvironment., PMID:33645887

Severe epidermolysis bullosa/Kindler syndrome-like phenotype of an autoinflammatory syndrome in a child., PMID:33625737

Novel genetic variants in genes of the Fc gamma receptor-mediated phagocytosis pathway predict non-small cell lung cancer survival., PMID:32676321

Severe Autoinflammatory Manifestations and Antibody Deficiency Due to Novel Hypermorphic PLCG2 Mutations., PMID:32671674

BCALM (AC099524.1) Is a Human B Lymphocyte-Specific Long Noncoding RNA That Modulates B Cell Receptor-Mediated Calcium Signaling., PMID:32571842

Phosphoflow Protocol for Signaling Studies in Human and Murine B Cell Subpopulations., PMID:32253241

Spectrum of Genetic Autoinflammatory Diseases Presenting with Cutaneous Symptoms., PMID:32147748

A new report of autoinflammation and PLCG2-associated antibody deficiency and immune dysregulation (APLAID) with a homozygous pattern from Iran., PMID:32014489

A Germline Mutation in the C2 Domain of PLCγ2 Associated with Gain-of-Function Expands the Phenotype for PLCG2-Related Diseases., PMID:31853824

PLAID syndrome: Characteristic presentation and a novel therapeutic option., PMID:31633221

Expanding the clinical features of autoinflammation and phospholipase Cγ2-associated antibody deficiency and immune dysregulation by description of a novel patient., PMID:31465591

Novel PLCG2 Mutation in a Patient With APLAID and Cutis Laxa., PMID:30619256

Functional characterization of phospholipase C-γ2 mutant protein causing both somatic ibrutinib resistance and a germline monogenic autoinflammatory disorder., PMID:30344948

Simulation of the Dynamics of Primary Immunodeficiencies in B Cells., PMID:30116248

Tespa1 Deficiency Dampens Thymus-Dependent B-Cell Activation and Attenuates Collagen-Induced Arthritis in Mice., PMID:29867947

A CD19/CD3 bispecific antibody for effective immunotherapy of chronic lymphocytic leukemia in the ibrutinib era., PMID:29743179

A comparative global phosphoproteomics analysis of obinutuzumab (GA101) versus rituximab (RTX) against RTX sensitive and resistant Burkitt lymphoma (BL) demonstrates differential phosphorylation of signaling pathway proteins after treatment., PMID:29371955

The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy., PMID:29259203

A systems medicine approach for finding target proteins affecting treatment outcomes in patients with non-Hodgkin lymphoma., PMID:28892521

BTKC481S-Mediated Resistance to Ibrutinib in Chronic Lymphocytic Leukemia., PMID:28418267

The Phospholipase Cγ2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein., PMID:27542411

Genes associated with common variable immunodeficiency: one diagnosis to rule them all?, PMID:27250108

A Gain-Of-Function Mutation in the Plcg2 Gene Protects Mice from Helicobacter felis-Induced Gastric MALT Lymphoma., PMID:26966907

Autoimmunity and Immune Dysregulation in Primary Immune Deficiency Disorders., PMID:26233425

PLAID: a Syndrome of Complex Patterns of Disease and Unique Phenotypes., PMID:26206677

Datasheet

Document Download

Anti-PLCG2 Antibody (R3E65).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

Contact Information

Order: order@antibodysystem.com

Mail: support@antibodysystem.com

Distributor list

For research use only. Not for human or drug use.

Need help with your order?

Find out more about placing an order here

Anti-PLCG2 Antibody (R3E65) [RHD19503]
Terms of sale Website terms of use Cookie policy Privacy
Copyright © 2025 AntibodySystem SAS. All Rights Reserved.            All Products are for Research Use Only