Anti-DLL1 Antibody (R2T54)

Catalog No.

RHA15301

Species reactivity

Human, Rat

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

IHC: 1:100-1:200, WB: 1:500-1:1000

Target

DLL1, Drosophila Delta homolog 1, Delta1, H-Delta-1, Delta-like protein 1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O00548

Applications

IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R2T54

Brain ischemia causes systemic Notch1 activity in endothelial cells to drive atherosclerosis., PMID:39079536

Another Notch in the Belt of Rheumatoid Arthritis., PMID:38961731

Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages., PMID:38636522

Group 3 Innate Lymphoid Cells Exacerbate Lupus Nephritis by Promoting B Cell Activation in Kidney Ectopic Lymphoid Structures., PMID:37915129

Notch ligands are biomarkers of anti-TNF response in RA patients., PMID:37796367

CSF-1 and Notch signaling cooperate in macrophage instruction and tissue repair during peripheral limb ischemia., PMID:37691936

Lentinan enhances the antitumor effects of Delta-like 1 via neutrophils., PMID:36008793

Notch Signaling Promotes Mature T-Cell Lymphomagenesis., PMID:36006995

Anti-Jagged-1 immunotherapy in cancer., PMID:35421813

Relationship of Notch Signal, Surfactant Protein A, and Indomethacin in Cervix During Preterm Birth: Mast Cell and Jagged-2 May Be Key in Understanding Infection-mediated Preterm Birth., PMID:34927491

Activity of the mouse Notch ligand DLL1 is sensitive to C-terminal tagging in vivo., PMID:34583743

Development of Dl1.72, a Novel Anti-DLL1 Antibody with Anti-Tumor Efficacy against Estrogen Receptor-Positive Breast Cancer., PMID:34439228

Delta-like 1-Expressing Cells at the Gland Base Promote Proliferation of Gastric Antral Stem Cells in Mouse., PMID:34438113

Development of antibodies against the notch ligand Delta-Like-1 by phage display with activity against breast cancer cells., PMID:33992842

Computationally-obtained structural insights into the molecular interactions between Pidilizumab and binding partners DLL1 and PD-1., PMID:33559526

The 3D Pattern of the Rainbow Trout (Oncorhynchus mykiss) Enterocytes and Intestinal Stem Cells., PMID:33276531

Reciprocal communication between astrocytes and endothelial cells is required for astrocytic glutamate transporter 1 (GLT-1) expression., PMID:32650029

CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells., PMID:32457739

Heterogeneity of Satellite Cells Implicates DELTA1/NOTCH2 Signaling in Self-Renewal., PMID:32023464

Precision medicine for human cancers with Notch signaling dysregulation (Review)., PMID:31894255

Retinal myeloid cells regulate tip cell selection and vascular branching morphogenesis via Notch ligand Delta-like 1., PMID:31278348

Notch Signaling Promotes Development of Allergic Rhinitis by Suppressing Foxp3 Expression and Treg Cell Differentiation., PMID:30391960

Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice., PMID:30181175

Production and characterization of a novel Delta-like 1 functional unit as a tool for Notch pathway activation and generation of a specific antibody., PMID:29366964

Notch Ligand Binding Assay Using Flow Cytometry., PMID:29333477

Identification of small molecules uncoupling the Notch::Jagged interaction through an integrated high-throughput screening., PMID:29099834

Overexpression of Notch ligand Delta-like-1 by dendritic cells enhances their immunoregulatory capacity and exerts antiallergic effects on Th2-mediated allergic asthma in mice., PMID:29038036

Both Notch1 and its ligands in B cells promote antibody production., PMID:28863329

Requirement of Gαq/Gα11 Signaling in the Preservation of Mouse Intestinal Epithelial Homeostasis., PMID:28174748

Notch signalling suppresses regulatory T-cell function in murine experimental autoimmune uveitis., PMID:27564686

Decidual vascular endothelial cells promote maternal-fetal immune tolerance by inducing regulatory T cells through canonical Notch1 signaling., PMID:26714886

TGFBIp regulates differentiation of EPC (CD133(+) C-kit(+) Lin(-) cells) to EC through activation of the Notch signaling pathway., PMID:25786978

Transient blockade of delta-like Notch ligands prevents allograft rejection mediated by cellular and humoral mechanisms in a mouse model of heart transplantation., PMID:25687759

Notching on Cancer's Door: Notch Signaling in Brain Tumors., PMID:25601901

Notch2 controls prolactin and insulin-like growth factor binding protein-1 expression in decidualizing human stromal cells of early pregnancy., PMID:25397403

NOTCH decoys that selectively block DLL/NOTCH or JAG/NOTCH disrupt angiogenesis by unique mechanisms to inhibit tumor growth., PMID:25387766

Macrophage-derived delta-like protein 1 enhances interleukin-6 and matrix metalloproteinase 3 production by fibroblast-like synoviocytes in mice with collagen-induced arthritis., PMID:24943093

GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development., PMID:24929016

Identification of a human splenic marginal zone B cell precursor with NOTCH2-dependent differentiation properties., PMID:24733829

Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells., PMID:24562309

Notch ligand delta-like 4-pretreated dendritic cells alleviate allergic airway responses by enhancing IL-10 production., PMID:23696838

MicroRNA-34a is a tumor suppressor in choriocarcinoma via regulation of Delta-like1., PMID:23327670

Regeneration of human tumor antigen-specific T cells from iPSCs derived from mature CD8(+) T cells., PMID:23290135

Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes., PMID:22390640

Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice., PMID:22333952

Regulation of experimental autoimmune uveoretinitis by anti-delta-like ligand 4 monoclonal antibody., PMID:21896864

Expression of Notch receptors, ligands, and target genes during development of the mouse mammary gland., PMID:21506125

Two Notch ligands, Dll1 and Jag1, are differently restricted in their range of action to control neurogenesis in the mammalian spinal cord., PMID:21124801

Notch1 induces enhanced expression of Delta-like-1 in the U251MG glioma cell line., PMID:19724883

Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1., PMID:19598246

Document Download

Anti-DLL1 Antibody (R2T54).pdf