Catalog No.
EHD00601
Description
Tissue factor, also called platelet tissue factor, factor III, or CD142, is a protein encoded by the F3 gene, present in subendothelial tissue and leukocytes. CD142, also known as ,Coagulation Factor III, and Thromboplastin, is a 45 kD type I transmembrane glycoprotein. CD142 is a high-affinity receptor for coagulation factor VII and initiates the extrinsic pathway of blood coagulation. CD142 also plays an important role in a variety of diseases such as sepsis, atherosclerosis, and cancer. It is expressed on the surface of a variety of cells that are physically separated from the circulating blood which include smooth muscle cells, fibroblasts, keratinocytes, glomerular epithelial cells (cytoplasmic inclusions), astrocytes, myocardium, liver stromal cells, pancreas cells, and is also expressed on activated monocytes and stimulated endothelial cells.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Glu251
Predicted molecular weight
29.24 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P13726
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Tissue factor, CD142, F3, Thromboplastin, Coagulation factor III, TF
CD142 plays an important role in the mobility of colorectal cancer cells. PMID: 32471327
Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease. PMID: 30270042
Identification of a mesenchymal progenitor cell hierarchy in adipose tissue. PMID: 31023895
CD142 plays a key role in the carcinogenesis of gastric adenocarcinoma by inhibiting BCL2-dependent autophagy. PMID: 34289309
A stromal cell population that inhibits adipogenesis in mammalian fat depots. PMID: 29925944
CD142+/CD61+, CD146+ and CD45+ microparticles predict cardiovascular events in high risk patients following a Mediterranean diet supplemented with nuts. PMID: 27052787
Single-cell RNA-seq highlights heterogeneity in human primary Wharton's jelly mesenchymal stem/stromal cells cultured in vitro. PMID: 32252818
MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy. PMID: 32574263
Intravascular Mesenchymal Stromal/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines. PMID: 30711482
High levels of TSP1+/CD142+ platelet-derived microparticles characterise young patients with high cardiovascular risk and subclinical atherosclerosis. PMID: 26178021
Putative Natural History of CoViD-19. PMID: 32831521
Monocyte-derived circulating microparticles (CD14(+), CD14(+)/CD11b(+) and CD14(+)/CD142(+)) are related to long-term prognosis for cardiovascular mortality in STEMI patients. PMID: 27915085
64Cu-1,4,7-Triazacyclononane-1,4,7-triacetic acid-p-isothiocyanatobenzyl-ALT-836. PMID: 23534079
Increase in expression of monocytic tissue factor (CD142) with monocytes and blood platelet activation in liver cirrhosis. PMID: 17982314
Interstitial Cell Remodeling Promotes Aberrant Adipogenesis in Dystrophic Muscles. PMID: 32375047
Frail older adults show a distinct plasma microvesicle profile suggesting a prothrombotic and proinflammatory phenotype. PMID: 32749745
Tissue factor in the antiphospholipid syndrome. PMID: 18827061
Current Targets and Bioconjugation Strategies in Photodynamic Diagnosis and Therapy of Cancer. PMID: 33121022
Circulating extracellular vesicles are endowed with enhanced procoagulant activity in SARS-CoV-2 infection. PMID: 33971404
[Level of Microparticles in Patients with Essential Thrombocythemia and Its Relation with JAK2V617F Mutation]. PMID: 33283740
Predictive Markers for Malignant Urothelial Transformation in Balkan Endemic Nephropathy: A Case-Control Study. PMID: 33065960
Platelet-, monocyte-derived and tissue factor-carrying circulating microparticles are related to acute myocardial infarction severity. PMID: 28207887
Effects of acute insulin-induced hypoglycaemia on endothelial microparticles in adults with and without type 2 diabetes. PMID: 30264480
Adult human pancreatic acinar cells dedifferentiate into an embryonic progenitor-like state in 3D suspension culture. PMID: 30858455
Platelet-derived microparticles during and after acute coronary syndrome. PMID: 22371053
Monocyte tissue factor (CD142) and Mac-1 (CD11b) are increased in septic patients. PMID: 9657455
Tissue factor: a key molecule in hemostatic and nonhemostatic systems. PMID: 15005335
Critical COVID-19 is associated with distinct leukocyte phenotypes and transcriptome patterns. PMID: 34080738
The Mediterranean diet decreases prothrombotic microvesicle release in asymptomatic individuals at high cardiovascular risk. PMID: 32147198
Annexin V+ Microvesicles in Children and Adolescents with Type 1 Diabetes: A Prospective Cohort Study. PMID: 32309448
Possibility of Coagulation System Activation Determination with Tissue Factor in Pregnancy Complications. PMID: 28164533
The biology and tumour-related properties of monocyte tissue factor. PMID: 11169509
17β-Estradiol Promotes Proinflammatory and Procoagulatory Phenotype of Innate Immune Cells in the Presence of Antiphospholipid Antibodies. PMID: 32549383
Non-neoplastic Portal Vein Thrombosis in HCV Cirrhosis Patients: Is it an Immuno-Inflammatory Disorder? PMID: 28611261
A multicolor flow cytometric assay for measurement of platelet-derived microparticles. PMID: 19939440
Circulating endothelial cells in patients with venous thromboembolism and myeloproliferative neoplasms. PMID: 24339944
Increased Expression of Extracellular Vesicles Is Associated With the Procoagulant State in Patients With Established Rheumatoid Arthritis. PMID: 34394126
Seminal clotting and fibrinolytic balance: a possible physiological role in the male reproductive system. PMID: 15467906
Elevated circulating levels of tissue factor-positive microvesicles are associated with distant metastasis in lung cancer. PMID: 24169761
Plasma levels of extracellular vesicles and the risk of post-operative pulmonary embolism in patients with primary brain tumors: a prospective study. PMID: 33837918
Procoagulant activity of human mesenchymal stem cells. PMID: 28628602
Flow cytometric characterization of the saphenous veins endothelial cells in patients with chronic venous disease and in patients undergoing bypass surgery: an exploratory study. PMID: 31227876
PAR-4/Ca2+-calpain pathway activation stimulates platelet-derived microparticles in hyperglycemic type 2 diabetes. PMID: 33812377
Anti-domain 1 β2 glycoprotein antibodies increase expression of tissue factor on monocytes and activate NK Cells and CD8+ cells in vitro. PMID: 32127041
Activated platelets and leukocyte activations in young patients with β-thalassemia/HbE following bone marrow transplantation. PMID: 29990620
Reconstructing human pancreatic differentiation by mapping specific cell populations during development. PMID: 28731406
Mesenchymal stem cell transfusion: Possible beneficial effects in COVID-19 patients. PMID: 34419356
Association of microparticles and neutrophil activation with decompression sickness. PMID: 26139218
Mesenchymal stromal cell therapy for coronavirus disease 2019: which? when? and how much? PMID: 34053857
Endothelial Microparticles and Blood Coagulation Activation in Head and Neck Cancer Patients Undergoing Radiotherapy or Radiochemotherapy. PMID: 30804151
Adverse effects of fullerenes on endothelial cells: fullerenol C60(OH)24 induced tissue factor and ICAM-I membrane expression and apoptosis in vitro. PMID: 18488416
Studies of microparticles in patients with the antiphospholipid syndrome (APS). PMID: 22635239
Elevated coagulation factor levels affect the tissue factor-threshold in thrombin generation. PMID: 30408635
Temporal dynamics of microparticle elevation following subarachnoid hemorrhage. PMID: 22794324
HIV and cardiovascular diseases risk: exploring the interplay between T-cell activation, coagulation, monocyte subsets, and lipid subclass alterations. PMID: 30768357
Soluble endothelial cell molecules and circulating endothelial cells in patients with venous thromboembolism. PMID: 28661913
Signal Transduction Peptide of Tissue Factor Phosphorylated at Ser258 and the Unphosphorylated STP in Urine Are Potential Biomarkers for Bladder Cancer. PMID: 30579699
Markers of endothelial damage in patients with chronic kidney disease on hemodialysis. PMID: 28077371
Circulating levels and characterization of microparticles in patients with different degrees of glucose tolerance. PMID: 28927403
Profiling of the three circulating monocyte subpopulations in human obesity. PMID: 25786686
Selection of Tissue Factor-Deficient Cell Transplants as a Novel Strategy for Improving Hemocompatibility of Human Bone Marrow Stromal Cells. PMID: 29507631
Enumeration and phenotyping of circulating microvesicles by flow cytometry and nanoparticle tracking analysis: Plasma versus serum. PMID: 33244869
Platelet, monocyte and neutrophil activation and glucose tolerance in South African Mixed Ancestry individuals. PMID: 28091589
Ascorbic acid abrogates microparticle generation and vascular injuries associated with high-pressure exposure. PMID: 25977448
Tissue Source and Cell Expansion Condition Influence Phenotypic Changes of Adipose-Derived Stem Cells. PMID: 29138638
Metformin reduces total microparticles and microparticles-expressing tissue factor in women with polycystic ovary syndrome. PMID: 28795250
Phenotypic mapping of human mesothelial cells. PMID: 10649685
Tumor-associated macrophages promote invasion while retaining Fc-dependent anti-tumor function. PMID: 23105143
Elevated levels of circulating microvesicles in coronary artery disease patients with type 2 diabetes and albuminuria: Effects of exercise training. PMID: 31023084
PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression. PMID: 25293769
Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells. PMID: 21804561
Platelet leukocyte aggregates and markers of platelet aggregation, immune activation and disease progression in HIV infected treatment naive asymptomatic individuals. PMID: 25899563
Cancer Cell-Derived Extracellular Vesicles Are Associated with Coagulopathy Causing Ischemic Stroke via Tissue Factor-Independent Way: The OASIS-CANCER Study. PMID: 27427978
Ascorbic acid supplementation diminishes microparticle elevations and neutrophil activation following SCUBA diving. PMID: 26084697
Atraumatic Pulsatile Leukocyte Circulation for Long-Term In Vitro Dynamic Culture and Adhesion Assays. PMID: 25894522
Flow cytometric analysis of microparticle phenotype and their role in thrombin generation. PMID: 20632415
Extracellular Vesicle Surface Markers as a Diagnostic Tool in Transient Ischemic Attacks. PMID: 34344167
Evaluation of Alpha-Thalassemia Mutations in Cases with Hypochromic Microcytic Anemia: The İstanbul Perspective. PMID: 26377141
MEIS1 and MEIS2 Expression and Prostate Cancer Progression: A Role For HOXB13 Binding Partners in Metastatic Disease. PMID: 29716922
Endothelial cell activation and neovascularization are prominent in dermatomyositis. PMID: 16504012
Elevated procoagulant endothelial and tissue factor expressing microparticles in women with recurrent pregnancy loss. PMID: 24278436
Circulating microparticles, protein C, free protein S and endothelial vascular markers in children with sickle cell anaemia. PMID: 26609806
Levels of activated platelet-derived microvesicles in patients with soft tissue sarcoma correlate with an increased risk of venous thromboembolism. PMID: 28784104
A subpopulation of human B lymphocytes can express a functional Tissue Factor in response to phorbol myristate acetate. PMID: 16113798
Expansion of GARP-Expressing CD4+CD25-FoxP3+ T Cells and SATB1 Association with Activation and Coagulation in Immune Compromised HIV-1-Infected Individuals in South Africa. PMID: 33974229
Hb A2 Episkopi - a novel δ-globin chain variant [HBD:c.428C>T] in a family of mixed Cypriot-Lebanese descent. PMID: 28007020
Correlative analysis of nanoparticle tracking, flow cytometric and functional measurements for circulating microvesicles in normal subjects. PMID: 27429418
Activated Platelet-Derived and Leukocyte-Derived Circulating Microparticles and the Risk of Thrombosis in Heparin-Induced Thrombocytopenia: A Role for PF4-Bearing Microparticles? PMID: 28052584
First report of the spectrum of δ-globin gene mutations in Omani subjects - identification of novel mutations. PMID: 25043855
A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo. PMID: 25517311
Number of microparticles generated during acute myocardial infarction and stable angina correlates with platelet activation. PMID: 22306248
Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. PMID: 16402404
Oral glucocorticoid treatment decreases interleukin-10 receptor expression on peripheral blood leucocyte subsets. PMID: 19292765
The impact of various preanalytical treatments on the phenotype of small extracellular vesicles in blood analyzed by protein microarray. PMID: 27568281
Diabetes worsening of hepatitis C cirrhosis: are alterations in monocytic tissue factor (CD 142) is the cause? PMID: 24378263
Intracoronary platelet and monocyte activation status within platelet-monocyte complexes are determinants of inflammation in ST elevation myocardial infarction1. PMID: 26890234
Adenosine inhibition of adenosine diphosphate and thrombin-induced monocyte-platelet aggregates in cardiac syndrome X. PMID: 19185336
A Simple, Rapid, and Highly Sensitive Electrochemical DNA Sensor for the Detection of α- and β-Thalassemia in China. PMID: 27228385
Separating the roles of nitrogen and oxygen in high pressure-induced blood-borne microparticle elevations, neutrophil activation, and vascular injury in mice. PMID: 26048974
Distribution of alpha thalassaemia gene variants in diverse ethnic populations in malaysia: data from the institute for medical research. PMID: 24025420
Circulating microparticle signature in coronary and peripheral blood of ST elevation myocardial infarction patients in relation to pain-to-PCI elapsed time. PMID: 26432487
Atorvastatin reduces thrombin generation and expression of tissue factor, P-selectin and GPIIIa on platelet-derived microparticles in patients with peripheral arterial occlusive disease. PMID: 21614411
Immunophenotypic characterisation of carotid plaque: increased amount of inflammatory cells as an independent predictor for ischaemic symptoms. PMID: 11397022
Immunologic phenotype of cultured endothelial cells: quantitative analysis of cell surface molecules. PMID: 9389318
The detection of ADAM8 protein on cells of the human immune system and the demonstration of its expression on peripheral blood B cells, dendritic cells and monocyte subsets. PMID: 17270707
Difference in the blood monocyte phenotype between uremic patients and healthy controls: its relation to monocyte differentiation into macrophages in the peritoneal cavity. PMID: 9484650
Platelet-derived microparticles and coagulation activation in breast cancer patients. PMID: 18841290
Detection of tissue factor-positive microparticles and its clinical significance in the haemostatic disorder. PMID: 22931659
For research use only. Not for human or drug use.
