Catalog No.
RHD34302
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
IHC: 1:50-1:200, WB: 1:500-1:1000
Target
SS-A, E3 ubiquitin-protein ligase TRIM21, TRIM21, Ro(SS-A), 52 kDa Ro protein, Tripartite motif-containing protein 21, RING finger protein 81, 52 kDa ribonucleoprotein autoantigen Ro/SS-A, RNF81, Sjoegren syndrome type A antigen, RO52, RING-type E3 ubiquitin transferase TRIM21, SSA1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P19474
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3F35
Crystallographic fragment screening reveals ligand hotspots in TRIM21 PRY-SPRY domain., PMID:40514378
Anti-Ro52 Seropositive Interstitial Lung Disease is Associated with a Higher Risk for Disease Progression and Mortality., PMID:40484372
Mechanistic considerations linking SARS-CoV-2 infection, inflammation, and the loss of immune tolerance., PMID:40412200
Dual roles of CXCR4 (C-X-C motif chemokine receptor 4) in promoting entry of ebolavirus and targeting excessive glycoprotein for reticulophagic degradation to facilitate viral fitness., PMID:40223186
Potential Novel Tissue Biomarkers in Salivary Glands of Patients with Sjogren's Syndrome., PMID:40217840
Pulmonary Myeloid Cells in Mild Cases of COVID-19 Upregulate the Intracellular Fc Receptor TRIM21 and Transcribe Proteasome-Associated Molecules., PMID:40141410
RBMS3-loss impedes TRIM21-induced ubiquitination of ANGPT2 in an RNA-independent manner and drives sorafenib resistance in hepatocellular carcinoma., PMID:40069332
The antibody repertoire of autoimmune sensory neuronopathies targets pathways of the innate and adaptive immune system. An autoantigenomic approach., PMID:40026393
Reply to the letter "New perspectives in the management of SARS-CoV-2 Pirola variants and the development of long COVID syndrome: anti-Ro52/TRIM21 antibodies and qRT-PCR"., PMID:39832327
New perspectives in the management of SARS-CoV-2 Pirola variants and the development of long COVID syndrome: anti-Ro52/TRIM21 antibodies and qRT-PC., PMID:39832320
Staudinger Reaction-Responsive Coacervates for Cytosolic Antibody Delivery and TRIM21-Mediated Protein Degradation., PMID:39805770
CKAP4 in hepatocellular carcinoma: competitive RETREG1/FAM134B binding, reticulophagy regulation, and cancer progression., PMID:39689859
Generation and Characterization of a TRIM21 Overexpressing Mouse Line., PMID:39487578
Evidence that autoantibody production may be driven by acute Epstein-Barr virus infection in Sjögren's disease., PMID:39472059
Antibodies targeting the Crimean-Congo Hemorrhagic Fever Virus nucleoprotein protect via TRIM21., PMID:39455551
Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function., PMID:39276772
Aggregate-selective removal of pathological tau by clustering-activated degraders., PMID:39208111
Roles of TRIM21/Ro52 in connective tissue disease-associated interstitial lung diseases., PMID:39165359
Zn0-Induced Cytotoxicity and Mitochondrial Stress in Microglia: Implications of the Protective Role of Immunoglobulin G In Vitro., PMID:39129512
Identification of Pathogenic Pathways for Recurrence of Focal Segmental Glomerulosclerosis after Kidney Transplantation., PMID:39125467
Nasal tau immunotherapy clears intracellular tau pathology and improves cognitive functions in aged tauopathy mice., PMID:38959324
Coexistence of systemic sclerosis and cryopyrin-associated periodic syndrome., PMID:38940218
TRIM21 and Fc-engineered antibodies: decoding its complex antibody binding mode with implications for viral neutralization., PMID:38938560
Remodeling of anti-tumor immunity with antibodies targeting a p53 mutant., PMID:38886748
Serum levels of anti-Ro52/TRIM21 antibodies in SARS-CoV-2 genetic variants and long COVID. Beyond their application in autoimmune diseases., PMID:38753568
Pin1-Catalyzed Conformation Changes Regulate Protein Ubiquitination and Degradation., PMID:38727267
Multifaceted role of TRIM21 in inflammation., PMID:38717710
Prevalence of anti-Ro52-kDa/SSA (TRIM21) antibodies and associated clinical phenotype in systemic sclerosis: Data from a French cohort, a systematic review and meta-analysis., PMID:38555075
Retrospective analysis of the clinical significance of Ro52/TRIM21 antibody and specific antinuclear antibody patterns by indirect immunofluorescence., PMID:38419219
Systems genetics of influenza A virus-infected mice identifies TRIM21 as a critical regulator of pulmonary innate immune response., PMID:38331257
Characterised intron retention profiles in muscle tissue of idiopathic inflammatory myopathy subtypes., PMID:38302260
Association of Combined Anti-Ro52/TRIM21 and Anti-Ro60/SSA Antibodies With Increased Sjögren Disease Severity Through Interferon Pathway Activation., PMID:38130019
The interconnected roles of TRIM21/Ro52 in systemic lupus erythematosus, primary Sjögren's syndrome, cancers, and cancer metabolism., PMID:37993883
Identification of Diagnosis and Typological Characteristics Associated with Ferroptosis for Ulcerative Colitis via Bioinformatics and Machine Learning., PMID:37957905
A Interacting Model: How TRIM21 Orchestrates with Proteins in Intracellular Immunity., PMID:37922533
A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation., PMID:37925433
Ro52/TRIM21 - From host defense to autoimmunity., PMID:37857191
TRIM55 promotes noncanonical NF-κB signaling and B cell-mediated immune responses by coordinating p100 ubiquitination and processing., PMID:37816088
Protective mechanisms of nonneutralizing antiviral antibodies., PMID:37796829
EGFR-Induced and c-Src-Mediated CD47 Phosphorylation Inhibits TRIM21-Dependent Polyubiquitylation and Degradation of CD47 to Promote Tumor Immune Evasion., PMID:37541303
LANCL1, a cell surface protein, promotes liver tumor initiation through FAM49B-Rac1 axis to suppress oxidative stress., PMID:37540188
The Toll-like Receptor 7-Mediated Ro52 Antigen-Presenting Pathway in the Salivary Gland Epithelial Cells of Sjögren's Syndrome., PMID:37445456
Validation of an indirect ELISA assay for assessment of autoantibodies against full-length TRIM21 and its individual domains., PMID:37379227
Plasma proteomic profiling reveals KRT19 could be a potential biomarker in patients with anti-MDA5+ dermatomyositis., PMID:37160775
Serological intermolecular epitope spreading in a patient with primary Sjögren's syndrome., PMID:37130648
Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates., PMID:37061529
Isolated anti-Ro52 identifies a severe subset of Sjögren's syndrome patients., PMID:37006271
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models., PMID:36996217
Anti-Ro52/TRIM21 antibodies are associated with aberrant inflammatory circuits in patients with systemic autoimmune rheumatic diseases., PMID:36930561
TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away., PMID:36807144