Catalog No.
AHJ36502
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Thr22-Pro231
Predicted molecular weight
51.8 kDa
Nature
Recombinant
Endotoxin level
< 1 EU/µg as determined by LAL test.
Purity
>90% as determined by SDS-PAGE.
Accession
Q969J5-2
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a 0.2 μm filtered solution in 20 mM PB, 150 mM NaCl, pH 7.4.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Interleukin-22 Receptor Subunit Alpha-2, IL-22 Receptor Subunit Alpha-2, IL-22R-Alpha-2, IL-22RA2, Cytokine Receptor Class-II Member 10, Cytokine Receptor Family 2 Member 10, CRF2-10, Cytokine Receptor Family Type 2 Soluble 1, CRF2-S1, Interleukin-22-Binding Protein, IL-22BP, IL22BP, ZcytoR16, IL22RA2
Epstein-Barr Virus BRRF1 Induces Butyrophilin 2A1 in Nasopharyngeal Carcinoma NPC43 Cells via the IL-22/JAK3-STAT3 Pathway., PMID:39769218
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens., PMID:38687788
Identification of a novel glioblastoma multiforme molecular subtype with poor prognosis and high immune infiltration based on oxidative stress-related genes., PMID:38363895
Th22 is the effector cell of thymosin β15-induced hair regeneration in mice., PMID:38191481
IL-22 Binding Protein Controls IL-22-Driven Bleomycin-Induced Lung Injury., PMID:38101567
Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension., PMID:37975916
Integrating GWAS and proteome data to identify novel drug targets for MU., PMID:37369724
IL-22RA2 Is a SMAD7 Target Mediating the Alleviation of Dermatitis and Psoriatic Phenotypes in Mice., PMID:37211203
Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression., PMID:36932082
Wheat Germ Supplementation Reduces Inflammation and Gut Epithelial Barrier Dysfunction in Female Interleukin-10 Knockout Mice Fed a Pro-Atherogenic Diet., PMID:36813578
IL-22BP production is heterogeneously distributed in Crohn's disease., PMID:36311796
Down-regulating Interleukin-22/Interleukin-22 binding protein axis promotes inflammation and aggravates diet-induced metabolic disorders., PMID:36108991
IL22RA1/JAK/STAT Signaling Acts As a Cancer Target Through Pan-Cancer Analysis., PMID:35874683
MicroRNA-155-5p modulates the progression of acute respiratory distress syndrome by targeting interleukin receptors., PMID:35506298
TNF hampers intestinal tissue repair in colitis by restricting IL-22 bioavailability., PMID:35383266
IL-22 Plays a Dual Role in the Amniotic Cavity: Tissue Injury and Host Defense against Microbes in Preterm Labor., PMID:35304419
Newborn DNA methylation and asthma acquisition across adolescence and early adulthood., PMID:34995380
IL-22 Binding Protein (IL-22BP) in the Regulation of IL-22 Biology., PMID:34868019
Influence of Genetic Polymorphisms on Clinical Outcomes of Glatiramer Acetate in Multiple Sclerosis Patients., PMID:34683173
Prurigo Nodularis Is Characterized by Systemic and Cutaneous T Helper 22 Immune Polarization., PMID:33771530
A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration., PMID:33042126
Low Interleukin-22 Binding Protein Is Associated With High Mortality in Alcoholic Hepatitis and Modulates Interleukin-22 Receptor Expression., PMID:32955203
Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax., PMID:32632545
IL22BP Mediates the Antitumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans., PMID:32585307
Effect of apigenin on whole transcriptome profile of TNFα-activated MDA-MB-468 triple negative breast cancer cells., PMID:32194710
The Rare IL22RA2 Signal Peptide Coding Variant rs28385692 Decreases Secretion of IL-22BP Isoform-1, -2 and -3 and Is Associated with Risk for Multiple Sclerosis., PMID:31936765
Targeting the IL-22/IL-22BP axis enhances tight junctions and reduces inflammation during influenza infection., PMID:31597930
Interleukin-22 (IL-22) Binding Protein Constrains IL-22 Activity, Host Defense, and Oxidative Phosphorylation Genes during Pneumococcal Pneumonia., PMID:31451621
IL-18/IL-18BP and IL-22/IL-22BP: Two interrelated couples with therapeutic potential., PMID:31401146
IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis., PMID:31292217
Expression Profiling of Inflammatory and Immunological Genes in Collagenous Colitis., PMID:31131860
Pharmacological Targeting of the ER-Resident Chaperones GRP94 or Cyclophilin B Induces Secretion of IL-22 Binding Protein Isoform-1 (IL-22BPi1)., PMID:31108847
Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response., PMID:30619294
Ras homolog gene family H (RhoH) deficiency induces psoriasis-like chronic dermatitis by promoting TH17 cell polarization., PMID:30339851
IL-22 Down-Regulates Cx43 Expression and Decreases Gap Junctional Intercellular Communication by Activating the JNK Pathway in Psoriasis., PMID:30171832
Molecular characterization and expression analysis of IL-22 and its two receptors genes in yellow catfish (Pelteobagrus filvidraco) in response to Edwardsiella ictaluri challenge., PMID:29886141
Regulation of IL-22BP in psoriasis., PMID:29572462
A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury., PMID:29109123
Gene expression profiling of the Notch-AhR-IL22 axis at homeostasis and in response to tissue injury., PMID:29054964
IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake., PMID:28512157
Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation., PMID:28356382
A Functional IL22 Polymorphism (rs2227473) Is Associated with Predisposition to Childhood Cerebral Malaria., PMID:28139719
How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?, PMID:28050571
Human IL-22 binding protein isoforms act as a rheostat for IL-22 signaling., PMID:27678220
IL-22 binding protein regulates murine skin inflammation., PMID:27676439
Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children., PMID:27530235
Functional and molecular factors associated with TAPSE in hypoxic pulmonary hypertension., PMID:27106290
Deletion of the entire interferon-γ receptor 1 gene causing complete deficiency in three related patients., PMID:26931784
Pathogen Resistance Mediated by IL-22 Signaling at the Epithelial-Microbiota Interface., PMID:26497621
Esophageal Cancer Epigenomics and Integrome Analysis of Genome-Wide Methylation and Expression in High Risk Northeast Indian Population., PMID:26496483
For research use only. Not for human or drug use.
